eF-site ID 6ozl-ABCD PDB Code 6ozl Chain A, B, C, D click to enlarge Title Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 2 min soak in Mn2+ Classification HYDROLASE Compound Endonuclease V Source (6OZL) Sequence A:  ERPPEETLSLWKGEQARLKARVVDRDTEAWQRDPSFSGLQ KVGGVDVSFVKSVRACASLVVLSYPELKVVYEDSRMVGLK APYVSGFLAFREVPFLVELVQRLQEKEPDLMPQVVLVDGN GVLHQRGFGVACHLGVLTELPCIGVAKKLLQVDGLENNAL HKEKIVLLQAGGDTFPLIGSSGTVLGMALRSHDHSTKPLY VSVGHRISLEVAVRLTHHCCRFRIPEPIRQADIRSREYIR RTL B:  RPPEETLSLWKGEQARLKARVVDRDTEAWQRDPSFSGLQK VGGVDVSFVKGDSVRACASLVVLSYPELKVVYEDSRMVGL KAPYVSGFLAFREVPFLVELVQRLQEKEPDLMPQVVLVDG NGVLHQRGFGVACHLGVLTELPCIGVAKKLLQVDGLENNA LHKEKIVLLQAGGDTFPLIGSSGTVLGMALRSHDHSTKPL YVSVGHRISLEVAVRLTHHCCRFRIPEPIRQADIRSREYI RRTL C:  CXAUAUGCAUGCAUU D:  CCXAUAUGCAUGCAUU Description Functional site 1) chain A residue 52 type sequence D description binding site for residue MN A 301 source : AC1 2) chain A residue 240 type sequence D description binding site for residue MN A 301 source : AC1 3) chain C residue 12 type sequence U description binding site for residue MN A 301 source : AC1 4) chain A residue 52 type sequence D description binding site for residue MN A 302 source : AC2 5) chain A residue 126 type sequence D description binding site for residue MN A 302 source : AC2 6) chain C residue 11 type sequence A description binding site for residue MN A 302 source : AC2 7) chain C residue 12 type sequence U description binding site for residue MN A 302 source : AC2 8) chain A residue 32 type sequence D description binding site for residue GOL A 303 source : AC3 9) chain A residue 38 type sequence R description binding site for residue GOL A 303 source : AC3 10) chain B residue 145 type sequence L description binding site for residue GOL A 303 source : AC3 11) chain B residue 147 type sequence E description binding site for residue GOL A 303 source : AC3 12) chain A residue 225 type sequence H description binding site for residue PGE A 304 source : AC4 13) chain A residue 226 type sequence H description binding site for residue PGE A 304 source : AC4 14) chain A residue 228 type sequence C description binding site for residue PGE A 304 source : AC4 15) chain A residue 229 type sequence R description binding site for residue PGE A 304 source : AC4 16) chain A residue 45 type sequence L description binding site for residue NA A 305 source : AC5 17) chain A residue 46 type sequence Q description binding site for residue NA A 305 source : AC5 18) chain B residue 52 type sequence D description binding site for residue MN B 301 source : AC6 19) chain B residue 240 type sequence D description binding site for residue MN B 301 source : AC6 20) chain D residue 12 type sequence U description binding site for residue MN B 301 source : AC6 21) chain B residue 52 type sequence D description binding site for residue MN B 302 source : AC7 22) chain B residue 126 type sequence D description binding site for residue MN B 302 source : AC7 23) chain D residue 11 type sequence A description binding site for residue MN B 302 source : AC7 24) chain D residue 12 type sequence U description binding site for residue MN B 302 source : AC7 25) chain B residue 226 type sequence H description binding site for residue PGE B 303 source : AC8 26) chain B residue 228 type sequence C description binding site for residue PGE B 303 source : AC8 27) chain B residue 229 type sequence R description binding site for residue PGE B 303 source : AC8 28) chain C residue 17 type sequence A description binding site for residue GOL C 101 source : AC9 29) chain C residue 18 type sequence U description binding site for residue GOL C 101 source : AC9 30) chain C residue 19 type sequence G description binding site for residue GOL C 101 source : AC9 31) chain D residue 17 type sequence A description binding site for residue TLA D 101 source : AD1 32) chain D residue 18 type sequence U description binding site for residue TLA D 101 source : AD1 33) chain D residue 19 type sequence G description binding site for residue TLA D 101 source : AD1 34) chain A residue 52 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 35) chain A residue 126 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 52 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 126 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 38) chain A residue 91 type SITE sequence Y description Interaction with target DNA => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 39) chain B residue 91 type SITE sequence Y description Interaction with target DNA => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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