eF-site ID 6oot-B PDB Code 6oot Chain B click to enlarge Title HIV-1 Protease NL4-3 L89V, L90M Mutant in complex with darunavir Classification hydrolase/hydrolase inhibitor Compound NL4-3 PROTEASE Source (Q3HWC9_9HIV1) Sequence B:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPG RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT PVNIIGRNVMTQIGCTLNF Description Functional site 1) chain B residue 8 type sequence R description binding site for residue SO4 A 101 source : AC1 2) chain B residue 25 type sequence D description binding site for residue 017 B 101 source : AC2 3) chain B residue 27 type sequence G description binding site for residue 017 B 101 source : AC2 4) chain B residue 28 type sequence A description binding site for residue 017 B 101 source : AC2 5) chain B residue 30 type sequence D description binding site for residue 017 B 101 source : AC2 6) chain B residue 32 type sequence V description binding site for residue 017 B 101 source : AC2 7) chain B residue 48 type sequence G description binding site for residue 017 B 101 source : AC2 8) chain B residue 49 type sequence G description binding site for residue 017 B 101 source : AC2 9) chain B residue 81 type sequence P description binding site for residue 017 B 101 source : AC2 10) chain B residue 82 type sequence V description binding site for residue 017 B 101 source : AC2 11) chain B residue 84 type sequence I description binding site for residue 017 B 101 source : AC2 12) chain B residue 87 type sequence R description binding site for residue SO4 B 102 source : AC3 13) chain B residue 88 type sequence N description binding site for residue SO4 B 102 source : AC3 14) chain B residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links