eF-site ID 6p7i-C PDB Code 6p7i Chain C click to enlarge Title Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound Classification Transferase/Transferase Inhibitor Compound Protein arginine N-methyltransferase 6 Source (ANM6_HUMAN) Sequence C:  RRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILR NWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAI WQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEW MGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPI SDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEI VVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFR CSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHW KQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLR YKVGDQEEKTKDFAMED Description Functional site 1) chain C residue 48 type sequence Y description binding site for residue SAH C 401 source : AC7 2) chain C residue 51 type sequence Y description binding site for residue SAH C 401 source : AC7 3) chain C residue 60 type sequence M description binding site for residue SAH C 401 source : AC7 4) chain C residue 66 type sequence R description binding site for residue SAH C 401 source : AC7 5) chain C residue 90 type sequence G description binding site for residue SAH C 401 source : AC7 6) chain C residue 91 type sequence A description binding site for residue SAH C 401 source : AC7 7) chain C residue 95 type sequence I description binding site for residue SAH C 401 source : AC7 8) chain C residue 96 type sequence L description binding site for residue SAH C 401 source : AC7 9) chain C residue 112 type sequence E description binding site for residue SAH C 401 source : AC7 10) chain C residue 113 type sequence A description binding site for residue SAH C 401 source : AC7 11) chain C residue 114 type sequence S description binding site for residue SAH C 401 source : AC7 12) chain C residue 139 type sequence P description binding site for residue SAH C 401 source : AC7 13) chain C residue 140 type sequence V description binding site for residue SAH C 401 source : AC7 14) chain C residue 141 type sequence E description binding site for residue SAH C 401 source : AC7 15) chain C residue 155 type sequence E description binding site for residue SAH C 401 source : AC7 16) chain C residue 166 type sequence M description binding site for residue SAH C 401 source : AC7 17) chain C residue 169 type sequence S description binding site for residue SAH C 401 source : AC7 18) chain C residue 47 type sequence Y description binding site for residue O3P C 402 source : AC8 19) chain C residue 50 type sequence C description binding site for residue O3P C 402 source : AC8 20) chain C residue 51 type sequence Y description binding site for residue O3P C 402 source : AC8 21) chain C residue 56 type sequence V description binding site for residue O3P C 402 source : AC8 22) chain C residue 59 type sequence E description binding site for residue O3P C 402 source : AC8 23) chain C residue 155 type sequence E description binding site for residue O3P C 402 source : AC8 24) chain C residue 157 type sequence M description binding site for residue O3P C 402 source : AC8 25) chain C residue 159 type sequence Y description binding site for residue O3P C 402 source : AC8 26) chain C residue 164 type sequence E description binding site for residue O3P C 402 source : AC8 27) chain C residue 317 type sequence H description binding site for residue O3P C 402 source : AC8 28) chain C residue 318 type sequence W description binding site for residue O3P C 402 source : AC8 29) chain C residue 57 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 30) chain C residue 90 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 31) chain C residue 112 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 32) chain C residue 141 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 33) chain C residue 66 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 34) chain C residue 37 type MOD_RES sequence R description Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:23866860 source Swiss-Prot : SWS_FT_FI5 35) chain C residue 155 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 36) chain C residue 164 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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