|
|
eF-site ID
|
6oov-B |
|
PDB Code
|
6oov |
|
Chain
|
B |
|
click to enlarge
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Title
|
Crystal structure of HMCES SRAP domain in complex with palindromic 3' overhang DNA |
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Classification
|
DNA BINDING PROTEIN/DNA |
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Compound
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Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein |
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Source
|
(6OOV) |
|
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Sequence
|
B: |
CGRTSCHLPRDVLTRACAYQDRRGQQRLPEWRDPDKYCPS
YNKSPQSNSPVLLSRLHFEKDADSSERIIAPMRWGLVPSW
FKESDPSKLQFNTTNCRSDTVMEKRSFKVPLGKGRRCVVL
ADGFYEWQRCGTNQRQPYFIYFPQIKVWDNWRLLTMAGIF
DCWEPPEGGDVLYSYTIITVDSCKGLSDIHHRMPAILDGE
EAVSKWLDFGEVSTQEALKLIHPTENITFHAVSSVVNNSR
NNTPECLAPV
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
2 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
Nucleophile => ECO:0000269|PubMed:31235913, ECO:0000305|PubMed:30554877
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
127 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
ACT_SITE => ECO:0000269|PubMed:37519246, ECO:0000269|PubMed:37950866
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
B |
| residue |
127 |
| type |
SITE |
| sequence |
E
|
| description |
Required for sensing abasic sites => ECO:0000250|UniProtKB:P76318
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
B |
| residue |
210 |
| type |
SITE |
| sequence |
H
|
| description |
Required to stabilize abasic sites => ECO:0000250|UniProtKB:P76318
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
5)
|
chain |
B |
| residue |
2 |
| type |
MOD_RES |
| sequence |
C
|
| description |
Thiazolidine linkage to a ring-opened DNA abasic site => ECO:0000269|PubMed:31235913
|
| source |
Swiss-Prot : SWS_FT_FI5
|
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|
|