eF-site ID 6ojs-D PDB Code 6ojs Chain D click to enlarge Title Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, MTX and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Bifunctional dihydrofolate reductase-thymidylate synthase Source (A0A0S4TER9_CRYHO) Sequence D:  EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNN KCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQD EADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDA LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQT FCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMG NRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAY RENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFE ELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHR EENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIE TLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTND NCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEP GELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKV ENIEDFKWEDIELIGYYPYPTIKMDMAV Description Functional site 1) chain D residue 10 type sequence V description binding site for residue NDP D 601 source : AD4 2) chain D residue 11 type sequence A description binding site for residue NDP D 601 source : AD4 3) chain D residue 19 type sequence I description binding site for residue NDP D 601 source : AD4 4) chain D residue 20 type sequence G description binding site for residue NDP D 601 source : AD4 5) chain D residue 23 type sequence G description binding site for residue NDP D 601 source : AD4 6) chain D residue 24 type sequence Q description binding site for residue NDP D 601 source : AD4 7) chain D residue 55 type sequence G description binding site for residue NDP D 601 source : AD4 8) chain D residue 56 type sequence R description binding site for residue NDP D 601 source : AD4 9) chain D residue 57 type sequence K description binding site for residue NDP D 601 source : AD4 10) chain D residue 58 type sequence T description binding site for residue NDP D 601 source : AD4 11) chain D residue 75 type sequence I description binding site for residue NDP D 601 source : AD4 12) chain D residue 76 type sequence S description binding site for residue NDP D 601 source : AD4 13) chain D residue 77 type sequence S description binding site for residue NDP D 601 source : AD4 14) chain D residue 78 type sequence S description binding site for residue NDP D 601 source : AD4 15) chain D residue 92 type sequence R description binding site for residue NDP D 601 source : AD4 16) chain D residue 113 type sequence C description binding site for residue NDP D 601 source : AD4 17) chain D residue 114 type sequence G description binding site for residue NDP D 601 source : AD4 18) chain D residue 115 type sequence G description binding site for residue NDP D 601 source : AD4 19) chain D residue 116 type sequence E description binding site for residue NDP D 601 source : AD4 20) chain D residue 117 type sequence S description binding site for residue NDP D 601 source : AD4 21) chain D residue 119 type sequence Y description binding site for residue NDP D 601 source : AD4 22) chain D residue 145 type sequence T description binding site for residue NDP D 601 source : AD4 23) chain D residue 257 type sequence R description binding site for residue UFP D 602 source : AD5 24) chain D residue 382 type sequence R description binding site for residue UFP D 602 source : AD5 25) chain D residue 383 type sequence R description binding site for residue UFP D 602 source : AD5 26) chain D residue 399 type sequence L description binding site for residue UFP D 602 source : AD5 27) chain D residue 402 type sequence C description binding site for residue UFP D 602 source : AD5 28) chain D residue 403 type sequence H description binding site for residue UFP D 602 source : AD5 29) chain D residue 422 type sequence Q description binding site for residue UFP D 602 source : AD5 30) chain D residue 423 type sequence R description binding site for residue UFP D 602 source : AD5 31) chain D residue 424 type sequence S description binding site for residue UFP D 602 source : AD5 32) chain D residue 425 type sequence C description binding site for residue UFP D 602 source : AD5 33) chain D residue 426 type sequence D description binding site for residue UFP D 602 source : AD5 34) chain D residue 430 type sequence G description binding site for residue UFP D 602 source : AD5 35) chain D residue 434 type sequence N description binding site for residue UFP D 602 source : AD5 36) chain D residue 464 type sequence H description binding site for residue UFP D 602 source : AD5 37) chain D residue 466 type sequence Y description binding site for residue UFP D 602 source : AD5 38) chain D residue 284 type sequence K description binding site for residue D96 D 603 source : AD6 39) chain D residue 287 type sequence A description binding site for residue D96 D 603 source : AD6 40) chain D residue 315 type sequence I description binding site for residue D96 D 603 source : AD6 41) chain D residue 319 type sequence N description binding site for residue D96 D 603 source : AD6 42) chain D residue 426 type sequence D description binding site for residue D96 D 603 source : AD6 43) chain D residue 429 type sequence L description binding site for residue D96 D 603 source : AD6 44) chain D residue 430 type sequence G description binding site for residue D96 D 603 source : AD6 45) chain D residue 433 type sequence F description binding site for residue D96 D 603 source : AD6 46) chain D residue 520 type sequence A description binding site for residue D96 D 603 source : AD6 47) chain D residue 9 type sequence V description binding site for residue MTX D 604 source : AD7 48) chain D residue 10 type sequence V description binding site for residue MTX D 604 source : AD7 49) chain D residue 11 type sequence A description binding site for residue MTX D 604 source : AD7 50) chain D residue 25 type sequence L description binding site for residue MTX D 604 source : AD7 51) chain D residue 32 type sequence D description binding site for residue MTX D 604 source : AD7 52) chain D residue 33 type sequence L description binding site for residue MTX D 604 source : AD7 53) chain D residue 36 type sequence F description binding site for residue MTX D 604 source : AD7 54) chain D residue 37 type sequence S description binding site for residue MTX D 604 source : AD7 55) chain D residue 58 type sequence T description binding site for residue MTX D 604 source : AD7 56) chain D residue 62 type sequence I description binding site for residue MTX D 604 source : AD7 57) chain D residue 67 type sequence L description binding site for residue MTX D 604 source : AD7 58) chain D residue 70 type sequence R description binding site for residue MTX D 604 source : AD7 59) chain D residue 113 type sequence C description binding site for residue MTX D 604 source : AD7 60) chain D residue 119 type sequence Y description binding site for residue MTX D 604 source : AD7 61) chain D residue 134 type sequence T description binding site for residue MTX D 604 source : AD7

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