eF-site ID 6p69-B
PDB Code 6p69
Chain B

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Title Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 11.
Classification TRANSFERASE
Compound Fibroblast growth factor receptor 1
Source (FGFR1_HUMAN)
Sequence B:  SEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGL
PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI
INLLGACTQDGPLYVIVECASKGNLREYLQARRPPEEQLS
SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV
MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI
YTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEG
HRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR
IVALTS
Description (1)  Fibroblast growth factor receptor 1 (E.C.2.7.10.1)


Functional site

1) chain B
residue 570
type
ligand
sequence R
description binding site for residue SO4 B 801
source : AC5

2) chain B
residue 627
type
ligand
sequence R
description binding site for residue SO4 B 801
source : AC5

3) chain B
residue 657
type
ligand
sequence T
description binding site for residue SO4 B 801
source : AC5

4) chain B
residue 659
type
ligand
sequence N
description binding site for residue SO4 B 801
source : AC5

5) chain B
residue 661
type
ligand
sequence R
description binding site for residue SO4 B 801
source : AC5

6) chain B
residue 574
type
ligand
sequence Q
description binding site for residue SO4 B 802
source : AC6

7) chain B
residue 659
type
ligand
sequence N
description binding site for residue SO4 B 802
source : AC6

8) chain B
residue 661
type
ligand
sequence R
description binding site for residue SO4 B 802
source : AC6

9) chain B
residue 699
type
ligand
sequence S
description binding site for residue SO4 B 802
source : AC6

10) chain B
residue 684
type
ligand
sequence W
description binding site for residue EDO B 803
source : AC7

11) chain B
residue 701
type
ligand
sequence Y
description binding site for residue EDO B 803
source : AC7

12) chain B
residue 713
type
ligand
sequence L
description binding site for residue EDO B 803
source : AC7

13) chain B
residue 718
type
ligand
sequence R
description binding site for residue EDO B 803
source : AC7

14) chain B
residue 719
type
ligand
sequence M
description binding site for residue EDO B 803
source : AC7

15) chain B
residue 737
type
ligand
sequence W
description binding site for residue EDO B 803
source : AC7

16) chain B
residue 484
type
ligand
sequence L
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

17) chain B
residue 492
type
ligand
sequence V
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

18) chain B
residue 494
type
ligand
sequence L
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

19) chain B
residue 510
type
ligand
sequence K
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

20) chain B
residue 514
type
ligand
sequence K
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

21) chain B
residue 531
type
ligand
sequence E
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

22) chain B
residue 535
type
ligand
sequence M
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

23) chain B
residue 559
type
ligand
sequence V
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

24) chain B
residue 561
type
ligand
sequence V
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

25) chain B
residue 562
type
ligand
sequence E
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

26) chain B
residue 564
type
ligand
sequence A
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

27) chain B
residue 565
type
ligand
sequence S
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

28) chain B
residue 630
type
ligand
sequence L
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

29) chain B
residue 640
type
ligand
sequence A
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

30) chain B
residue 641
type
ligand
sequence D
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

31) chain B
residue 642
type
ligand
sequence F
description binding site for Di-peptide O21 B 804 and CYS B 563
source : AC8

32) chain B
residue 484-514
type prosite
ligand
sequence LGEGAFGQVVLAEAIGLPNRVTKVAVK
description Protein kinases ATP-binding region signature.[LIV]-G-{P}-G-{P}-[FYWMGSTNH]-[SGA]-{PW}-[LIVCAT]-{PD}-x-[GSTACLIVMFY]-x(5,18)-[LIVMFYWCSTAR]-[AIVP]-[LIVMFAGCKR]-K.
source prosite : PS00107

33) chain B
residue 619-631
type prosite
ligand
sequence CIHRDLAARNVLV
description Tyrosine protein kinases specific active-site signature.[LIVMFYC]-{A}-[HY]-x-D-[LIVMFY]-[RSTAC]-{D}-{PF}-N-[LIVMFYC](3).
source prosite : PS00109


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