eF-site ID 6ot5-B PDB Code 6ot5 Chain B click to enlarge Title Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution Classification TRANSPORT PROTEIN Compound Transient receptor potential cation channel subfamily V member 3,Transient receptor potential cation channel subfamily V member 3 Source (TRPV3_HUMAN) Sequence B:  XXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEELVE LLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNINP NTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNI AIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYF GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILH ALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDG LTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWA YGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLT LEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYY RGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFVFF IQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTR GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALAS LIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQN SKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKE SERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDD FRLCLRINEVKWTEWKTHVSFLN Description (1)  Transient receptor potential cation channel subfamily V member 3 Functional site 1) chain B residue 417 type sequence H description binding site for residue FZ4 B 1001 source : AC2 2) chain B residue 420 type sequence L description binding site for residue FZ4 B 1001 source : AC2 3) chain B residue 421 type sequence T description binding site for residue FZ4 B 1001 source : AC2 4) chain B residue 422 type sequence L description binding site for residue FZ4 B 1001 source : AC2 5) chain B residue 426 type sequence H description binding site for residue FZ4 B 1001 source : AC2 6) chain B residue 429 type sequence L description binding site for residue FZ4 B 1001 source : AC2 7) chain B residue 693 type sequence R description binding site for residue FZ4 B 1001 source : AC2 8) chain B residue 546-566 type TRANSMEM sequence EYLACLVLAMALGWANMLYYT description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 9) chain B residue 590-610 type TRANSMEM sequence FLFVYIVFLLGFGVALASLIE description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 650-670 type TRANSMEM sequence YPILFLFLLITYVILTFVLLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 11) chain B residue 440-460 type TRANSMEM sequence MFFLSFCFYFFYNITLTLVSY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 488-508 type TRANSMEM sequence MFVLIWAMCISVKEGIAIFLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 524-544 type TRANSMEM sequence FVFFIQAVLVILSVFLYLFAY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 461-487 type TOPO_DOM sequence YRGWLQLLGR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 15) chain B residue 545 type TOPO_DOM sequence K description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 567-589 type TOPO_DOM sequence RGFQSMGMYSVMIQKVILHDVLK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 17) chain B residue 621-637 type INTRAMEM sequence SYGSFSDAVLELFKLTI description Pore-forming => ECO:0000255 source Swiss-Prot : SWS_FT_FI4

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