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eF-site ID
|
6p8h-ABC |
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PDB Code
|
6p8h |
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Chain
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A, B, C |
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click to enlarge
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Title
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Crystal structure of CDK4 in complex with CyclinD1 and P21 |
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Classification
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cell cycle, transferase |
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Compound
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G1/S-specific cyclin-D1 |
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Source
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(CDN1A_HUMAN) |
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Sequence
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A: |
DANLLNDRVLRAMLKAEETCAPSVSYFKCVQKEVLPSMRK
IVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKKSR
LQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELL
QMELLLVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQII
RKHAQTFVALCATDVKFISNPPSMVAAGSVVAAVQGLNLR
SPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEALLESS
LRQA
|
| B: |
GTVYKARDPGHFVALKSVRVPNGEEGLPISTVREVALLRR
LEAFEHPNVVRLMDVCATSREIKVTLVFEHVDQDLRTYLD
KAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPEN
ILVTSGGTVKLADFGLTLWYRAPEVLLQSTYATPVDMWSV
GCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPR
DVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNP
HKRISAFRALQHSYLHKD
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| C: |
GSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDF
VTETPLEGDFAWER
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Description
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Functional site
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|
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1)
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chain |
B |
| residue |
35 |
| type |
MOD_RES |
| sequence |
K
|
| description |
Phosphothreonine; by LKB1 => ECO:0000269|PubMed:25329316
|
| source |
Swiss-Prot : SWS_FT_FI2
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|
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2)
|
chain |
A |
| residue |
57-88 |
| type |
prosite |
| sequence |
RKIVATWMLEVCEEQKCEEEVFPLAMNYLDRF
|
| description |
CYCLINS Cyclins signature. RkiVatWMlevceeqkCeeevFplAMnYLDRF
|
| source |
prosite : PS00292
|
|
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3)
|
chain |
B |
| residue |
133-145 |
| type |
prosite |
| sequence |
IVHRDLKPENILV
|
| description |
PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHrDLKpeNILV
|
| source |
prosite : PS00108
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