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eF-site ID
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6oq5-ADEF |
PDB Code
|
6oq5 |
Chain
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A, D, E, F |
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click to enlarge
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Title
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Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs |
Classification
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TOXIN |
Compound
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Toxin B |
Source
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(6OQ5) |
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Sequence
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A: |
SLVNRKQLEKMANVRFRVQEDEYVAILDALEEYHNMSENT
VVEKYLKLKDINSLTDTYIDTYKKSGRNKALKKFKEYLVI
EILELKNSNLTPVEKNLHFIWIGGQINDTAINYINQWKDV
NSDYNVNVFYDSNAFLINTLKKTIIESASNDTLESFRENL
NDPEFNHTAFFRKRMQIIYDKQQNFINYYKAQKEENPDLI
IDDIVKTYLSNEYSKDIDELNAYIEESLNKVTENSGNDVR
NFEEFKTGEVFNLYEQELVERWNLAGASDILRVAILKNIG
GVYLDVDMLPGIHPDLFKDINKPDSVKTAVDWEEMQLEAI
MKHKEYIPEYTSKHFDTLDEEVQSSFESVLASKSDKSEIF
LPLGDIEVSPLEVKIAFAKGSIINQALISAKDSYCSDLLI
KQIQNRYKILNDTLGPIISQGNDFNTTMNNFGESLGAIAN
EENISFIAKIGSYLRVGFYPEANTTITLSGPTIYAGAYKD
LLTFKEMSIDTSILSSELRNFEFPKVNISQATEQEKNSLW
QFNEERAKIQFEEYKKNYFEGALGEDDNLDFSQNTVTDKE
YLLEKISSSTKSSERGYVHYIVQLQGDKISYEAACNLFAK
NPYDSILFQKNIEDSEVAYYYNPTDSEIQEIDKYRIPDRI
SDRPKIKLTFIGHGKAEFNTDIFAGLDVDSLSSEIETAIG
LAKEDISPKSIEINLLGCNMFSYSVNVEETYPGKLLLRVK
DKVSELMPSMSQDSIIVSANQYEVRINSEGRRELLDHSGE
WINKEESIIKDISSKEYISFNPKENKIIVKSKNLPELSTL
LQEIRNNSNSSDIELEEKVMLAECEINVISNIETQVVEER
IEEAKSLTSDSINYIKNEFKLIESISDALCDLKQQNELED
SHFISFEDISETDEGFSIRFINKETGESIFVETEKTIFSE
YANHITEEISKIKGTIFDTVNGNLDTTHEVNTLNAAFFIQ
SLIEYNSSKESLSNLSVAMKVQVYAQLFSTGLNTITDAAK
VVELVSTALDETIDLLPTLSEGLPELSETSDPLLRQEIEA
KIGIMAVNLTTATTAIITSSLGIASGFSILLVPLAGISAG
IPSLVNNELVLRDKATKVVDYFKHVSLVETEGVFTLLDDK
VMMPQDDLVISEIDFNNNSIVLGKCEIWRMEGGSGHTVTD
DIDHFFSAPSITYREPHLSIYDVLEVQKEELDLSKDLMVL
PNAPNRVFAWETGWTPGLRSLENDGTKLLDRIRDNYEGEF
YWRYFAFIADALITTLKPRYEDTNIRINLDSNTRSFIVPI
ITTEYIREKLSYSFYGSGGTYALSLSQYNMGINIELSESD
VWIIDVDNVVRDVTIESDKIKKGDLIEGILSTLSIEENKI
ILNSHEINFSGEVNGSNGFVSLTFSILEGINAIIEVDLLS
KSYKLLISGELKILMLNSNHIQQKIDYIGFNSELQKNIPY
SFVDSEGKENGFINGSTKEGLFVSELPDVVLISKVYMDDS
KPSFGYYSNNLKDVKVITKDNVNILTGYYLKDDIKISLSL
TLQDEKTIKLNSVHLDESGVAEILKFMNRKGSTNTSDSLM
SFLESMNIKSIFVNFLQSNIKFILDANFIISGTTSIGQFE
FICDENNNIQPYFIKFNTLETNYTLYVGNRQNMIVEPNYD
LDDSGDISSTVINFSQKYLYGIDSCVNKVVISPNIYTDEI
NITPVYETNNTYPEVIVLDANYINEKINVNINDLSIRYVW
SNDGNDFILMSTSEENKVSQVKIRFVNVFKDKTLANKLSF
NFSDKQDVPVSEIILSFTPSYYEDGLIGYDLGLVSLYNEK
FYINNFGMMVSGLIYINDSLYYFKPPVNNLITGFVTVGDD
KYYFNPINGGAASIGETIIDDKNYYFNQSGVLQTGVFSTE
DGFKYFAPANTLDENLEGEAIDFTGKLIIDENIYYFEDNY
RGAVEWKELDGEMHYFSPETGKAFKGLNQIGDDKYYFNSD
GVMQKGFVSINDNKHYFDDSGVMKVGYTEIDGKHFYFAEN
GEMQIGVFNTEDGFKYFAHHNEDLGNEEGEEISYSGILNF
NNKIYYFDDSFTAVVGWKDLEDGSKYYFDEDTAEAYIGLS
LINDGQYYFNDDGIMQVGFVTINDKVFYFSDSGIIESGVQ
NIDDNYFYIDDNGIVQIGVFDTSDGYKYFAPANTVNDNIY
GQAVEYSGLVRVGEDVYYFGETYTIETGWIYDMENESDKY
YFDPETKKACKGINLIDDIKYYFDEKGIMRTGLISFENNN
YYFNENGEMQFGYINIEDKMFYFGEDGVMQIGVFNTPDGF
KYFAHQNTLDENFEGESINYTGWLDLDEKRYYFTDEYIAA
TGSVIIDGEEYYFDPDTAQLVISEHH
|
D: |
SQVQLVESGGGLVQPGGSLRLSCEASGFTLDYYGIGWFRQ
PPGKEREAVSYISASARTILYADSVKGRFTISRDNAKNAV
YLQMNSLKREDTAVYYCARRRFSASSVNRWLADDYDVWGR
GTQVAV
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E: |
LVESGGGLVQTGGSLRLSCASSGSIAGFETVTWSRQAPGK
SLQWVASMTKTNNEIYSDSVKGRFIISRDNAKNTVYLQMN
SLKPEDTGVYFCKGPELRGQGIQVTVS
|
F: |
QVQLVESGGGLVEAGGSLRLSCVVTGSSFSTSTMAWYRQP
PGKQREWVASFTSGGAIKYTDSVKGRFTMSRDNAKKMTYL
QMENLKPEDTAVYYCALHNAVSGSSWGRGTQVTVSS
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Description
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Functional site
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|
1)
|
chain |
A |
residue |
547 |
type |
|
sequence |
D
|
description |
binding site for residue ZN A 2801
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
654 |
type |
|
sequence |
H
|
description |
binding site for residue ZN A 2801
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
699 |
type |
|
sequence |
C
|
description |
binding site for residue ZN A 2801
|
source |
: AC1
|
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4)
|
chain |
A |
residue |
758 |
type |
|
sequence |
H
|
description |
binding site for residue ZN A 2801
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
286 |
type |
|
sequence |
D
|
description |
binding site for residue MG A 2802
|
source |
: AC2
|
|
6)
|
chain |
A |
residue |
288 |
type |
|
sequence |
D
|
description |
binding site for residue MG A 2802
|
source |
: AC2
|
|
7)
|
chain |
A |
residue |
516 |
type |
|
sequence |
E
|
description |
binding site for residue MG A 2802
|
source |
: AC2
|
|
8)
|
chain |
A |
residue |
520 |
type |
|
sequence |
L
|
description |
binding site for residue MG A 2802
|
source |
: AC2
|
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