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eF-site ID
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6ot2-A |
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PDB Code
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6ot2 |
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Chain
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A |
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click to enlarge
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Title
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Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution |
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Classification
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TRANSPORT PROTEIN |
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Compound
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Transient receptor potential cation channel subfamily V member 3 |
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Source
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(TRPV3_HUMAN) |
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Sequence
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A: |
XXXXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEEL
VELLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNI
NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTAL
NIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGF
YFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNI
LHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNN
DGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTD
WAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEM
LTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVS
YYRGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFV
FFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY
TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVAL
ASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ
QNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVS
KESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAE
DDFRLCLRINEVKWTEWKTHVSFLN
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Description
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Functional site
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1)
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chain |
A |
| residue |
440-460 |
| type |
TRANSMEM |
| sequence |
MFFLSFCFYFFYNITLTLVSY
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| description |
Helical => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
A |
| residue |
488-508 |
| type |
TRANSMEM |
| sequence |
MFVLIWAMCISVKEGIAIFLL
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| description |
Helical => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI1
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3)
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chain |
A |
| residue |
524-544 |
| type |
TRANSMEM |
| sequence |
FVFFIQAVLVILSVFLYLFAY
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| description |
Helical => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI1
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|
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4)
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chain |
A |
| residue |
546-566 |
| type |
TRANSMEM |
| sequence |
EYLACLVLAMALGWANMLYYT
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| description |
Helical => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI1
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|
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5)
|
chain |
A |
| residue |
590-610 |
| type |
TRANSMEM |
| sequence |
FLFVYIVFLLGFGVALASLIE
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| description |
Helical => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI1
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|
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6)
|
chain |
A |
| residue |
650-670 |
| type |
TRANSMEM |
| sequence |
YPILFLFLLITYVILTFVLLL
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| description |
Helical => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI1
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7)
|
chain |
A |
| residue |
461-487 |
| type |
TOPO_DOM |
| sequence |
YRGWLQLLGR
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| description |
Extracellular => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI2
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8)
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chain |
A |
| residue |
545 |
| type |
TOPO_DOM |
| sequence |
K
|
| description |
Extracellular => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI2
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9)
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chain |
A |
| residue |
567-589 |
| type |
TOPO_DOM |
| sequence |
RGFQSMGMYSVMIQKVILHDVLK
|
| description |
Cytoplasmic => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI3
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|
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10)
|
chain |
A |
| residue |
621-637 |
| type |
INTRAMEM |
| sequence |
SYGSFSDAVLELFKLTI
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| description |
Pore-forming => ECO:0000255
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| source |
Swiss-Prot : SWS_FT_FI4
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