eF-site ID 6ovc-A PDB Code 6ovc Chain A click to enlarge Title hMcl1 inhibitor complex Classification APOPTOSIS/INHIBITOR Compound Induced myeloid leukemia cell differentiation protein Mcl-1 Source (MCL1_HUMAN) Sequence A:  MEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKA LETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRV MIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESSIEP LAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGHH HHHH Description (1)  Induced myeloid leukemia cell differentiation protein Mcl-1 Functional site 1) chain A residue 55 type sequence H description binding site for residue N8J A 201 source : AC1 2) chain A residue 62 type sequence M description binding site for residue N8J A 201 source : AC1 3) chain A residue 66 type sequence L description binding site for residue N8J A 201 source : AC1 4) chain A residue 84 type sequence V description binding site for residue N8J A 201 source : AC1 5) chain A residue 94 type sequence R description binding site for residue N8J A 201 source : AC1 6) chain A residue 97 type sequence T description binding site for residue N8J A 201 source : AC1 7) chain A residue 98 type sequence L description binding site for residue N8J A 201 source : AC1 8) chain A residue 101 type sequence F description binding site for residue N8J A 201 source : AC1 9) chain A residue 25 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 10) chain A residue 28 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) source Swiss-Prot : SWS_FT_FI1 11) chain A residue 84-103 type prosite sequence VFSDGVTNWGRIVTLISFGA description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA source prosite : PS01080 12) chain A residue 136-147 type prosite sequence WLVKQRGWDGFV description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV source prosite : PS01258 13) chain A residue 40-54 type prosite sequence ALETLRRVGDGVQRN description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN source prosite : PS01259

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