eF-site ID 6p7i-D PDB Code 6p7i Chain D click to enlarge Title Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound Classification Transferase/Transferase Inhibitor Compound Protein arginine N-methyltransferase 6 Source (ANM6_HUMAN) Sequence D:  RPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGI LRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEAS AIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVS EWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIV PISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHS EIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGR FRCSCYGSAPMHGFAIWFQVTFPGEKPLVLSTSPFHPATH WKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLL RYKVGDQEEKTKDFAME Description Functional site 1) chain D residue 48 type sequence Y description binding site for residue SAH D 401 source : AC9 2) chain D residue 51 type sequence Y description binding site for residue SAH D 401 source : AC9 3) chain D residue 60 type sequence M description binding site for residue SAH D 401 source : AC9 4) chain D residue 66 type sequence R description binding site for residue SAH D 401 source : AC9 5) chain D residue 90 type sequence G description binding site for residue SAH D 401 source : AC9 6) chain D residue 91 type sequence A description binding site for residue SAH D 401 source : AC9 7) chain D residue 95 type sequence I description binding site for residue SAH D 401 source : AC9 8) chain D residue 96 type sequence L description binding site for residue SAH D 401 source : AC9 9) chain D residue 112 type sequence E description binding site for residue SAH D 401 source : AC9 10) chain D residue 113 type sequence A description binding site for residue SAH D 401 source : AC9 11) chain D residue 114 type sequence S description binding site for residue SAH D 401 source : AC9 12) chain D residue 138 type sequence G description binding site for residue SAH D 401 source : AC9 13) chain D residue 139 type sequence P description binding site for residue SAH D 401 source : AC9 14) chain D residue 140 type sequence V description binding site for residue SAH D 401 source : AC9 15) chain D residue 141 type sequence E description binding site for residue SAH D 401 source : AC9 16) chain D residue 155 type sequence E description binding site for residue SAH D 401 source : AC9 17) chain D residue 166 type sequence M description binding site for residue SAH D 401 source : AC9 18) chain D residue 169 type sequence S description binding site for residue SAH D 401 source : AC9 19) chain D residue 46 type sequence L description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 20) chain D residue 47 type sequence Y description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 21) chain D residue 48 type sequence Y description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 22) chain D residue 49 type sequence E description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 23) chain D residue 51 type sequence Y description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 24) chain D residue 52 type sequence S description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 25) chain D residue 53 type sequence D description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 26) chain D residue 59 type sequence E description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 27) chain D residue 155 type sequence E description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 28) chain D residue 157 type sequence M description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 29) chain D residue 159 type sequence Y description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 30) chain D residue 164 type sequence E description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 31) chain D residue 317 type sequence H description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 32) chain D residue 155 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 33) chain D residue 164 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 34) chain D residue 57 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 35) chain D residue 66 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 36) chain D residue 90 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 37) chain D residue 112 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 38) chain D residue 141 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 39) chain D residue 35 type MOD_RES sequence R description Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:23866860 source Swiss-Prot : SWS_FT_FI5 40) chain D residue 37 type MOD_RES sequence R description Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:23866860 source Swiss-Prot : SWS_FT_FI5

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