eF-site ID 6opw-AB PDB Code 6opw Chain A, B click to enlarge Title HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, V82F, I84V Mutant in complex with darunavir Classification HYDROLASE/HYDROLASE INHIBITOR Compound Protease NL4-3 Source (Q7ZCI0_9HIV1) Sequence A:  PQITLWKRPLVTVKIEGQLKEALLDTGADDTIFEEMNLPG RWKPIIIGGIGGFIKVRQYDQILIEICGHKVIGTVLVGPT PFNVIGRNLLTQIGCTLNF B:  PQITLWKRPLVTVKIEGQLKEALLDTGADDTIFEEMNLPG RWKPIIIGGIGGFIKVRQYDQILIEICGHKVIGTVLVGPT PFNVIGRNLLTQIGCTLNF Description Functional site 1) chain B residue 2 type sequence Q description binding site for residue SO4 B 101 source : AC1 2) chain B residue 40 type sequence G description binding site for residue SO4 B 101 source : AC1 3) chain A residue 25 type sequence D description binding site for residue 017 A 101 source : AC2 4) chain A residue 27 type sequence G description binding site for residue 017 A 101 source : AC2 5) chain A residue 29 type sequence D description binding site for residue 017 A 101 source : AC2 6) chain A residue 30 type sequence D description binding site for residue 017 A 101 source : AC2 7) chain A residue 48 type sequence G description binding site for residue 017 A 101 source : AC2 8) chain A residue 49 type sequence G description binding site for residue 017 A 101 source : AC2 9) chain A residue 50 type sequence I description binding site for residue 017 A 101 source : AC2 10) chain B residue 8 type sequence R description binding site for residue 017 A 101 source : AC2 11) chain B residue 25 type sequence D description binding site for residue 017 A 101 source : AC2 12) chain B residue 27 type sequence G description binding site for residue 017 A 101 source : AC2 13) chain B residue 28 type sequence A description binding site for residue 017 A 101 source : AC2 14) chain B residue 30 type sequence D description binding site for residue 017 A 101 source : AC2 15) chain B residue 48 type sequence G description binding site for residue 017 A 101 source : AC2 16) chain B residue 49 type sequence G description binding site for residue 017 A 101 source : AC2 17) chain B residue 50 type sequence I description binding site for residue 017 A 101 source : AC2 18) chain B residue 81 type sequence P description binding site for residue 017 A 101 source : AC2 19) chain B residue 22-33 type prosite sequence ALLDTGADDTIF description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTIF source prosite : PS00141 20) chain B residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 22) chain B residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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