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Title
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Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074 |
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Classification
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VIRAL PROTEIN/Immune System |
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Compound
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RC1 variant of HIV-1 Env glycoprotein gp41 |
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Source
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(6ORN) |
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Sequence
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A: |
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQS
PGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSL
KLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMD
VWGKGTTVTVSSA
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| B: |
VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILL
IYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEA
DYYCHMWDSRSGFSWSFGGATRLTVLG
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| C: |
VSLGFLGAAGSTMGAASMTLTVQARNLLSHWGIKQLQARV
LAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLS
EIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDL
LALD
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| F: |
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQS
PGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSL
KLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMD
VWGKGTTVTVSSA
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| G: |
AENLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTP
QEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVK
LTPLCVTLQCTNYAPNLLSNMRGELKQCSFNMTTELRDKK
QKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSF
EPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHG
IKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNT
PVQINCTRPNNNTVKSIRIGPGQAFYYFGDIIGDIRMAHC
NVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEV
TTHSFNCGGEFFYCNTSGLFNSTWISNNDSIVLPCRIKQI
INMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNS
TTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKR
RV
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| I: |
VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILL
IYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEA
DYYCHMWDSRSGFSWSFGGATRLTVLG
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| J: |
VSLGFLGAAGSTMGAASMTLTVQARNLLSHWGIKQLQARV
LAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLS
EIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDL
LALD
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| K: |
AENLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTP
QEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVK
LTPLCVTLQCTNYAPNLLSNMRGELKQCSFNMTTELRDKK
QKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSF
EPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHG
IKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNT
PVQINCTRPNNNTVKSIRIGPGQAFYYFGDIIGDIRMAHC
NVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEV
TTHSFNCGGEFFYCNTSGLFNSTWISNNDSIVLPCRIKQI
INMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNS
TTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKR
RV
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| O: |
QVQLQESGPGLVKPSETLSVTCSVSGDSMNNYYWTWIRQS
PGKGLEWIGYISDRESATYNPSLNSRVVISRDTSKNQLSL
KLNSVTPADTAVYYCATARRGQRIYGVVSFGEFFYYYSMD
VWGKGTTVTVSSA
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| P: |
VRPLSVALGETARISCGRQALGSRAVQWYQHRPGQAPILL
IYNNQDRPSGIPERFSGTPDINFGTRATLTISGVEAGDEA
DYYCHMWDSRSGFSWSFGGATRLTVLG
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| Q: |
VSLGFLGAAGSTMGAASMTLTVQARNLLSHWGIKQLQARV
LAVEHYLRDQQLLGIWGCSGKLICCTNVPWNSSWSNRNLS
EIWDNMTWLQWDKEISNYTQIIYGLLEESQNQQEKNEQDL
LALD
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| R: |
AENLWVTVYYGVPVWKDAETTLFCASDHNVWATHACVPTP
QEIHLENVTEEFNMWKNNMVEQMHEDIISLWDQSLKPCVK
LTPLCVTLQCTNYAPNLLSNMRGELKQCSFNMTTELRDKK
QKVYSLFYRLDVVQINSNKEYRLINCNTSAITQACPKVSF
EPIPIHYCAPAGFAILKCKDKKFNGTGPCPSVSTVQCTHG
IKPVVSTQLLLNGSLAEEEVIIRSENITNNAKNILVQLNT
PVQINCTRPNNNTVKSIRIGPGQAFYYFGDIIGDIRMAHC
NVSKATWNETLGKVVKQLRKHFGNNTIIRFAQSSGGDLEV
TTHSFNCGGEFFYCNTSGLFNSTWISNNDSIVLPCRIKQI
INMWQRIGQAMYAPPIQGVIRCVSNITGLILTRDGGSTNS
TTETFRPGGGDMRDNWRSELYKYKVVKIEPLGVAPTRCKR
RV
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Description
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(1) |
Envelope glycoprotein gp41, Envelope glycoprotein gp120, 10-1074 Fab Heavy Chain,10-1074 Fab Light Chain
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