eF-site ID 6okk-Ag PDB Code 6okk Chain A, g click to enlarge Title Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine, small subunit Classification ribosome/inhibitor Compound 18S ribosomal RNA Source ORGANISM_SCIENTIFIC: Plasmodium falciparum (isolate 3D7); Sequence A:  AACCUGGUUGAUCUUGCCAGUAGUCAUAUGCUUGUCUCAA AGAUUAAGCCAUGCAAGUGAAAGUAUAUAUAUAUAUAUGU AGAAACUGCGAACGGCUCAUUAAAACAGUUAUAGUCUACU UGACAUUUAUAAGGAUAACUACGGAAAAGCUGUAGCUAAU ACUUGCAUUAUCCUUUUGGAUAAGUAUUUGUUAGAAGGAA UUAUAACAAAGAAGUAACACGUAAAGUGUGUAUCAAUCGA GUUUCUGACCUAUCAGCUUUUGAUGUUAGGGUAUUGGCCU AACAUGGCUAUGACGGGUAACGGGGAAUUAGAGUUCGAUU CCGGAGAGGGAGCCUGAGAAAUAGCUACCACAUCUAAGGA AGGCAGCAGGCGCGUAAAUUACCCAAUUCUAAAGAAGAGA GGUAGUGACAAGAAAUAACAAUGCAAGGUUUGUAUUGGAA UGGUGGGAAUUUAAAACCUUCCCAGAGUAACAAUUGGAGG GCAAGUCUGGUGCCAGCAGCCGCGGUAAUUCCAGCUCCAA UAGCGUAUAUUAAAAUUGUUGCAGUUAAAACGCUCGUAGU UGAAUUUCAAAGAAUCAUUCUUUUUAAAAUCCGGAUUUGU UACUUUGAGUAAAUUAGAGUGUUCAAAGCAAACAGUUAAA GCAUUGUGUUUGAAUACUAUAGCAUGGAAUAACAAAAUUG AACAAGCUAAAAUUUUUUGUUCUUAUUUUGGCUUAGUUAC GAUUAAUAGGAGUAGCUUGGGGACAUUCGUAUUCAGAUGU CAGAGGUGAAAUUCUUAGAUUUUCUGGAGACGAACAACUG CGAAAGCAUUUGUCUAAAAUACUUCCAUUAAUCAAGAACG AAAGUUAAGGGAGUGAAGACGAUCAGAUACCGUCGUAAUC UUAACCAUAAACUAUGCCGACUAGGUGUUGGAUGAAGUGC UUCCUUCAGUACCUUAUGAGAAAUCAAAGUCUUUGGGUUC UGGGGCGAGUAUUCGCGCAAGCGAGAAAGUUAAAAGAAUU GACGGAAGGGCACCACCAGGCGUGGAGCUUGCGGCUUAAU UUGACUCAACACGGGGAAACUCACUAGUUUAAGACAUUGG AUGGUGAUGCAUGGCCGUUUUUAGUUCGUGAAUGAUUUGU CUGGUUAAUUCCGAUAACGAACGAGAUCUUAACCUGCUAA UUAGCGGCGAGUACACUGUACUUGCUGCUUCUUAGAGGAA CAUUGUGUGUCUAACACAAGGAAGUUUAAGGCAACAACAG GUCUGUGAUGUCCUUAGAUGAACUAGGCUGCACGCGUGCU ACACUGAUAUAUAUAACGAGUAAAAUAUGCUUGCAUACUU UUCCUCCGCCGAAAGGCGUAGGUAAUCUUUAUCAAUAUAU AUCGUGAUGGGGAUAGAUUAUUGCAAUUAUUAAUCUUGAA CGAGGAAUGCCUAGUAAGCAUGAUUCAUCAGAUUGUGCUG ACUACGUCCCUGCCCUUUGUACACACCGCCCGUCGCUCCU ACCGAUUGAAAGAUAUGAUGAAUUGUUUGGACAAGAAAAA UUUUUUCUGGAAAAACCGUAAAUCCUAUCUUUUAAAGGAA GGAGAAGUCGUAACAAGGUUUCCGUAGGUGAACCUGCGGA AGGAUCAU g:  GGGUAAUUGGCGCAGUUGGUUAGCGCGCGGGUCUCAUAAU CCCGAGGUCGUGAGUUCGAUCCUCACAUUACCCA Description (1)  ribosome Functional site 1) chain A residue 10 type sequence G description binding site for residue MG A 2101 source : AC1 2) chain A residue 1930 type sequence A description binding site for residue MG A 2101 source : AC1 3) chain A residue 16 type sequence G description binding site for residue MG A 2102 source : AC2 4) chain A residue 102 type sequence A description binding site for residue MG A 2103 source : AC3 5) chain A residue 367 type sequence C description binding site for residue MG A 2103 source : AC3 6) chain A residue 102 type sequence A description binding site for residue MG A 2104 source : AC4 7) chain A residue 103 type sequence U description binding site for residue MG A 2104 source : AC4 8) chain A residue 104 type sequence U description binding site for residue MG A 2104 source : AC4 9) chain A residue 366 type sequence A description binding site for residue MG A 2104 source : AC4 10) chain A residue 367 type sequence C description binding site for residue MG A 2104 source : AC4 11) chain A residue 49 type sequence C description binding site for residue MG A 2105 source : AC5 12) chain A residue 431 type sequence A description binding site for residue MG A 2105 source : AC5 13) chain A residue 452 type sequence A description binding site for residue MG A 2106 source : AC6 14) chain A residue 454 type sequence U description binding site for residue MG A 2106 source : AC6 15) chain A residue 60 type sequence A description binding site for residue MG A 2107 source : AC7 16) chain A residue 459 type sequence A description binding site for residue MG A 2107 source : AC7 17) chain A residue 87 type sequence A description binding site for residue MG A 2108 source : AC8 18) chain A residue 97 type sequence G description binding site for residue MG A 2109 source : AC9 19) chain A residue 408 type sequence U description binding site for residue MG A 2111 source : AD1 20) chain A residue 328 type sequence G description binding site for residue MG A 2112 source : AD2 21) chain A residue 343 type sequence G description binding site for residue MG A 2112 source : AD2 22) chain A residue 347 type sequence A description binding site for residue MG A 2112 source : AD2 23) chain A residue 42 type sequence G description binding site for residue MG A 2113 source : AD3 24) chain A residue 43 type sequence A description binding site for residue MG A 2113 source : AD3 25) chain A residue 100 type sequence U description binding site for residue MG A 2113 source : AD3 26) chain A residue 44 type sequence U description binding site for residue MG A 2114 source : AD4 27) chain A residue 47 type sequence A description binding site for residue MG A 2114 source : AD4 28) chain A residue 435 type sequence G description binding site for residue MG A 2115 source : AD5 29) chain A residue 383 type sequence G description binding site for residue MG A 2116 source : AD6 30) chain A residue 384 type sequence A description binding site for residue MG A 2116 source : AD6 31) chain A residue 385 type sequence U description binding site for residue MG A 2116 source : AD6 32) chain A residue 407 type sequence A description binding site for residue MG A 2117 source : AD7 33) chain A residue 408 type sequence U description binding site for residue MG A 2117 source : AD7 34) chain A residue 430 type sequence C description binding site for residue MG A 2118 source : AD8 35) chain A residue 432 type sequence G description binding site for residue MG A 2118 source : AD8 36) chain A residue 466 type sequence A description binding site for residue MG A 2119 source : AD9 37) chain A residue 467 type sequence G description binding site for residue MG A 2119 source : AD9 38) chain A residue 28 type sequence A description binding site for residue MG A 2120 source : AE1 39) chain A residue 35 type sequence U description binding site for residue MG A 2121 source : AE2 40) chain A residue 522 type sequence G description binding site for residue MG A 2121 source : AE2 41) chain A residue 537 type sequence C description binding site for residue MG A 2121 source : AE2 42) chain A residue 568 type sequence G description binding site for residue MG A 2123 source : AE3 43) chain A residue 577 type sequence A description binding site for residue MG A 2124 source : AE4 44) chain A residue 578 type sequence G description binding site for residue MG A 2124 source : AE4 45) chain A residue 611 type sequence A description binding site for residue MG A 2125 source : AE5 46) chain A residue 377 type sequence G description binding site for residue MG A 2126 source : AE6 47) chain A residue 612 type sequence A description binding site for residue MG A 2126 source : AE6 48) chain A residue 614 type sequence A description binding site for residue MG A 2126 source : AE6 49) chain A residue 621 type sequence C description binding site for residue MG A 2127 source : AE7 50) chain A residue 625 type sequence U description binding site for residue MG A 2128 source : AE8 51) chain A residue 626 type sequence A description binding site for residue MG A 2128 source : AE8 52) chain A residue 627 type sequence A description binding site for residue MG A 2128 source : AE8 53) chain A residue 628 type sequence A description binding site for residue MG A 2128 source : AE8 54) chain A residue 630 type sequence C description binding site for residue MG A 2129 source : AE9 55) chain A residue 629 type sequence A description binding site for residue MG A 2130 source : AF1 56) chain A residue 630 type sequence C description binding site for residue MG A 2130 source : AF1 57) chain A residue 632 type sequence C description binding site for residue MG A 2130 source : AF1 58) chain A residue 1100 type sequence U description binding site for residue MG A 2130 source : AF1 59) chain A residue 637 type sequence A description binding site for residue MG A 2131 source : AF2 60) chain A residue 638 type sequence G description binding site for residue MG A 2131 source : AF2 61) chain A residue 642 type sequence A description binding site for residue MG A 2132 source : AF3 62) chain A residue 643 type sequence A description binding site for residue MG A 2132 source : AF3 63) chain A residue 930 type sequence A description binding site for residue MG A 2133 source : AF4 64) chain A residue 931 type sequence A description binding site for residue MG A 2133 source : AF4 65) chain A residue 1007 type sequence G description binding site for residue MG A 2135 source : AF5 66) chain A residue 1059 type sequence U description binding site for residue MG A 2136 source : AF6 67) chain A residue 1060 type sequence G description binding site for residue MG A 2136 source : AF6 68) chain A residue 1080 type sequence G description binding site for residue MG A 2136 source : AF6 69) chain A residue 1081 type sequence U description binding site for residue MG A 2137 source : AF7 70) chain A residue 1054 type sequence G description binding site for residue MG A 2138 source : AF8 71) chain A residue 964 type sequence G description binding site for residue MG A 2139 source : AF9 72) chain A residue 965 type sequence U description binding site for residue MG A 2139 source : AF9 73) chain A residue 983 type sequence G description binding site for residue MG A 2139 source : AF9 74) chain A residue 984 type sequence A description binding site for residue MG A 2139 source : AF9 75) chain A residue 986 type sequence U description binding site for residue MG A 2139 source : AF9 76) chain A residue 997 type sequence G description binding site for residue MG A 2140 source : AG1 77) chain A residue 998 type sequence A description binding site for residue MG A 2140 source : AG1 78) chain A residue 945 type sequence G description binding site for residue MG A 2141 source : AG2 79) chain A residue 1011 type sequence G description binding site for residue MG A 2142 source : AG3 80) chain A residue 1047 type sequence A description binding site for residue MG A 2143 source : AG4 81) chain A residue 1037 type sequence U description binding site for residue MG A 2144 source : AG5 82) chain A residue 1094 type sequence A description binding site for residue MG A 2145 source : AG6 83) chain A residue 1210 type sequence G description binding site for residue MG A 2146 source : AG7 84) chain A residue 1211 type sequence G description binding site for residue MG A 2146 source : AG7 85) chain A residue 1261 type sequence A description binding site for residue MG A 2147 source : AG8 86) chain A residue 1876 type sequence G description binding site for residue MG A 2147 source : AG8 87) chain A residue 1926 type sequence G description binding site for residue MG A 2148 source : AG9 88) chain A residue 1927 type sequence U description binding site for residue MG A 2148 source : AG9 89) chain A residue 2085 type sequence G description binding site for residue MG A 2148 source : AG9 90) chain A residue 2055 type sequence A description binding site for residue MG A 2149 source : AH1 91) chain A residue 2059 type sequence G description binding site for residue MG A 2149 source : AH1 92) chain A residue 2060 type sequence G description binding site for residue MG A 2149 source : AH1 93) chain A residue 2062 type sequence U description binding site for residue MG A 2149 source : AH1 94) chain A residue 2063 type sequence U description binding site for residue MG A 2149 source : AH1 95) chain A residue 2062 type sequence U description binding site for residue MG A 2150 source : AH2 96) chain A residue 2053 type sequence U description binding site for residue MG A 2151 source : AH3 97) chain A residue 2054 type sequence A description binding site for residue MG A 2151 source : AH3 98) chain A residue 2055 type sequence A description binding site for residue MG A 2151 source : AH3 99) chain A residue 2059 type sequence G description binding site for residue MG A 2151 source : AH3 100) chain A residue 2060 type sequence G description binding site for residue MG A 2151 source : AH3 101) chain A residue 20 type sequence G description binding site for residue MG A 2152 source : AH4 102) chain A residue 21 type sequence U description binding site for residue MG A 2152 source : AH4 103) chain A residue 521 type sequence G description binding site for residue MG A 2153 source : AH5 104) chain A residue 1405 type sequence U description binding site for residue MG A 2154 source : AH6 105) chain A residue 1406 type sequence G description binding site for residue MG A 2154 source : AH6 106) chain A residue 169 type sequence A description binding site for residue MG A 2155 source : AH7 107) chain A residue 170 type sequence C description binding site for residue MG A 2155 source : AH7 108) chain A residue 394 type sequence G description binding site for residue MG A 2156 source : AH8 109) chain A residue 408 type sequence U description binding site for residue MG A 2156 source : AH8 110) chain A residue 559 type sequence G description binding site for residue MG A 2157 source : AH9 111) chain A residue 560 type sequence G description binding site for residue MG A 2157 source : AH9 112) chain A residue 561 type sequence C description binding site for residue MG A 2157 source : AH9 113) chain A residue 562 type sequence A description binding site for residue MG A 2157 source : AH9 114) chain A residue 563 type sequence A description binding site for residue MG A 2157 source : AH9 115) chain A residue 1062 type sequence A description binding site for residue MG A 2158 source : AI1 116) chain A residue 1074 type sequence A description binding site for residue MG A 2158 source : AI1 117) chain A residue 1063 type sequence G description binding site for residue MG A 2159 source : AI2 118) chain A residue 1074 type sequence A description binding site for residue MG A 2159 source : AI2 119) chain A residue 1084 type sequence U description binding site for residue MG A 2160 source : AI3 120) chain A residue 1432 type sequence G description binding site for residue MG A 2161 source : AI4 121) chain A residue 1430 type sequence G description binding site for residue MG A 2162 source : AI5 122) chain A residue 1432 type sequence G description binding site for residue MG A 2162 source : AI5 123) chain A residue 1374 type sequence G description binding site for residue MG A 2163 source : AI6 124) chain A residue 1375 type sequence C description binding site for residue MG A 2163 source : AI6 125) chain A residue 1674 type sequence G description binding site for residue MG A 2163 source : AI6 126) chain A residue 1675 type sequence G description binding site for residue MG A 2163 source : AI6 127) chain A residue 1305 type sequence A description binding site for residue MG A 2164 source : AI7 128) chain A residue 1306 type sequence C description binding site for residue MG A 2164 source : AI7 129) chain A residue 1307 type sequence U description binding site for residue MG A 2164 source : AI7 130) chain A residue 1701 type sequence G description binding site for residue MG A 2164 source : AI7 131) chain A residue 1303 type sequence A description binding site for residue MG A 2165 source : AI8 132) chain A residue 1304 type sequence A description binding site for residue MG A 2165 source : AI8 133) chain A residue 1896 type sequence C description binding site for residue MG A 2165 source : AI8 134) chain A residue 1703 type sequence U description binding site for residue MG A 2166 source : AI9 135) chain A residue 1302 type sequence G description binding site for residue MG A 2167 source : AJ1 136) chain A residue 973 type sequence G description binding site for residue 34G P 201 source : AJ2 137) chain A residue 1068 type sequence U description binding site for residue 34G P 201 source : AJ2 138) chain A residue 1075 type sequence C description binding site for residue 34G P 201 source : AJ2 139) chain A residue 1076 type sequence C description binding site for residue 34G P 201 source : AJ2 140) chain A residue 2060 type sequence G description binding site for residue 34G P 201 source : AJ2 141) chain A residue 2061 type sequence U description binding site for residue 34G P 201 source : AJ2

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