eF-site ID 6oqn-AB
PDB Code 6oqn
Chain A, B

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Title Crystal structure of Mcl1 with inhibitor 7
Classification APOPTOSIS
Compound Induced myeloid leukemia cell differentiation protein Mcl-1
Source (MCL1_HUMAN)
Sequence A:  EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKAL
ETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVM
IHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHV
B:  EDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKAL
ETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVM
IHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPL
AESITDVLVRTKRDWLVKQRGWDGFVEFFHV
Description


Functional site

1) chain A
residue 227
type
sequence A
description binding site for residue N0P A 401
source : AC1

2) chain A
residue 250
type
sequence M
description binding site for residue N0P A 401
source : AC1

3) chain A
residue 263
type
sequence R
description binding site for residue N0P A 401
source : AC1

4) chain A
residue 267
type
sequence L
description binding site for residue N0P A 401
source : AC1

5) chain A
residue 270
type
sequence F
description binding site for residue N0P A 401
source : AC1

6) chain A
residue 290
type
sequence L
description binding site for residue N0P A 401
source : AC1

7) chain B
residue 227
type
sequence A
description binding site for residue N0P B 401
source : AC2

8) chain B
residue 249
type
sequence V
description binding site for residue N0P B 401
source : AC2

9) chain B
residue 250
type
sequence M
description binding site for residue N0P B 401
source : AC2

10) chain B
residue 263
type
sequence R
description binding site for residue N0P B 401
source : AC2

11) chain B
residue 266
type
sequence T
description binding site for residue N0P B 401
source : AC2

12) chain B
residue 267
type
sequence L
description binding site for residue N0P B 401
source : AC2

13) chain B
residue 270
type
sequence F
description binding site for residue N0P B 401
source : AC2

14) chain B
residue 290
type
sequence L
description binding site for residue N0P B 401
source : AC2

15) chain A
residue 253-272
type prosite
sequence VFSDGVTNWGRIVTLISFGA
description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA
source prosite : PS01080

16) chain A
residue 305-316
type prosite
sequence WLVKQRGWDGFV
description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV
source prosite : PS01258

17) chain A
residue 209-223
type prosite
sequence ALETLRRVGDGVQRN
description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN
source prosite : PS01259

18) chain A
residue 194
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1

19) chain A
residue 197
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1

20) chain B
residue 194
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1

21) chain B
residue 197
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
source Swiss-Prot : SWS_FT_FI1


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