eF-site ID 6p0r-AB PDB Code 6p0r Chain A, B click to enlarge Title Methyltransferase domain of human suppressor of variegation 3-9 homolog 2 (SUV39H2) in complex with OTS186935 inhibitor Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Histone-lysine N-methyltransferase SUV39H2 Source (SUV92_HUMAN) Sequence A:  AKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFY YINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLL AYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQY SLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEA ERRGQFYGITYLFDLDYESDEFTVDAARYGNVSHFVNHSC DPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQ MKRTVCKCVTCRGYL B:  KQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYY INEYKPAPATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQI KIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTS NGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFIT YLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVF IDNLDTRLPRIALFSTRTINAGEELTFDYQ Description Functional site 1) chain A residue 280 type sequence Y description binding site for residue NM4 A 501 source : AC1 2) chain A residue 302 type sequence I description binding site for residue NM4 A 501 source : AC1 3) chain A residue 303 type sequence T description binding site for residue NM4 A 501 source : AC1 4) chain A residue 304 type sequence Y description binding site for residue NM4 A 501 source : AC1 5) chain A residue 305 type sequence L description binding site for residue NM4 A 501 source : AC1 6) chain A residue 326 type sequence S description binding site for residue NM4 A 501 source : AC1 7) chain A residue 327 type sequence H description binding site for residue NM4 A 501 source : AC1 8) chain A residue 329 type sequence V description binding site for residue NM4 A 501 source : AC1 9) chain A residue 356 type sequence L description binding site for residue NM4 A 501 source : AC1 10) chain A residue 370 type sequence F description binding site for residue NM4 A 501 source : AC1 11) chain A residue 372 type sequence Y description binding site for residue NM4 A 501 source : AC1 12) chain A residue 333 type sequence C description binding site for residue ZN A 502 source : AC2 13) chain A residue 398 type sequence C description binding site for residue ZN A 502 source : AC2 14) chain A residue 400 type sequence C description binding site for residue ZN A 502 source : AC2 15) chain A residue 405 type sequence C description binding site for residue ZN A 502 source : AC2 16) chain A residue 191 type sequence C description binding site for residue ZN A 503 source : AC3 17) chain A residue 193 type sequence C description binding site for residue ZN A 503 source : AC3 18) chain A residue 196 type sequence C description binding site for residue ZN A 503 source : AC3 19) chain A residue 201 type sequence C description binding site for residue ZN A 503 source : AC3 20) chain A residue 191 type sequence C description binding site for residue ZN A 504 source : AC4 21) chain A residue 202 type sequence C description binding site for residue ZN A 504 source : AC4 22) chain A residue 229 type sequence C description binding site for residue ZN A 504 source : AC4 23) chain A residue 233 type sequence C description binding site for residue ZN A 504 source : AC4 24) chain A residue 196 type sequence C description binding site for residue ZN A 505 source : AC5 25) chain A residue 229 type sequence C description binding site for residue ZN A 505 source : AC5 26) chain A residue 235 type sequence C description binding site for residue ZN A 505 source : AC5 27) chain A residue 239 type sequence C description binding site for residue ZN A 505 source : AC5 28) chain B residue 280 type sequence Y description binding site for residue NM4 B 501 source : AC6 29) chain B residue 302 type sequence I description binding site for residue NM4 B 501 source : AC6 30) chain B residue 303 type sequence T description binding site for residue NM4 B 501 source : AC6 31) chain B residue 304 type sequence Y description binding site for residue NM4 B 501 source : AC6 32) chain B residue 305 type sequence L description binding site for residue NM4 B 501 source : AC6 33) chain B residue 306 type sequence F description binding site for residue NM4 B 501 source : AC6 34) chain B residue 326 type sequence S description binding site for residue NM4 B 501 source : AC6 35) chain B residue 327 type sequence H description binding site for residue NM4 B 501 source : AC6 36) chain B residue 329 type sequence V description binding site for residue NM4 B 501 source : AC6 37) chain B residue 356 type sequence L description binding site for residue NM4 B 501 source : AC6 38) chain B residue 370 type sequence F description binding site for residue NM4 B 501 source : AC6 39) chain B residue 372 type sequence Y description binding site for residue NM4 B 501 source : AC6 40) chain B residue 191 type sequence C description binding site for residue ZN B 502 source : AC7 41) chain B residue 193 type sequence C description binding site for residue ZN B 502 source : AC7 42) chain B residue 196 type sequence C description binding site for residue ZN B 502 source : AC7 43) chain B residue 201 type sequence C description binding site for residue ZN B 502 source : AC7 44) chain B residue 191 type sequence C description binding site for residue ZN B 503 source : AC8 45) chain B residue 202 type sequence C description binding site for residue ZN B 503 source : AC8 46) chain B residue 229 type sequence C description binding site for residue ZN B 503 source : AC8 47) chain B residue 233 type sequence C description binding site for residue ZN B 503 source : AC8 48) chain B residue 196 type sequence C description binding site for residue ZN B 504 source : AC9 49) chain B residue 229 type sequence C description binding site for residue ZN B 504 source : AC9 50) chain B residue 235 type sequence C description binding site for residue ZN B 504 source : AC9 51) chain B residue 239 type sequence C description binding site for residue ZN B 504 source : AC9 52) chain A residue 251 type BINDING sequence S description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 53) chain A residue 321 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 54) chain B residue 251 type BINDING sequence S description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 55) chain B residue 253 type BINDING sequence C description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 56) chain B residue 256 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 57) chain B residue 261 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 58) chain B residue 262 type BINDING sequence G description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 59) chain B residue 289 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 60) chain B residue 293 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 61) chain A residue 253 type BINDING sequence C description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 62) chain B residue 295 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 63) chain B residue 321 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 64) chain A residue 256 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 65) chain A residue 261 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 66) chain A residue 262 type BINDING sequence G description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 67) chain A residue 289 type BINDING sequence E description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 68) chain A residue 293 type BINDING sequence R description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1 69) chain A residue 295 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:20084102, ECO:0007744|PDB:2R3A source Swiss-Prot : SWS_FT_FI1

Display surface Download Links