eF-site ID 6orq-ABCDEFGHIJKL PDB Code 6orq Chain A, B, C, D, E, F, G, H, I, J, K, L Title Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR Classification VIRAL PROTEIN/Immune System Compound RC1 variant of HIV-1 Env glycoprotein gp41 Source (6ORQ) Sequence A:  VSLGFLGAAGSTMGAASMTLTVQARNLLSHWGIKQLQARV LAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLS EIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDL LALD B:  AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWA THACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIIS LWDQSLKPCVKLTPLCVTLQCTNYAPNLLSNMRGELKQCS FNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTS AITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPC PSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITN NAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYFG DIIGDIRMAHCNVSKATWNETLGKVVKQLRKHFGNNTIIR FAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNND SIVLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGL ILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIE PLGVAPTRCKRRV C:  VSLGFLGAAGSTMGAASMTLTVQARNLLSHWGIKQLQARV LAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLS EIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDL LALD D:  EVQLQESGGDLVKPGGSLKLSCAASGFTFSRYGMSWVRQT PDKRLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLY LQMSSLKSEDTAMYYCARHGITTVGVAMDYWGQGTYSHVS SA E:  IVMTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQ QKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHP VEEEDAATYYCQQSNEDPYTFGAGTKLELKR F:  VSLGFLGAAGSTMGAASMTLTVQARNLLSHWGIKQLQARV LAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLS EIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDL LALD G:  AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWA THACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIIS LWDQSLKPCVKLTPLCVTLQCTNYAPNLLSNMRGELKQCS FNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTS AITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPC PSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITN NAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYFG DIIGDIRMAHCNVSKATWNETLGKVVKQLRKHFGNNTIIR FAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNND SIVLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGL ILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIE PLGVAPTRCKRRV H:  EVQLQESGGDLVKPGGSLKLSCAASGFTFSRYGMSWVRQT PDKRLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLY LQMSSLKSEDTAMYYCARHGITTVGVAMDYWGQGTYSHVS SA I:  AENLWVTVYYGVPVWKDAETTLFCASDAKAYETEKHNVWA THACVPTDPNPQEIHLENVTEEFNMWKNNMVEQMHEDIIS LWDQSLKPCVKLTPLCVTLQCTNYAPNLLSNMRGELKQCS FNMTTELRDKKQKVYSLFYRLDVVQINSNKEYRLINCNTS AITQACPKVSFEPIPIHYCAPAGFAILKCKDKKFNGTGPC PSVSTVQCTHGIKPVVSTQLLLNGSLAEEEVIIRSENITN NAKNILVQLNTPVQINCTRPNNNTVKSIRIGPGQAFYYFG DIIGDIRMAHCNVSKATWNETLGKVVKQLRKHFGNNTIIR FAQSSGGDLEVTTHSFNCGGEFFYCNTSGLFNSTWISNND SIVLPCRIKQIINMWQRIGQAMYAPPIQGVIRCVSNITGL ILTRDGGSTNSTTETFRPGGGDMRDNWRSELYKYKVVKIE PLGVAPTRCKRRV J:  EVQLQESGGDLVKPGGSLKLSCAASGFTFSRYGMSWVRQT PDKRLEWVATISSGGSYTYYPDSVKGRFTISRDNAKNTLY LQMSSLKSEDTAMYYCARHGITTVGVAMDYWGQGTYSHVS SA K:  IVMTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQ QKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHP VEEEDAATYYCQQSNEDPYTFGAGTKLELKR L:  IVMTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWYQ QKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHP VEEEDAATYYCQQSNEDPYTFGAGTKLELKR Description (1)  Envelope glycoprotein gp41, Envelope glycoprotein gp120, Ab275MUR antibody Fab heavy chain, Ab275MUR antibody Fab light chain Functional site 1) chain D residue 93-100 type prosite sequence ARHGITTV description THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. ARHGITTVGVA source prosite : PS00639

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