eF-site ID 6p11-B PDB Code 6p11 Chain B click to enlarge Title Structure of spastin AAA domain (T692A mutant) in complex with JNJ-7706621 inhibitor Classification ISOMERASE/ISOMERASE INHIBITOR Compound Drosophila melanogaster Spastin AAA domain Source (SPAST_DROME) Sequence B:  GVEQKLVQLILDEIVEGGAKVEWTDIAGQDVAKQALQEMV ILPSVRPELFTGLRAPAKGLLLFGPPGNGKTLLARAVATE CSATFLNISAASLTSKYGEKLVRALFAVARHMQPSIIFID EVDSLLSRRLKTEFLVEFDGLPGGDRIVVLAATNRPQELD EAALRRFTKRVYVSLPDEQTRELLLNRLLQKQGSPLDTEA LRRLAKITDGYSGSDLAALAKDAALEPIRELNVEQVKCLD ISAMRAITEQDFHSSLKRIRRSVAPQSLNSYEKWSQDYGD Description Functional site 1) chain B residue 526 type sequence G description binding site for residue SO4 B 801 source : AC1 2) chain B residue 527 type sequence N description binding site for residue SO4 B 801 source : AC1 3) chain B residue 528 type sequence G description binding site for residue SO4 B 801 source : AC1 4) chain B residue 529 type sequence K description binding site for residue SO4 B 801 source : AC1 5) chain B residue 530 type sequence T description binding site for residue SO4 B 801 source : AC1 6) chain B residue 484 type sequence D description binding site for residue SKE B 802 source : AC2 7) chain B residue 485 type sequence I description binding site for residue SKE B 802 source : AC2 8) chain B residue 486 type sequence A description binding site for residue SKE B 802 source : AC2 9) chain B residue 526 type sequence G description binding site for residue SKE B 802 source : AC2 10) chain B residue 527 type sequence N description binding site for residue SKE B 802 source : AC2 11) chain B residue 528 type sequence G description binding site for residue SKE B 802 source : AC2 12) chain B residue 531 type sequence L description binding site for residue SKE B 802 source : AC2 13) chain B residue 534 type sequence R description binding site for residue SKE B 802 source : AC2 14) chain B residue 659 type sequence L description binding site for residue SKE B 802 source : AC2 15) chain B residue 662 type sequence R description binding site for residue SKE B 802 source : AC2 16) chain B residue 663 type sequence L description binding site for residue SKE B 802 source : AC2 17) chain B residue 666 type sequence K description binding site for residue SKE B 802 source : AC2 18) chain B residue 688 type sequence G description binding site for residue SKE B 802 source : AC2 19) chain B residue 689 type sequence S description binding site for residue SKE B 802 source : AC2 20) chain B residue 472 type sequence E description binding site for residue MPD B 803 source : AC3 21) chain B residue 551 type sequence S description binding site for residue MPD B 803 source : AC3 22) chain B residue 552 type sequence L description binding site for residue MPD B 803 source : AC3 23) chain B residue 555 type sequence K description binding site for residue MPD B 803 source : AC3 24) chain B residue 641 type sequence R description binding site for residue MPD B 803 source : AC3 25) chain B residue 523 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_03021 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 622-641 type prosite sequence IVVLAATNRPQELDEAALRR description AAA AAA-protein family signature. IvVLaATNrpqeLDeAAlrR source prosite : PS00674

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