eF-site ID 6p3p-A PDB Code 6p3p Chain A click to enlarge Title Crystal structure of Mcl-1 in complex with compound 65 Classification APOPTOSIS/APOPTOSIS INHIBITOR Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source (MCL1_HUMAN) Sequence A:  SDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKAL ETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVM IHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL AESITDVLVRTKRDWLVKQRGWDGFVEFFH Description Functional site 1) chain A residue 220 type sequence V description binding site for residue NQJ A 501 source : AC1 2) chain A residue 224 type sequence H description binding site for residue NQJ A 501 source : AC1 3) chain A residue 227 type sequence A description binding site for residue NQJ A 501 source : AC1 4) chain A residue 250 type sequence M description binding site for residue NQJ A 501 source : AC1 5) chain A residue 254 type sequence F description binding site for residue NQJ A 501 source : AC1 6) chain A residue 260 type sequence N description binding site for residue NQJ A 501 source : AC1 7) chain A residue 262 type sequence G description binding site for residue NQJ A 501 source : AC1 8) chain A residue 263 type sequence R description binding site for residue NQJ A 501 source : AC1 9) chain A residue 266 type sequence T description binding site for residue NQJ A 501 source : AC1 10) chain A residue 267 type sequence L description binding site for residue NQJ A 501 source : AC1 11) chain A residue 194 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 12) chain A residue 197 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 13) chain A residue 253-272 type prosite sequence VFSDGVTNWGRIVTLISFGA description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA source prosite : PS01080 14) chain A residue 305-316 type prosite sequence WLVKQRGWDGFV description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV source prosite : PS01258 15) chain A residue 209-223 type prosite sequence ALETLRRVGDGVQRN description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN source prosite : PS01259

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