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eF-site ID
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6os9-ABCDLR |
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PDB Code
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6os9 |
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Chain
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A, B, C, D, L, R |
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click to enlarge
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Title
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human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state) |
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Classification
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SIGNALING PROTEIN |
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Compound
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Neurotensin receptor type 1 |
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Source
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(6OS9) |
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Sequence
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A: |
TLSAEDKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGE
SGKSTIVKQMKITGIVETHFTFKDLHFKMFDVGGQRSERK
KWIHCFEGVTAIIFCVALSDYDLVNRMHESMKLFDSICNN
KWFTDTSIILFLNKKDLFEEKIKKSPLTICYPEYAGSNTY
EEAAAYIQCQFEDLNKRKDTKEIYTHFTCATDTKNVQFVF
DAVTDVIIKNNLKDCGLF
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| B: |
ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGR
IQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIW
DSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICS
IYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSG
DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSG
ACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFA
TGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSG
RLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTD
DGMAVATGSWDSFLKIWN
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| C: |
IAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKED
PLLTPVPASENPF
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| D: |
VQLVESGGGLVQPGGSRKLSCSASGFAFSSFGMHWVRQAP
EKGLEWVAYISSGSGTIYYADTVKGRFTISRDDPKNTLFL
QMTSLRSEDTAMYYCVRSIYYYGSSPFDFWGQGTTLTVSS
DIVMTQATSSVPVTPGESVSISCRSSKSLLHSNGNTYLYW
FLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTAFTLTI
SRLEAEDVGVYYCMQHLEYPLTFGAGTKLEL
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| L: |
KKPYIL
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| R: |
PSSELDVNTDIYSKVLVTAVYLALFVVGTVGNTVTLFTLA
RKKSLQSLQSTVHYHLGSLALSDLLTLLLAMPVELYNFIW
VHHPWAFGDAGCRGYYFLRDACTYATALNVASLSVERYLA
ICHPFKAKTLMSRSRTKKFISAIWLASALLAVPMLFTMGE
QNRSADGQHAGGLVCTPTIHTATVKVVIQVNTFMSFIFPM
VVISVLNTIIANKLTVMVRQAAEQRVQALRHGVRVLRAVV
IAFVVCWLPYHVRRLMFCYISDEQWTPFLYDFYHYFYMVT
NALFYVSSTINPILYNLVSANFRHIF
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Description
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(1) |
Neurotensin receptor type 1, JMV449, Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, scFv16
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Functional site
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|
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1)
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chain |
A |
| residue |
269 |
| type |
MOD_RES |
| sequence |
N
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| description |
N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
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| source |
Swiss-Prot : SWS_FT_FI1
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2)
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chain |
R |
| residue |
260-313 |
| type |
MOD_RES |
| sequence |
ANKLTVMVRQAAEQRVQALRHGVRVLRAVVIAFV
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| description |
Cysteine methyl ester => ECO:0000250|UniProtKB:P63212
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| source |
Swiss-Prot : SWS_FT_FI2
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3)
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chain |
R |
| residue |
206-234 |
| type |
BINDING |
| sequence |
TMGEQNRSADGQHAGGLVCTPTIHTATVK
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| description |
BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
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| source |
Swiss-Prot : SWS_FT_FI4
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4)
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chain |
R |
| residue |
336-353 |
| type |
BINDING |
| sequence |
PFLYDFYHYFYMVTNALF
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| description |
BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
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| source |
Swiss-Prot : SWS_FT_FI4
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5)
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chain |
A |
| residue |
200 |
| type |
BINDING |
| sequence |
D
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| description |
BINDING => ECO:0000269|PubMed:21115486
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| source |
Swiss-Prot : SWS_FT_FI5
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6)
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chain |
A |
| residue |
326 |
| type |
BINDING |
| sequence |
A
|
| description |
BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q
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| source |
Swiss-Prot : SWS_FT_FI6
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7)
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chain |
A |
| residue |
204 |
| type |
MOD_RES |
| sequence |
Q
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| description |
Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
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| source |
Swiss-Prot : SWS_FT_FI8
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8)
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chain |
A |
| residue |
351 |
| type |
MOD_RES |
| sequence |
C
|
| description |
ADP-ribosylcysteine; by pertussis toxin => ECO:0000250
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| source |
Swiss-Prot : SWS_FT_FI9
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9)
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chain |
B |
| residue |
70-84 |
| type |
prosite |
| sequence |
LVSASQDGKLIIWDS
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| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
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| source |
prosite : PS00678
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10)
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chain |
B |
| residue |
157-171 |
| type |
prosite |
| sequence |
IVTSSGDTTCALWDI
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| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
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| source |
prosite : PS00678
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11)
|
chain |
B |
| residue |
285-299 |
| type |
prosite |
| sequence |
LLAGYDDFNCNVWDA
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| description |
WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS
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| source |
prosite : PS00678
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12)
|
chain |
R |
| residue |
154-170 |
| type |
prosite |
| sequence |
ATALNVASLSVERYLAI
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| description |
G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ATAlNVASLSVERYLaI
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| source |
prosite : PS00237
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