eF-site ID 6ot5-ABCD PDB Code 6ot5 Chain A, B, C, D click to enlarge Title Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution Classification TRANSPORT PROTEIN Compound Transient receptor potential cation channel subfamily V member 3,Transient receptor potential cation channel subfamily V member 3 Source (TRPV3_HUMAN) Sequence A:  XXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEELVE LLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNINP NTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNI AIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYF GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILH ALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDG LTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWA YGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLT LEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYY RGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFVFF IQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTR GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALAS LIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQN SKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKE SERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDD FRLCLRINEVKWTEWKTHVSFLN B:  XXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEELVE LLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNINP NTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNI AIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYF GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILH ALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDG LTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWA YGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLT LEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYY RGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFVFF IQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTR GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALAS LIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQN SKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKE SERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDD FRLCLRINEVKWTEWKTHVSFLN C:  XXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEELVE LLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNINP NTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNI AIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYF GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILH ALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDG LTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWA YGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLT LEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYY RGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFVFF IQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTR GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALAS LIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQN SKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKE SERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDD FRLCLRINEVKWTEWKTHVSFLN D:  XXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEELVE LLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNINP NTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNI AIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYF GETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILH ALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDG LTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWA YGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLT LEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYY RGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFVFF IQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTR GFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALAS LIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQN SKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKE SERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDD FRLCLRINEVKWTEWKTHVSFLN Description (1)  Transient receptor potential cation channel subfamily V member 3 Functional site 1) chain A residue 417 type sequence H description binding site for residue FZ4 A 1001 source : AC1 2) chain A residue 420 type sequence L description binding site for residue FZ4 A 1001 source : AC1 3) chain A residue 421 type sequence T description binding site for residue FZ4 A 1001 source : AC1 4) chain A residue 422 type sequence L description binding site for residue FZ4 A 1001 source : AC1 5) chain A residue 426 type sequence H description binding site for residue FZ4 A 1001 source : AC1 6) chain A residue 429 type sequence L description binding site for residue FZ4 A 1001 source : AC1 7) chain A residue 693 type sequence R description binding site for residue FZ4 A 1001 source : AC1 8) chain B residue 417 type sequence H description binding site for residue FZ4 B 1001 source : AC2 9) chain B residue 420 type sequence L description binding site for residue FZ4 B 1001 source : AC2 10) chain B residue 421 type sequence T description binding site for residue FZ4 B 1001 source : AC2 11) chain B residue 422 type sequence L description binding site for residue FZ4 B 1001 source : AC2 12) chain B residue 426 type sequence H description binding site for residue FZ4 B 1001 source : AC2 13) chain B residue 429 type sequence L description binding site for residue FZ4 B 1001 source : AC2 14) chain B residue 693 type sequence R description binding site for residue FZ4 B 1001 source : AC2 15) chain C residue 417 type sequence H description binding site for residue FZ4 C 1001 source : AC3 16) chain C residue 420 type sequence L description binding site for residue FZ4 C 1001 source : AC3 17) chain C residue 421 type sequence T description binding site for residue FZ4 C 1001 source : AC3 18) chain C residue 422 type sequence L description binding site for residue FZ4 C 1001 source : AC3 19) chain C residue 426 type sequence H description binding site for residue FZ4 C 1001 source : AC3 20) chain C residue 429 type sequence L description binding site for residue FZ4 C 1001 source : AC3 21) chain C residue 693 type sequence R description binding site for residue FZ4 C 1001 source : AC3 22) chain D residue 417 type sequence H description binding site for residue FZ4 D 1001 source : AC4 23) chain D residue 420 type sequence L description binding site for residue FZ4 D 1001 source : AC4 24) chain D residue 421 type sequence T description binding site for residue FZ4 D 1001 source : AC4 25) chain D residue 422 type sequence L description binding site for residue FZ4 D 1001 source : AC4 26) chain D residue 426 type sequence H description binding site for residue FZ4 D 1001 source : AC4 27) chain D residue 429 type sequence L description binding site for residue FZ4 D 1001 source : AC4 28) chain D residue 693 type sequence R description binding site for residue FZ4 D 1001 source : AC4 29) chain A residue 440-460 type TRANSMEM sequence MFFLSFCFYFFYNITLTLVSY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 30) chain B residue 546-566 type TRANSMEM sequence EYLACLVLAMALGWANMLYYT description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 31) chain B residue 590-610 type TRANSMEM sequence FLFVYIVFLLGFGVALASLIE description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 650-670 type TRANSMEM sequence YPILFLFLLITYVILTFVLLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 33) chain C residue 440-460 type TRANSMEM sequence MFFLSFCFYFFYNITLTLVSY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 34) chain C residue 488-508 type TRANSMEM sequence MFVLIWAMCISVKEGIAIFLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 35) chain C residue 524-544 type TRANSMEM sequence FVFFIQAVLVILSVFLYLFAY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 36) chain C residue 546-566 type TRANSMEM sequence EYLACLVLAMALGWANMLYYT description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 37) chain C residue 590-610 type TRANSMEM sequence FLFVYIVFLLGFGVALASLIE description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 38) chain C residue 650-670 type TRANSMEM sequence YPILFLFLLITYVILTFVLLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 39) chain D residue 440-460 type TRANSMEM sequence MFFLSFCFYFFYNITLTLVSY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 40) chain A residue 488-508 type TRANSMEM sequence MFVLIWAMCISVKEGIAIFLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 41) chain D residue 488-508 type TRANSMEM sequence MFVLIWAMCISVKEGIAIFLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 42) chain D residue 524-544 type TRANSMEM sequence FVFFIQAVLVILSVFLYLFAY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 43) chain D residue 546-566 type TRANSMEM sequence EYLACLVLAMALGWANMLYYT description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 44) chain D residue 590-610 type TRANSMEM sequence FLFVYIVFLLGFGVALASLIE description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 45) chain D residue 650-670 type TRANSMEM sequence YPILFLFLLITYVILTFVLLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 46) chain A residue 524-544 type TRANSMEM sequence FVFFIQAVLVILSVFLYLFAY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 546-566 type TRANSMEM sequence EYLACLVLAMALGWANMLYYT description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 48) chain A residue 590-610 type TRANSMEM sequence FLFVYIVFLLGFGVALASLIE description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 650-670 type TRANSMEM sequence YPILFLFLLITYVILTFVLLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 50) chain B residue 440-460 type TRANSMEM sequence MFFLSFCFYFFYNITLTLVSY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 51) chain B residue 488-508 type TRANSMEM sequence MFVLIWAMCISVKEGIAIFLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 52) chain B residue 524-544 type TRANSMEM sequence FVFFIQAVLVILSVFLYLFAY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 461-487 type TOPO_DOM sequence YRGWLQLLGR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 54) chain A residue 545 type TOPO_DOM sequence K description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 55) chain B residue 461-487 type TOPO_DOM sequence YRGWLQLLGR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 56) chain B residue 545 type TOPO_DOM sequence K description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 57) chain C residue 461-487 type TOPO_DOM sequence YRGWLQLLGR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 58) chain C residue 545 type TOPO_DOM sequence K description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 59) chain D residue 461-487 type TOPO_DOM sequence YRGWLQLLGR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 60) chain D residue 545 type TOPO_DOM sequence K description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 61) chain D residue 567-589 type TOPO_DOM sequence RGFQSMGMYSVMIQKVILHDVLK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 62) chain A residue 567-589 type TOPO_DOM sequence RGFQSMGMYSVMIQKVILHDVLK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 63) chain B residue 567-589 type TOPO_DOM sequence RGFQSMGMYSVMIQKVILHDVLK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 64) chain C residue 567-589 type TOPO_DOM sequence RGFQSMGMYSVMIQKVILHDVLK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 65) chain A residue 621-637 type INTRAMEM sequence SYGSFSDAVLELFKLTI description Pore-forming => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 66) chain B residue 621-637 type INTRAMEM sequence SYGSFSDAVLELFKLTI description Pore-forming => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 67) chain C residue 621-637 type INTRAMEM sequence SYGSFSDAVLELFKLTI description Pore-forming => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 68) chain D residue 621-637 type INTRAMEM sequence SYGSFSDAVLELFKLTI description Pore-forming => ECO:0000255 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links