eF-site ID 6oot-A PDB Code 6oot Chain A click to enlarge Title HIV-1 Protease NL4-3 L89V, L90M Mutant in complex with darunavir Classification hydrolase/hydrolase inhibitor Compound NL4-3 PROTEASE Source (Q3HWC9_9HIV1) Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVLEEMNLPG RWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPT PVNIIGRNVMTQIGCTLNF Description Functional site 1) chain A residue 7 type sequence K description binding site for residue SO4 A 101 source : AC1 2) chain A residue 8 type sequence R description binding site for residue SO4 A 101 source : AC1 3) chain A residue 25 type sequence D description binding site for residue 017 B 101 source : AC2 4) chain A residue 27 type sequence G description binding site for residue 017 B 101 source : AC2 5) chain A residue 28 type sequence A description binding site for residue 017 B 101 source : AC2 6) chain A residue 29 type sequence D description binding site for residue 017 B 101 source : AC2 7) chain A residue 30 type sequence D description binding site for residue 017 B 101 source : AC2 8) chain A residue 48 type sequence G description binding site for residue 017 B 101 source : AC2 9) chain A residue 49 type sequence G description binding site for residue 017 B 101 source : AC2 10) chain A residue 50 type sequence I description binding site for residue 017 B 101 source : AC2 11) chain A residue 84 type sequence I description binding site for residue 017 B 101 source : AC2 12) chain A residue 6 type sequence W description binding site for residue SO4 B 102 source : AC3 13) chain A residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 22-33 type prosite sequence ALLDTGADDTVL description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVL source prosite : PS00141 15) chain A residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094 source Swiss-Prot : SWS_FT_FI1

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