eF-site ID 6p69-A PDB Code 6p69 Chain A click to enlarge Title Crystal structure of FGFR1-Y563C (FGFR4 surrogate) covalently bound to compound 11. Classification TRANSFERASE Compound Fibroblast growth factor receptor 1 Source (FGFR1_HUMAN) Sequence A:  EYELPEDPRWELPRDRLVLGKPLGEGAFGQVVLAEAIGLP NRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNII NLLGACTQDGPLYVIVECASKGNLREYLQARRPPEEQLSS KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVM KIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIY THQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRI VALTSNQE Description Functional site 1) chain A residue 570 type sequence R description binding site for residue SO4 A 801 source : AC1 2) chain A residue 627 type sequence R description binding site for residue SO4 A 801 source : AC1 3) chain A residue 657 type sequence T description binding site for residue SO4 A 801 source : AC1 4) chain A residue 659 type sequence N description binding site for residue SO4 A 801 source : AC1 5) chain A residue 661 type sequence R description binding site for residue SO4 A 801 source : AC1 6) chain A residue 615 type sequence A description binding site for residue EDO A 802 source : AC2 7) chain A residue 746 type sequence T description binding site for residue EDO A 802 source : AC2 8) chain A residue 747 type sequence F description binding site for residue EDO A 802 source : AC2 9) chain A residue 748 type sequence K description binding site for residue EDO A 802 source : AC2 10) chain A residue 684 type sequence W description binding site for residue EDO A 803 source : AC3 11) chain A residue 701 type sequence Y description binding site for residue EDO A 803 source : AC3 12) chain A residue 718 type sequence R description binding site for residue EDO A 803 source : AC3 13) chain A residue 719 type sequence M description binding site for residue EDO A 803 source : AC3 14) chain A residue 737 type sequence W description binding site for residue EDO A 803 source : AC3 15) chain A residue 484 type sequence L description binding site for residue O21 A 804 source : AC4 16) chain A residue 486 type sequence E description binding site for residue O21 A 804 source : AC4 17) chain A residue 487 type sequence G description binding site for residue O21 A 804 source : AC4 18) chain A residue 492 type sequence V description binding site for residue O21 A 804 source : AC4 19) chain A residue 494 type sequence L description binding site for residue O21 A 804 source : AC4 20) chain A residue 512 type sequence A description binding site for residue O21 A 804 source : AC4 21) chain A residue 514 type sequence K description binding site for residue O21 A 804 source : AC4 22) chain A residue 531 type sequence E description binding site for residue O21 A 804 source : AC4 23) chain A residue 559 type sequence V description binding site for residue O21 A 804 source : AC4 24) chain A residue 561 type sequence V description binding site for residue O21 A 804 source : AC4 25) chain A residue 562 type sequence E description binding site for residue O21 A 804 source : AC4 26) chain A residue 563 type sequence C description binding site for residue O21 A 804 source : AC4 27) chain A residue 564 type sequence A description binding site for residue O21 A 804 source : AC4 28) chain A residue 630 type sequence L description binding site for residue O21 A 804 source : AC4 29) chain A residue 640 type sequence A description binding site for residue O21 A 804 source : AC4 30) chain A residue 641 type sequence D description binding site for residue O21 A 804 source : AC4 31) chain A residue 484-514 type prosite sequence LGEGAFGQVVLAEAIGLPNRVTKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGAFGQVVlAeaigldkdkpnrvtk...VAVK source prosite : PS00107 32) chain A residue 623 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 562 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 34) chain A residue 568 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI2 35) chain A residue 627 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI2 36) chain A residue 641 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 37) chain A residue 484 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 38) chain A residue 514 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 39) chain A residue 463 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI3 40) chain A residue 730 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI5 41) chain A residue 653 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI4 42) chain A residue 654 type MOD_RES sequence Y description Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:8622701 source Swiss-Prot : SWS_FT_FI4 43) chain A residue 619-631 type prosite sequence CIHRDLAARNVLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV source prosite : PS00109

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