Title
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Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR |
Classification
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VIRAL PROTEIN/Immune System |
Compound
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RC1 variant of HIV-1 Env glycoprotein gp41 |
Source
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(6ORQ) |
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Sequence
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A: |
VSLGFLGAAGSTMGAASMTLTVQARNLLSHWGIKQLQARV
LAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLS
EIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDL
LALD
|
B: |
AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWA
THACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIIS
LWDQSLKPCVKLTPLCVTLQCTNYAPNLLSNMRGELKQCS
FNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTS
AITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPC
PSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITN
NAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYFG
DIIGDIRMAHCNVSKATWNETLGKVVKQLRKHFGNNTIIR
FAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNND
SIVLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGL
ILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIE
PLGVAPTRCKRRV
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C: |
VSLGFLGAAGSTMGAASMTLTVQARNLLSHWGIKQLQARV
LAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLS
EIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDL
LALD
|
D: |
EVQLQESGGDLVKPGGSLKLSCAASGFTFSRYGMSWVRQT
PDKRLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLY
LQMSSLKSEDTAMYYCARHGITTVGVAMDYWGQGTYSHVS
SA
|
E: |
IVMTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQ
QKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHP
VEEEDAATYYCQQSNEDPYTFGAGTKLELKR
|
F: |
VSLGFLGAAGSTMGAASMTLTVQARNLLSHWGIKQLQARV
LAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLS
EIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDL
LALD
|
G: |
AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWA
THACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIIS
LWDQSLKPCVKLTPLCVTLQCTNYAPNLLSNMRGELKQCS
FNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTS
AITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPC
PSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITN
NAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYFG
DIIGDIRMAHCNVSKATWNETLGKVVKQLRKHFGNNTIIR
FAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNND
SIVLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGL
ILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIE
PLGVAPTRCKRRV
|
H: |
EVQLQESGGDLVKPGGSLKLSCAASGFTFSRYGMSWVRQT
PDKRLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLY
LQMSSLKSEDTAMYYCARHGITTVGVAMDYWGQGTYSHVS
SA
|
I: |
AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWA
THACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIIS
LWDQSLKPCVKLTPLCVTLQCTNYAPNLLSNMRGELKQCS
FNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTS
AITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPC
PSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITN
NAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYFG
DIIGDIRMAHCNVSKATWNETLGKVVKQLRKHFGNNTIIR
FAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNND
SIVLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGL
ILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIE
PLGVAPTRCKRRV
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J: |
EVQLQESGGDLVKPGGSLKLSCAASGFTFSRYGMSWVRQT
PDKRLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLY
LQMSSLKSEDTAMYYCARHGITTVGVAMDYWGQGTYSHVS
SA
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K: |
IVMTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQ
QKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHP
VEEEDAATYYCQQSNEDPYTFGAGTKLELKR
|
L: |
IVMTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQ
QKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHP
VEEEDAATYYCQQSNEDPYTFGAGTKLELKR
|
|
Description
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(1) |
Envelope glycoprotein gp41, Envelope glycoprotein gp120, Ab275MUR antibody Fab heavy chain, Ab275MUR antibody Fab light chain
|