eF-site ID 6oq5-ADEF
PDB Code 6oq5
Chain A, D, E, F

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Title Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs
Classification TOXIN
Compound Toxin B
Source (6OQ5)
Sequence A:  SLVNRKQLEKMANVRFRVQEDEYVAILDALEEYHNMSENT
VVEKYLKLKDINSLTDTYIDTYKKSGRNKALKKFKEYLVI
EILELKNSNLTPVEKNLHFIWIGGQINDTAINYINQWKDV
NSDYNVNVFYDSNAFLINTLKKTIIESASNDTLESFRENL
NDPEFNHTAFFRKRMQIIYDKQQNFINYYKAQKEENPDLI
IDDIVKTYLSNEYSKDIDELNAYIEESLNKVTENSGNDVR
NFEEFKTGEVFNLYEQELVERWNLAGASDILRVAILKNIG
GVYLDVDMLPGIHPDLFKDINKPDSVKTAVDWEEMQLEAI
MKHKEYIPEYTSKHFDTLDEEVQSSFESVLASKSDKSEIF
LPLGDIEVSPLEVKIAFAKGSIINQALISAKDSYCSDLLI
KQIQNRYKILNDTLGPIISQGNDFNTTMNNFGESLGAIAN
EENISFIAKIGSYLRVGFYPEANTTITLSGPTIYAGAYKD
LLTFKEMSIDTSILSSELRNFEFPKVNISQATEQEKNSLW
QFNEERAKIQFEEYKKNYFEGALGEDDNLDFSQNTVTDKE
YLLEKISSSTKSSERGYVHYIVQLQGDKISYEAACNLFAK
NPYDSILFQKNIEDSEVAYYYNPTDSEIQEIDKYRIPDRI
SDRPKIKLTFIGHGKAEFNTDIFAGLDVDSLSSEIETAIG
LAKEDISPKSIEINLLGCNMFSYSVNVEETYPGKLLLRVK
DKVSELMPSMSQDSIIVSANQYEVRINSEGRRELLDHSGE
WINKEESIIKDISSKEYISFNPKENKIIVKSKNLPELSTL
LQEIRNNSNSSDIELEEKVMLAECEINVISNIETQVVEER
IEEAKSLTSDSINYIKNEFKLIESISDALCDLKQQNELED
SHFISFEDISETDEGFSIRFINKETGESIFVETEKTIFSE
YANHITEEISKIKGTIFDTVNGNLDTTHEVNTLNAAFFIQ
SLIEYNSSKESLSNLSVAMKVQVYAQLFSTGLNTITDAAK
VVELVSTALDETIDLLPTLSEGLPELSETSDPLLRQEIEA
KIGIMAVNLTTATTAIITSSLGIASGFSILLVPLAGISAG
IPSLVNNELVLRDKATKVVDYFKHVSLVETEGVFTLLDDK
VMMPQDDLVISEIDFNNNSIVLGKCEIWRMEGGSGHTVTD
DIDHFFSAPSITYREPHLSIYDVLEVQKEELDLSKDLMVL
PNAPNRVFAWETGWTPGLRSLENDGTKLLDRIRDNYEGEF
YWRYFAFIADALITTLKPRYEDTNIRINLDSNTRSFIVPI
ITTEYIREKLSYSFYGSGGTYALSLSQYNMGINIELSESD
VWIIDVDNVVRDVTIESDKIKKGDLIEGILSTLSIEENKI
ILNSHEINFSGEVNGSNGFVSLTFSILEGINAIIEVDLLS
KSYKLLISGELKILMLNSNHIQQKIDYIGFNSELQKNIPY
SFVDSEGKENGFINGSTKEGLFVSELPDVVLISKVYMDDS
KPSFGYYSNNLKDVKVITKDNVNILTGYYLKDDIKISLSL
TLQDEKTIKLNSVHLDESGVAEILKFMNRKGSTNTSDSLM
SFLESMNIKSIFVNFLQSNIKFILDANFIISGTTSIGQFE
FICDENNNIQPYFIKFNTLETNYTLYVGNRQNMIVEPNYD
LDDSGDISSTVINFSQKYLYGIDSCVNKVVISPNIYTDEI
NITPVYETNNTYPEVIVLDANYINEKINVNINDLSIRYVW
SNDGNDFILMSTSEENKVSQVKIRFVNVFKDKTLANKLSF
NFSDKQDVPVSEIILSFTPSYYEDGLIGYDLGLVSLYNEK
FYINNFGMMVSGLIYINDSLYYFKPPVNNLITGFVTVGDD
KYYFNPINGGAASIGETIIDDKNYYFNQSGVLQTGVFSTE
DGFKYFAPANTLDENLEGEAIDFTGKLIIDENIYYFEDNY
RGAVEWKELDGEMHYFSPETGKAFKGLNQIGDDKYYFNSD
GVMQKGFVSINDNKHYFDDSGVMKVGYTEIDGKHFYFAEN
GEMQIGVFNTEDGFKYFAHHNEDLGNEEGEEISYSGILNF
NNKIYYFDDSFTAVVGWKDLEDGSKYYFDEDTAEAYIGLS
LINDGQYYFNDDGIMQVGFVTINDKVFYFSDSGIIESGVQ
NIDDNYFYIDDNGIVQIGVFDTSDGYKYFAPANTVNDNIY
GQAVEYSGLVRVGEDVYYFGETYTIETGWIYDMENESDKY
YFDPETKKACKGINLIDDIKYYFDEKGIMRTGLISFENNN
YYFNENGEMQFGYINIEDKMFYFGEDGVMQIGVFNTPDGF
KYFAHQNTLDENFEGESINYTGWLDLDEKRYYFTDEYIAA
TGSVIIDGEEYYFDPDTAQLVISEHH
D:  SQVQLVESGGGLVQPGGSLRLSCEASGFTLDYYGIGWFRQ
PPGKEREAVSYISASARTILYADSVKGRFTISRDNAKNAV
YLQMNSLKREDTAVYYCARRRFSASSVNRWLADDYDVWGR
GTQVAV
E:  LVESGGGLVQTGGSLRLSCASSGSIAGFETVTWSRQAPGK
SLQWVASMTKTNNEIYSDSVKGRFIISRDNAKNTVYLQMN
SLKPEDTGVYFCKGPELRGQGIQVTVS
F:  QVQLVESGGGLVEAGGSLRLSCVVTGSSFSTSTMAWYRQP
PGKQREWVASFTSGGAIKYTDSVKGRFTMSRDNAKKMTYL
QMENLKPEDTAVYYCALHNAVSGSSWGRGTQVTVSS
Description


Functional site

1) chain A
residue 547
type
sequence D
description binding site for residue ZN A 2801
source : AC1

2) chain A
residue 654
type
sequence H
description binding site for residue ZN A 2801
source : AC1

3) chain A
residue 699
type
sequence C
description binding site for residue ZN A 2801
source : AC1

4) chain A
residue 758
type
sequence H
description binding site for residue ZN A 2801
source : AC1

5) chain A
residue 286
type
sequence D
description binding site for residue MG A 2802
source : AC2

6) chain A
residue 288
type
sequence D
description binding site for residue MG A 2802
source : AC2

7) chain A
residue 516
type
sequence E
description binding site for residue MG A 2802
source : AC2

8) chain A
residue 520
type
sequence L
description binding site for residue MG A 2802
source : AC2


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