eF-site ID 6p7i-B PDB Code 6p7i Chain B click to enlarge Title Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound Classification Transferase/Transferase Inhibitor Compound Protein arginine N-methyltransferase 6 Source (ANM6_HUMAN) Sequence B:  PRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGIL RNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASA IWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSE WMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVP ISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSE IVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRF RCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPA THWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRV LLRYKVGDQEEKTKDFAMED Description Functional site 1) chain B residue 243 type sequence G description binding site for residue GOL A 403 source : AC3 2) chain B residue 246 type sequence V description binding site for residue GOL A 403 source : AC3 3) chain B residue 280 type sequence Y description binding site for residue GOL A 403 source : AC3 4) chain B residue 312 type sequence F description binding site for residue GOL A 403 source : AC3 5) chain B residue 47 type sequence Y description binding site for residue SAH B 401 source : AC4 6) chain B residue 48 type sequence Y description binding site for residue SAH B 401 source : AC4 7) chain B residue 51 type sequence Y description binding site for residue SAH B 401 source : AC4 8) chain B residue 60 type sequence M description binding site for residue SAH B 401 source : AC4 9) chain B residue 66 type sequence R description binding site for residue SAH B 401 source : AC4 10) chain B residue 90 type sequence G description binding site for residue SAH B 401 source : AC4 11) chain B residue 91 type sequence A description binding site for residue SAH B 401 source : AC4 12) chain B residue 96 type sequence L description binding site for residue SAH B 401 source : AC4 13) chain B residue 112 type sequence E description binding site for residue SAH B 401 source : AC4 14) chain B residue 113 type sequence A description binding site for residue SAH B 401 source : AC4 15) chain B residue 114 type sequence S description binding site for residue SAH B 401 source : AC4 16) chain B residue 139 type sequence P description binding site for residue SAH B 401 source : AC4 17) chain B residue 140 type sequence V description binding site for residue SAH B 401 source : AC4 18) chain B residue 141 type sequence E description binding site for residue SAH B 401 source : AC4 19) chain B residue 155 type sequence E description binding site for residue SAH B 401 source : AC4 20) chain B residue 166 type sequence M description binding site for residue SAH B 401 source : AC4 21) chain B residue 169 type sequence S description binding site for residue SAH B 401 source : AC4 22) chain B residue 47 type sequence Y description binding site for residue O3P B 402 source : AC5 23) chain B residue 50 type sequence C description binding site for residue O3P B 402 source : AC5 24) chain B residue 51 type sequence Y description binding site for residue O3P B 402 source : AC5 25) chain B residue 56 type sequence V description binding site for residue O3P B 402 source : AC5 26) chain B residue 59 type sequence E description binding site for residue O3P B 402 source : AC5 27) chain B residue 155 type sequence E description binding site for residue O3P B 402 source : AC5 28) chain B residue 157 type sequence M description binding site for residue O3P B 402 source : AC5 29) chain B residue 159 type sequence Y description binding site for residue O3P B 402 source : AC5 30) chain B residue 164 type sequence E description binding site for residue O3P B 402 source : AC5 31) chain B residue 317 type sequence H description binding site for residue O3P B 402 source : AC5 32) chain B residue 254 type sequence A description binding site for residue GOL B 403 source : AC6 33) chain B residue 255 type sequence Q description binding site for residue GOL B 403 source : AC6 34) chain B residue 271 type sequence V description binding site for residue GOL B 403 source : AC6 35) chain B residue 272 type sequence G description binding site for residue GOL B 403 source : AC6 36) chain B residue 57 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 37) chain B residue 66 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 38) chain B residue 90 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 39) chain B residue 112 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 40) chain B residue 141 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 41) chain B residue 37 type MOD_RES sequence R description Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:23866860 source Swiss-Prot : SWS_FT_FI5 42) chain B residue 155 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 43) chain B residue 164 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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