eF-site ID 6p69-B PDB Code 6p69 Chain B click to enlarge Title Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 11. Classification TRANSFERASE Compound Fibroblast growth factor receptor 1 Source (FGFR1_HUMAN) Sequence B:  SEYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGL PNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNI INLLGACTQDGPLYVIVECASKGNLREYLQARRPPEEQLS SKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNV MKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRI YTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEG HRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDR IVALTS Description Functional site 1) chain B residue 570 type sequence R description binding site for residue SO4 B 801 source : AC5 2) chain B residue 627 type sequence R description binding site for residue SO4 B 801 source : AC5 3) chain B residue 657 type sequence T description binding site for residue SO4 B 801 source : AC5 4) chain B residue 659 type sequence N description binding site for residue SO4 B 801 source : AC5 5) chain B residue 661 type sequence R description binding site for residue SO4 B 801 source : AC5 6) chain B residue 574 type sequence Q description binding site for residue SO4 B 802 source : AC6 7) chain B residue 659 type sequence N description binding site for residue SO4 B 802 source : AC6 8) chain B residue 661 type sequence R description binding site for residue SO4 B 802 source : AC6 9) chain B residue 699 type sequence S description binding site for residue SO4 B 802 source : AC6 10) chain B residue 684 type sequence W description binding site for residue EDO B 803 source : AC7 11) chain B residue 701 type sequence Y description binding site for residue EDO B 803 source : AC7 12) chain B residue 713 type sequence L description binding site for residue EDO B 803 source : AC7 13) chain B residue 718 type sequence R description binding site for residue EDO B 803 source : AC7 14) chain B residue 719 type sequence M description binding site for residue EDO B 803 source : AC7 15) chain B residue 737 type sequence W description binding site for residue EDO B 803 source : AC7 16) chain B residue 484 type sequence L description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 17) chain B residue 492 type sequence V description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 18) chain B residue 494 type sequence L description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 19) chain B residue 510 type sequence K description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 20) chain B residue 514 type sequence K description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 21) chain B residue 531 type sequence E description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 22) chain B residue 535 type sequence M description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 23) chain B residue 559 type sequence V description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 24) chain B residue 561 type sequence V description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 25) chain B residue 562 type sequence E description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 26) chain B residue 564 type sequence A description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 27) chain B residue 565 type sequence S description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 28) chain B residue 630 type sequence L description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 29) chain B residue 640 type sequence A description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 30) chain B residue 641 type sequence D description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8 31) chain B residue 642 type sequence F description binding site for Di-peptide O21 B 804 and CYS B 563 source : AC8

Display surface Download Links