eF-site ID 6p7i-ABCD PDB Code 6p7i Chain A, B, C, D click to enlarge Title Crystal structure of Human PRMT6 in complex with S-Adenosyl-L-Homocysteine and YS17-117 Compound Classification Transferase/Transferase Inhibitor Compound Protein arginine N-methyltransferase 6 Source (ANM6_HUMAN) Sequence A:  RRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILR NWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAI WQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEW MGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPI SDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEI VVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFR CSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHW KQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLR YKVGDQEEKTKDFAMED B:  PRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGIL RNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASA IWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSE WMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVP ISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSE IVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRF RCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPA THWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRV LLRYKVGDQEEKTKDFAMED C:  RRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILR NWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAI WQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEW MGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPI SDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEI VVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFR CSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHW KQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLR YKVGDQEEKTKDFAMED D:  RPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGI LRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEAS AIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVS EWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIV PISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHS EIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGR FRCSCYGSAPMHGFAIWFQVTFPGEKPLVLSTSPFHPATH WKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLL RYKVGDQEEKTKDFAME Description Functional site 1) chain A residue 48 type sequence Y description binding site for residue SAH A 401 source : AC1 2) chain A residue 51 type sequence Y description binding site for residue SAH A 401 source : AC1 3) chain A residue 60 type sequence M description binding site for residue SAH A 401 source : AC1 4) chain A residue 66 type sequence R description binding site for residue SAH A 401 source : AC1 5) chain A residue 90 type sequence G description binding site for residue SAH A 401 source : AC1 6) chain A residue 91 type sequence A description binding site for residue SAH A 401 source : AC1 7) chain A residue 96 type sequence L description binding site for residue SAH A 401 source : AC1 8) chain A residue 112 type sequence E description binding site for residue SAH A 401 source : AC1 9) chain A residue 113 type sequence A description binding site for residue SAH A 401 source : AC1 10) chain A residue 114 type sequence S description binding site for residue SAH A 401 source : AC1 11) chain A residue 139 type sequence P description binding site for residue SAH A 401 source : AC1 12) chain A residue 140 type sequence V description binding site for residue SAH A 401 source : AC1 13) chain A residue 141 type sequence E description binding site for residue SAH A 401 source : AC1 14) chain A residue 155 type sequence E description binding site for residue SAH A 401 source : AC1 15) chain A residue 166 type sequence M description binding site for residue SAH A 401 source : AC1 16) chain A residue 169 type sequence S description binding site for residue SAH A 401 source : AC1 17) chain A residue 47 type sequence Y description binding site for residue O3P A 402 source : AC2 18) chain A residue 50 type sequence C description binding site for residue O3P A 402 source : AC2 19) chain A residue 51 type sequence Y description binding site for residue O3P A 402 source : AC2 20) chain A residue 56 type sequence V description binding site for residue O3P A 402 source : AC2 21) chain A residue 59 type sequence E description binding site for residue O3P A 402 source : AC2 22) chain A residue 155 type sequence E description binding site for residue O3P A 402 source : AC2 23) chain A residue 157 type sequence M description binding site for residue O3P A 402 source : AC2 24) chain A residue 159 type sequence Y description binding site for residue O3P A 402 source : AC2 25) chain A residue 164 type sequence E description binding site for residue O3P A 402 source : AC2 26) chain A residue 317 type sequence H description binding site for residue O3P A 402 source : AC2 27) chain A residue 242 type sequence S description binding site for residue GOL A 403 source : AC3 28) chain A residue 243 type sequence G description binding site for residue GOL A 403 source : AC3 29) chain A residue 311 type sequence P description binding site for residue GOL A 403 source : AC3 30) chain B residue 243 type sequence G description binding site for residue GOL A 403 source : AC3 31) chain B residue 246 type sequence V description binding site for residue GOL A 403 source : AC3 32) chain B residue 280 type sequence Y description binding site for residue GOL A 403 source : AC3 33) chain B residue 312 type sequence F description binding site for residue GOL A 403 source : AC3 34) chain B residue 47 type sequence Y description binding site for residue SAH B 401 source : AC4 35) chain B residue 48 type sequence Y description binding site for residue SAH B 401 source : AC4 36) chain B residue 51 type sequence Y description binding site for residue SAH B 401 source : AC4 37) chain B residue 60 type sequence M description binding site for residue SAH B 401 source : AC4 38) chain B residue 66 type sequence R description binding site for residue SAH B 401 source : AC4 39) chain B residue 90 type sequence G description binding site for residue SAH B 401 source : AC4 40) chain B residue 91 type sequence A description binding site for residue SAH B 401 source : AC4 41) chain B residue 96 type sequence L description binding site for residue SAH B 401 source : AC4 42) chain B residue 112 type sequence E description binding site for residue SAH B 401 source : AC4 43) chain B residue 113 type sequence A description binding site for residue SAH B 401 source : AC4 44) chain B residue 114 type sequence S description binding site for residue SAH B 401 source : AC4 45) chain B residue 139 type sequence P description binding site for residue SAH B 401 source : AC4 46) chain B residue 140 type sequence V description binding site for residue SAH B 401 source : AC4 47) chain B residue 141 type sequence E description binding site for residue SAH B 401 source : AC4 48) chain B residue 155 type sequence E description binding site for residue SAH B 401 source : AC4 49) chain B residue 166 type sequence M description binding site for residue SAH B 401 source : AC4 50) chain B residue 169 type sequence S description binding site for residue SAH B 401 source : AC4 51) chain B residue 47 type sequence Y description binding site for residue O3P B 402 source : AC5 52) chain B residue 50 type sequence C description binding site for residue O3P B 402 source : AC5 53) chain B residue 51 type sequence Y description binding site for residue O3P B 402 source : AC5 54) chain B residue 56 type sequence V description binding site for residue O3P B 402 source : AC5 55) chain B residue 59 type sequence E description binding site for residue O3P B 402 source : AC5 56) chain B residue 155 type sequence E description binding site for residue O3P B 402 source : AC5 57) chain B residue 157 type sequence M description binding site for residue O3P B 402 source : AC5 58) chain B residue 159 type sequence Y description binding site for residue O3P B 402 source : AC5 59) chain B residue 164 type sequence E description binding site for residue O3P B 402 source : AC5 60) chain B residue 317 type sequence H description binding site for residue O3P B 402 source : AC5 61) chain B residue 254 type sequence A description binding site for residue GOL B 403 source : AC6 62) chain B residue 255 type sequence Q description binding site for residue GOL B 403 source : AC6 63) chain B residue 271 type sequence V description binding site for residue GOL B 403 source : AC6 64) chain B residue 272 type sequence G description binding site for residue GOL B 403 source : AC6 65) chain C residue 48 type sequence Y description binding site for residue SAH C 401 source : AC7 66) chain C residue 51 type sequence Y description binding site for residue SAH C 401 source : AC7 67) chain C residue 60 type sequence M description binding site for residue SAH C 401 source : AC7 68) chain C residue 66 type sequence R description binding site for residue SAH C 401 source : AC7 69) chain C residue 90 type sequence G description binding site for residue SAH C 401 source : AC7 70) chain C residue 91 type sequence A description binding site for residue SAH C 401 source : AC7 71) chain C residue 95 type sequence I description binding site for residue SAH C 401 source : AC7 72) chain C residue 96 type sequence L description binding site for residue SAH C 401 source : AC7 73) chain C residue 112 type sequence E description binding site for residue SAH C 401 source : AC7 74) chain C residue 113 type sequence A description binding site for residue SAH C 401 source : AC7 75) chain C residue 114 type sequence S description binding site for residue SAH C 401 source : AC7 76) chain C residue 139 type sequence P description binding site for residue SAH C 401 source : AC7 77) chain C residue 140 type sequence V description binding site for residue SAH C 401 source : AC7 78) chain C residue 141 type sequence E description binding site for residue SAH C 401 source : AC7 79) chain C residue 155 type sequence E description binding site for residue SAH C 401 source : AC7 80) chain C residue 166 type sequence M description binding site for residue SAH C 401 source : AC7 81) chain C residue 169 type sequence S description binding site for residue SAH C 401 source : AC7 82) chain C residue 47 type sequence Y description binding site for residue O3P C 402 source : AC8 83) chain C residue 50 type sequence C description binding site for residue O3P C 402 source : AC8 84) chain C residue 51 type sequence Y description binding site for residue O3P C 402 source : AC8 85) chain C residue 56 type sequence V description binding site for residue O3P C 402 source : AC8 86) chain C residue 59 type sequence E description binding site for residue O3P C 402 source : AC8 87) chain C residue 155 type sequence E description binding site for residue O3P C 402 source : AC8 88) chain C residue 157 type sequence M description binding site for residue O3P C 402 source : AC8 89) chain C residue 159 type sequence Y description binding site for residue O3P C 402 source : AC8 90) chain C residue 164 type sequence E description binding site for residue O3P C 402 source : AC8 91) chain C residue 317 type sequence H description binding site for residue O3P C 402 source : AC8 92) chain C residue 318 type sequence W description binding site for residue O3P C 402 source : AC8 93) chain D residue 48 type sequence Y description binding site for residue SAH D 401 source : AC9 94) chain D residue 51 type sequence Y description binding site for residue SAH D 401 source : AC9 95) chain D residue 60 type sequence M description binding site for residue SAH D 401 source : AC9 96) chain D residue 66 type sequence R description binding site for residue SAH D 401 source : AC9 97) chain D residue 90 type sequence G description binding site for residue SAH D 401 source : AC9 98) chain D residue 91 type sequence A description binding site for residue SAH D 401 source : AC9 99) chain D residue 95 type sequence I description binding site for residue SAH D 401 source : AC9 100) chain D residue 96 type sequence L description binding site for residue SAH D 401 source : AC9 101) chain D residue 112 type sequence E description binding site for residue SAH D 401 source : AC9 102) chain D residue 113 type sequence A description binding site for residue SAH D 401 source : AC9 103) chain D residue 114 type sequence S description binding site for residue SAH D 401 source : AC9 104) chain D residue 138 type sequence G description binding site for residue SAH D 401 source : AC9 105) chain D residue 139 type sequence P description binding site for residue SAH D 401 source : AC9 106) chain D residue 140 type sequence V description binding site for residue SAH D 401 source : AC9 107) chain D residue 141 type sequence E description binding site for residue SAH D 401 source : AC9 108) chain D residue 155 type sequence E description binding site for residue SAH D 401 source : AC9 109) chain D residue 166 type sequence M description binding site for residue SAH D 401 source : AC9 110) chain D residue 169 type sequence S description binding site for residue SAH D 401 source : AC9 111) chain D residue 46 type sequence L description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 112) chain D residue 47 type sequence Y description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 113) chain D residue 48 type sequence Y description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 114) chain D residue 49 type sequence E description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 115) chain D residue 51 type sequence Y description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 116) chain D residue 52 type sequence S description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 117) chain D residue 53 type sequence D description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 118) chain D residue 59 type sequence E description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 119) chain D residue 155 type sequence E description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 120) chain D residue 157 type sequence M description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 121) chain D residue 159 type sequence Y description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 122) chain D residue 164 type sequence E description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 123) chain D residue 317 type sequence H description binding site for Di-peptide O3S D 402 and CYS D 50 source : AD1 124) chain A residue 57 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 125) chain B residue 57 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 126) chain C residue 57 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 127) chain D residue 57 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 128) chain A residue 66 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 129) chain C residue 90 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 130) chain C residue 112 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 131) chain C residue 141 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 132) chain D residue 66 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 133) chain D residue 90 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 134) chain D residue 112 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 135) chain D residue 141 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 136) chain A residue 90 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 137) chain A residue 112 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 138) chain A residue 141 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 139) chain B residue 66 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 140) chain B residue 90 type BINDING sequence G description source Swiss-Prot : SWS_FT_FI3 141) chain B residue 112 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 142) chain B residue 141 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI3 143) chain C residue 66 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 144) chain D residue 35 type MOD_RES sequence R description Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:23866860 source Swiss-Prot : SWS_FT_FI5 145) chain D residue 37 type MOD_RES sequence R description Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:23866860 source Swiss-Prot : SWS_FT_FI5 146) chain A residue 37 type MOD_RES sequence R description Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:23866860 source Swiss-Prot : SWS_FT_FI5 147) chain B residue 37 type MOD_RES sequence R description Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:23866860 source Swiss-Prot : SWS_FT_FI5 148) chain C residue 37 type MOD_RES sequence R description Asymmetric dimethylarginine; by autocatalysis => ECO:0000269|PubMed:23866860 source Swiss-Prot : SWS_FT_FI5 149) chain A residue 155 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 150) chain A residue 164 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 151) chain B residue 155 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 152) chain B residue 164 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 153) chain C residue 155 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 154) chain C residue 164 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 155) chain D residue 155 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 156) chain D residue 164 type ACT_SITE sequence E description ACT_SITE => ECO:0000250 source Swiss-Prot : SWS_FT_FI1

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