|
eF-site ID
|
6opw-A |
PDB Code
|
6opw |
Chain
|
A |
|
click to enlarge
|
|
Title
|
HIV-1 Protease NL4-3 I13V, G16E, V32I, L33F, K45I, M46I, A71V, V82F, I84V Mutant in complex with darunavir |
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
Compound
|
Protease NL4-3 |
Source
|
(Q7ZCI0_9HIV1) |
|
Sequence
|
A: |
PQITLWKRPLVTVKIEGQLKEALLDTGADDTIFEEMNLPG
RWKPIIIGGIGGFIKVRQYDQILIEICGHKVIGTVLVGPT
PFNVIGRNLLTQIGCTLNF
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
25 |
type |
|
sequence |
D
|
description |
binding site for residue 017 A 101
|
source |
: AC2
|
|
2)
|
chain |
A |
residue |
27 |
type |
|
sequence |
G
|
description |
binding site for residue 017 A 101
|
source |
: AC2
|
|
3)
|
chain |
A |
residue |
29 |
type |
|
sequence |
D
|
description |
binding site for residue 017 A 101
|
source |
: AC2
|
|
4)
|
chain |
A |
residue |
30 |
type |
|
sequence |
D
|
description |
binding site for residue 017 A 101
|
source |
: AC2
|
|
5)
|
chain |
A |
residue |
48 |
type |
|
sequence |
G
|
description |
binding site for residue 017 A 101
|
source |
: AC2
|
|
6)
|
chain |
A |
residue |
49 |
type |
|
sequence |
G
|
description |
binding site for residue 017 A 101
|
source |
: AC2
|
|
7)
|
chain |
A |
residue |
50 |
type |
|
sequence |
I
|
description |
binding site for residue 017 A 101
|
source |
: AC2
|
|
8)
|
chain |
A |
residue |
25 |
type |
ACT_SITE |
sequence |
D
|
description |
For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
9)
|
chain |
A |
residue |
99 |
type |
SITE |
sequence |
F
|
description |
Cleavage; by viral protease => ECO:0000250
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|