eF-site ID 6ot2-ABCD PDB Code 6ot2 Chain A, B, C, D Title Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution Classification TRANSPORT PROTEIN Compound Transient receptor potential cation channel subfamily V member 3 Source (TRPV3_HUMAN) Sequence A:  XXXXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEEL VELLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNI NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTAL NIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGF YFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNI LHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNN DGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTD WAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEM LTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVS YYRGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFV FFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVAL ASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ QNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVS KESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAE DDFRLCLRINEVKWTEWKTHVSFLN B:  XXXXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEEL VELLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNI NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTAL NIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGF YFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNI LHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNN DGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTD WAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEM LTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVS YYRGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFV FFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVAL ASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ QNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVS KESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAE DDFRLCLRINEVKWTEWKTHVSFLN C:  XXXXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEEL VELLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNI NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTAL NIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGF YFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNI LHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNN DGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTD WAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEM LTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVS YYRGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFV FFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVAL ASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ QNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVS KESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAE DDFRLCLRINEVKWTEWKTHVSFLN D:  XXXXXXXXXXXXXXEEQRRKKRRLKKRIFAAVSEGCVEEL VELLVELQELCRRRVPDFLMHKLTASDTGATCLMKALLNI NPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTAL NIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGF YFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNI LHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNN DGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTD WAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEM LTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVS YYRGWLQLLGRMFVLIWAMCISVKEGIAIFLLSDAWFHFV FFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYY TRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVAL ASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQ QNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVS KESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAE DDFRLCLRINEVKWTEWKTHVSFLN Description Functional site 1) chain A residue 440-460 type TRANSMEM sequence MFFLSFCFYFFYNITLTLVSY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 546-566 type TRANSMEM sequence EYLACLVLAMALGWANMLYYT description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 3) chain B residue 590-610 type TRANSMEM sequence FLFVYIVFLLGFGVALASLIE description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 4) chain B residue 650-670 type TRANSMEM sequence YPILFLFLLITYVILTFVLLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 5) chain D residue 440-460 type TRANSMEM sequence MFFLSFCFYFFYNITLTLVSY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 6) chain D residue 488-508 type TRANSMEM sequence MFVLIWAMCISVKEGIAIFLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 7) chain D residue 524-544 type TRANSMEM sequence FVFFIQAVLVILSVFLYLFAY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 8) chain D residue 546-566 type TRANSMEM sequence EYLACLVLAMALGWANMLYYT description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 9) chain D residue 590-610 type TRANSMEM sequence FLFVYIVFLLGFGVALASLIE description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 10) chain D residue 650-670 type TRANSMEM sequence YPILFLFLLITYVILTFVLLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 11) chain C residue 440-460 type TRANSMEM sequence MFFLSFCFYFFYNITLTLVSY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 12) chain A residue 488-508 type TRANSMEM sequence MFVLIWAMCISVKEGIAIFLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 13) chain C residue 488-508 type TRANSMEM sequence MFVLIWAMCISVKEGIAIFLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 14) chain C residue 524-544 type TRANSMEM sequence FVFFIQAVLVILSVFLYLFAY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 15) chain C residue 546-566 type TRANSMEM sequence EYLACLVLAMALGWANMLYYT description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 16) chain C residue 590-610 type TRANSMEM sequence FLFVYIVFLLGFGVALASLIE description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 17) chain C residue 650-670 type TRANSMEM sequence YPILFLFLLITYVILTFVLLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 524-544 type TRANSMEM sequence FVFFIQAVLVILSVFLYLFAY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 546-566 type TRANSMEM sequence EYLACLVLAMALGWANMLYYT description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 590-610 type TRANSMEM sequence FLFVYIVFLLGFGVALASLIE description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 650-670 type TRANSMEM sequence YPILFLFLLITYVILTFVLLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 440-460 type TRANSMEM sequence MFFLSFCFYFFYNITLTLVSY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 488-508 type TRANSMEM sequence MFVLIWAMCISVKEGIAIFLL description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 524-544 type TRANSMEM sequence FVFFIQAVLVILSVFLYLFAY description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 461-487 type TOPO_DOM sequence YRGWLQLLGR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 545 type TOPO_DOM sequence K description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 461-487 type TOPO_DOM sequence YRGWLQLLGR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 28) chain B residue 545 type TOPO_DOM sequence K description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 29) chain D residue 461-487 type TOPO_DOM sequence YRGWLQLLGR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 30) chain D residue 545 type TOPO_DOM sequence K description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 31) chain C residue 461-487 type TOPO_DOM sequence YRGWLQLLGR description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 32) chain C residue 545 type TOPO_DOM sequence K description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 33) chain C residue 567-589 type TOPO_DOM sequence RGFQSMGMYSVMIQKVILHDVLK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 34) chain A residue 567-589 type TOPO_DOM sequence RGFQSMGMYSVMIQKVILHDVLK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 567-589 type TOPO_DOM sequence RGFQSMGMYSVMIQKVILHDVLK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 36) chain D residue 567-589 type TOPO_DOM sequence RGFQSMGMYSVMIQKVILHDVLK description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 621-637 type INTRAMEM sequence SYGSFSDAVLELFKLTI description Pore-forming => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 38) chain B residue 621-637 type INTRAMEM sequence SYGSFSDAVLELFKLTI description Pore-forming => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 39) chain D residue 621-637 type INTRAMEM sequence SYGSFSDAVLELFKLTI description Pore-forming => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 40) chain C residue 621-637 type INTRAMEM sequence SYGSFSDAVLELFKLTI description Pore-forming => ECO:0000255 source Swiss-Prot : SWS_FT_FI4

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