eF-site ID 6opw-AB
PDB Code 6opw
Chain A, B

click to enlarge
Title HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, V82F, I84V Mutant in complex with darunavir
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Protease NL4-3
Source (Q7ZCI0_9HIV1)
Sequence A:  PQITLWKRPLVTVKIEGQLKEALLDTGADDTIFEEMNLPG
RWKPIIIGGIGGFIKVRQYDQILIEICGHKVIGTVLVGPT
PFNVIGRNLLTQIGCTLNF
B:  PQITLWKRPLVTVKIEGQLKEALLDTGADDTIFEEMNLPG
RWKPIIIGGIGGFIKVRQYDQILIEICGHKVIGTVLVGPT
PFNVIGRNLLTQIGCTLNF
Description


Functional site

1) chain B
residue 2
type
sequence Q
description binding site for residue SO4 B 101
source : AC1

2) chain B
residue 40
type
sequence G
description binding site for residue SO4 B 101
source : AC1

3) chain A
residue 25
type
sequence D
description binding site for residue 017 A 101
source : AC2

4) chain A
residue 27
type
sequence G
description binding site for residue 017 A 101
source : AC2

5) chain A
residue 29
type
sequence D
description binding site for residue 017 A 101
source : AC2

6) chain A
residue 30
type
sequence D
description binding site for residue 017 A 101
source : AC2

7) chain A
residue 48
type
sequence G
description binding site for residue 017 A 101
source : AC2

8) chain A
residue 49
type
sequence G
description binding site for residue 017 A 101
source : AC2

9) chain A
residue 50
type
sequence I
description binding site for residue 017 A 101
source : AC2

10) chain B
residue 8
type
sequence R
description binding site for residue 017 A 101
source : AC2

11) chain B
residue 25
type
sequence D
description binding site for residue 017 A 101
source : AC2

12) chain B
residue 27
type
sequence G
description binding site for residue 017 A 101
source : AC2

13) chain B
residue 28
type
sequence A
description binding site for residue 017 A 101
source : AC2

14) chain B
residue 30
type
sequence D
description binding site for residue 017 A 101
source : AC2

15) chain B
residue 48
type
sequence G
description binding site for residue 017 A 101
source : AC2

16) chain B
residue 49
type
sequence G
description binding site for residue 017 A 101
source : AC2

17) chain B
residue 50
type
sequence I
description binding site for residue 017 A 101
source : AC2

18) chain B
residue 81
type
sequence P
description binding site for residue 017 A 101
source : AC2

19) chain B
residue 22-33
type prosite
sequence ALLDTGADDTIF
description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTIF
source prosite : PS00141

20) chain B
residue 25
type ACT_SITE
sequence D
description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
source Swiss-Prot : SWS_FT_FI1

21) chain A
residue 25
type ACT_SITE
sequence D
description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
source Swiss-Prot : SWS_FT_FI1

22) chain B
residue 99
type SITE
sequence F
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

23) chain A
residue 99
type SITE
sequence F
description Cleavage; by viral protease => ECO:0000250
source Swiss-Prot : SWS_FT_FI2


Display surface

Download
Links