eF-site ID 6ojs-ABCE PDB Code 6ojs Chain A, B, C, E click to enlarge Title Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, MTX and 2-amino-4-oxo-4,7-dihydro-pyrrolo[2,3-d]pyrimidine-methyl-phenyl-D-glutamic acid Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Bifunctional dihydrofolate reductase-thymidylate synthase Source (A0A0S4TER9_CRYHO) Sequence A:  EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNN KCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQD EADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDA LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQT FCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMG NRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAY RENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFE ELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHR EENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIE TLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTND NCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEP GELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKV ENIEDFKWEDIELIGYYPYPTIKMDMAV B:  EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNN KCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQD EADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDA LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQT FCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMG NRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAY RENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFE ELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHR EENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIE TLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTND NCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEP GELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKV ENIEDFKWEDIELIGYYPYPTIKMDMAV C:  EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNN KCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQD EADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDA LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQT FCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMG NRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAY RENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFE ELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHR EENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIE TLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTND NCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEP GELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKV ENIEDFKWEDIELIGYYPYPTIKMDMAV E:  EKNVSIVVAASVLSSGIGINGQLPWSISEDLKFFSKITNN KCDSNKKNALIMGRKTWDSIGRRPLKNRIIVVISSSLPQD EADPNVVVFRNLEDSIENLMNDDSIENIFVCGGESIYRDA LKDNFVDRIYLTRVALEDIEFDTYFPEIPETFLPVYMSQT FCTKNISYDFMIFEKQEKKLKSIDDTVDLLGEIFGIRKMG NRHKFPKEEIYNTPSIRFGREHYEFQYLDLLSRVLENGAY RENRTGISTYSIFGQMMRFDMRESFPLLTTKKVAIRSIFE ELIWFIKGDTNGNHLIEKKVYIWSGNGSKEYLERIGLGHR EENDLGPIYGFQWRHYNGEYKTMHDDYTGVGVDQLAKLIE TLKNNPKDRRHILTAWNPSALSQMALPPCHVLSQYYVTND NCLSCNLYQRSCDLGLGSPFNIASYAILTMMLAQVCGYEP GELAIFIGDAHIYENHLTQLKEQLSRTPRPFPQLKFKRKV ENIEDFKWEDIELIGYYPYPTIKMDMAV Description Functional site 1) chain A residue 11 type sequence A description binding site for residue NDP A 601 source : AC1 2) chain A residue 19 type sequence I description binding site for residue NDP A 601 source : AC1 3) chain A residue 20 type sequence G description binding site for residue NDP A 601 source : AC1 4) chain A residue 23 type sequence G description binding site for residue NDP A 601 source : AC1 5) chain A residue 24 type sequence Q description binding site for residue NDP A 601 source : AC1 6) chain A residue 25 type sequence L description binding site for residue NDP A 601 source : AC1 7) chain A residue 55 type sequence G description binding site for residue NDP A 601 source : AC1 8) chain A residue 56 type sequence R description binding site for residue NDP A 601 source : AC1 9) chain A residue 57 type sequence K description binding site for residue NDP A 601 source : AC1 10) chain A residue 58 type sequence T description binding site for residue NDP A 601 source : AC1 11) chain A residue 75 type sequence I description binding site for residue NDP A 601 source : AC1 12) chain A residue 76 type sequence S description binding site for residue NDP A 601 source : AC1 13) chain A residue 77 type sequence S description binding site for residue NDP A 601 source : AC1 14) chain A residue 78 type sequence S description binding site for residue NDP A 601 source : AC1 15) chain A residue 92 type sequence R description binding site for residue NDP A 601 source : AC1 16) chain A residue 113 type sequence C description binding site for residue NDP A 601 source : AC1 17) chain A residue 114 type sequence G description binding site for residue NDP A 601 source : AC1 18) chain A residue 115 type sequence G description binding site for residue NDP A 601 source : AC1 19) chain A residue 116 type sequence E description binding site for residue NDP A 601 source : AC1 20) chain A residue 117 type sequence S description binding site for residue NDP A 601 source : AC1 21) chain A residue 121 type sequence D description binding site for residue NDP A 601 source : AC1 22) chain A residue 145 type sequence T description binding site for residue NDP A 601 source : AC1 23) chain A residue 257 type sequence R description binding site for residue UFP A 602 source : AC2 24) chain A residue 316 type sequence W description binding site for residue UFP A 602 source : AC2 25) chain A residue 399 type sequence L description binding site for residue UFP A 602 source : AC2 26) chain A residue 402 type sequence C description binding site for residue UFP A 602 source : AC2 27) chain A residue 403 type sequence H description binding site for residue UFP A 602 source : AC2 28) chain A residue 422 type sequence Q description binding site for residue UFP A 602 source : AC2 29) chain A residue 423 type sequence R description binding site for residue UFP A 602 source : AC2 30) chain A residue 424 type sequence S description binding site for residue UFP A 602 source : AC2 31) chain A residue 425 type sequence C description binding site for residue UFP A 602 source : AC2 32) chain A residue 426 type sequence D description binding site for residue UFP A 602 source : AC2 33) chain A residue 430 type sequence G description binding site for residue UFP A 602 source : AC2 34) chain A residue 434 type sequence N description binding site for residue UFP A 602 source : AC2 35) chain A residue 464 type sequence H description binding site for residue UFP A 602 source : AC2 36) chain A residue 466 type sequence Y description binding site for residue UFP A 602 source : AC2 37) chain C residue 382 type sequence R description binding site for residue UFP A 602 source : AC2 38) chain C residue 383 type sequence R description binding site for residue UFP A 602 source : AC2 39) chain A residue 284 type sequence K description binding site for residue D96 A 603 source : AC3 40) chain A residue 287 type sequence A description binding site for residue D96 A 603 source : AC3 41) chain A residue 315 type sequence I description binding site for residue D96 A 603 source : AC3 42) chain A residue 319 type sequence N description binding site for residue D96 A 603 source : AC3 43) chain A residue 426 type sequence D description binding site for residue D96 A 603 source : AC3 44) chain A residue 429 type sequence L description binding site for residue D96 A 603 source : AC3 45) chain A residue 430 type sequence G description binding site for residue D96 A 603 source : AC3 46) chain A residue 433 type sequence F description binding site for residue D96 A 603 source : AC3 47) chain A residue 515 type sequence I description binding site for residue D96 A 603 source : AC3 48) chain A residue 519 type sequence M description binding site for residue D96 A 603 source : AC3 49) chain A residue 520 type sequence A description binding site for residue D96 A 603 source : AC3 50) chain A residue 9 type sequence V description binding site for residue MTX A 604 source : AC4 51) chain A residue 10 type sequence V description binding site for residue MTX A 604 source : AC4 52) chain A residue 11 type sequence A description binding site for residue MTX A 604 source : AC4 53) chain A residue 25 type sequence L description binding site for residue MTX A 604 source : AC4 54) chain A residue 32 type sequence D description binding site for residue MTX A 604 source : AC4 55) chain A residue 33 type sequence L description binding site for residue MTX A 604 source : AC4 56) chain A residue 36 type sequence F description binding site for residue MTX A 604 source : AC4 57) chain A residue 37 type sequence S description binding site for residue MTX A 604 source : AC4 58) chain A residue 58 type sequence T description binding site for residue MTX A 604 source : AC4 59) chain A residue 62 type sequence I description binding site for residue MTX A 604 source : AC4 60) chain A residue 67 type sequence L description binding site for residue MTX A 604 source : AC4 61) chain A residue 70 type sequence R description binding site for residue MTX A 604 source : AC4 62) chain A residue 113 type sequence C description binding site for residue MTX A 604 source : AC4 63) chain A residue 119 type sequence Y description binding site for residue MTX A 604 source : AC4 64) chain A residue 134 type sequence T description binding site for residue MTX A 604 source : AC4 65) chain B residue 11 type sequence A description binding site for residue NDP B 601 source : AC5 66) chain B residue 19 type sequence I description binding site for residue NDP B 601 source : AC5 67) chain B residue 20 type sequence G description binding site for residue NDP B 601 source : AC5 68) chain B residue 21 type sequence I description binding site for residue NDP B 601 source : AC5 69) chain B residue 23 type sequence G description binding site for residue NDP B 601 source : AC5 70) chain B residue 24 type sequence Q description binding site for residue NDP B 601 source : AC5 71) chain B residue 25 type sequence L description binding site for residue NDP B 601 source : AC5 72) chain B residue 55 type sequence G description binding site for residue NDP B 601 source : AC5 73) chain B residue 56 type sequence R description binding site for residue NDP B 601 source : AC5 74) chain B residue 57 type sequence K description binding site for residue NDP B 601 source : AC5 75) chain B residue 58 type sequence T description binding site for residue NDP B 601 source : AC5 76) chain B residue 75 type sequence I description binding site for residue NDP B 601 source : AC5 77) chain B residue 76 type sequence S description binding site for residue NDP B 601 source : AC5 78) chain B residue 77 type sequence S description binding site for residue NDP B 601 source : AC5 79) chain B residue 78 type sequence S description binding site for residue NDP B 601 source : AC5 80) chain B residue 92 type sequence R description binding site for residue NDP B 601 source : AC5 81) chain B residue 113 type sequence C description binding site for residue NDP B 601 source : AC5 82) chain B residue 114 type sequence G description binding site for residue NDP B 601 source : AC5 83) chain B residue 115 type sequence G description binding site for residue NDP B 601 source : AC5 84) chain B residue 116 type sequence E description binding site for residue NDP B 601 source : AC5 85) chain B residue 117 type sequence S description binding site for residue NDP B 601 source : AC5 86) chain B residue 119 type sequence Y description binding site for residue NDP B 601 source : AC5 87) chain B residue 121 type sequence D description binding site for residue NDP B 601 source : AC5 88) chain B residue 145 type sequence T description binding site for residue NDP B 601 source : AC5 89) chain B residue 257 type sequence R description binding site for residue UFP B 602 source : AC6 90) chain B residue 316 type sequence W description binding site for residue UFP B 602 source : AC6 91) chain B residue 399 type sequence L description binding site for residue UFP B 602 source : AC6 92) chain B residue 402 type sequence C description binding site for residue UFP B 602 source : AC6 93) chain B residue 422 type sequence Q description binding site for residue UFP B 602 source : AC6 94) chain B residue 423 type sequence R description binding site for residue UFP B 602 source : AC6 95) chain B residue 424 type sequence S description binding site for residue UFP B 602 source : AC6 96) chain B residue 425 type sequence C description binding site for residue UFP B 602 source : AC6 97) chain B residue 426 type sequence D description binding site for residue UFP B 602 source : AC6 98) chain B residue 430 type sequence G description binding site for residue UFP B 602 source : AC6 99) chain B residue 434 type sequence N description binding site for residue UFP B 602 source : AC6 100) chain B residue 464 type sequence H description binding site for residue UFP B 602 source : AC6 101) chain B residue 466 type sequence Y description binding site for residue UFP B 602 source : AC6 102) chain E residue 382 type sequence R description binding site for residue UFP B 602 source : AC6 103) chain E residue 383 type sequence R description binding site for residue UFP B 602 source : AC6 104) chain B residue 284 type sequence K description binding site for residue D96 B 603 source : AC7 105) chain B residue 315 type sequence I description binding site for residue D96 B 603 source : AC7 106) chain B residue 319 type sequence N description binding site for residue D96 B 603 source : AC7 107) chain B residue 426 type sequence D description binding site for residue D96 B 603 source : AC7 108) chain B residue 429 type sequence L description binding site for residue D96 B 603 source : AC7 109) chain B residue 430 type sequence G description binding site for residue D96 B 603 source : AC7 110) chain B residue 515 type sequence I description binding site for residue D96 B 603 source : AC7 111) chain B residue 519 type sequence M description binding site for residue D96 B 603 source : AC7 112) chain B residue 520 type sequence A description binding site for residue D96 B 603 source : AC7 113) chain B residue 9 type sequence V description binding site for residue MTX B 604 source : AC8 114) chain B residue 10 type sequence V description binding site for residue MTX B 604 source : AC8 115) chain B residue 11 type sequence A description binding site for residue MTX B 604 source : AC8 116) chain B residue 25 type sequence L description binding site for residue MTX B 604 source : AC8 117) chain B residue 32 type sequence D description binding site for residue MTX B 604 source : AC8 118) chain B residue 33 type sequence L description binding site for residue MTX B 604 source : AC8 119) chain B residue 36 type sequence F description binding site for residue MTX B 604 source : AC8 120) chain B residue 37 type sequence S description binding site for residue MTX B 604 source : AC8 121) chain B residue 58 type sequence T description binding site for residue MTX B 604 source : AC8 122) chain B residue 62 type sequence I description binding site for residue MTX B 604 source : AC8 123) chain B residue 67 type sequence L description binding site for residue MTX B 604 source : AC8 124) chain B residue 70 type sequence R description binding site for residue MTX B 604 source : AC8 125) chain B residue 113 type sequence C description binding site for residue MTX B 604 source : AC8 126) chain B residue 119 type sequence Y description binding site for residue MTX B 604 source : AC8 127) chain B residue 134 type sequence T description binding site for residue MTX B 604 source : AC8 128) chain C residue 11 type sequence A description binding site for residue NDP C 601 source : AC9 129) chain C residue 19 type sequence I description binding site for residue NDP C 601 source : AC9 130) chain C residue 20 type sequence G description binding site for residue NDP C 601 source : AC9 131) chain C residue 23 type sequence G description binding site for residue NDP C 601 source : AC9 132) chain C residue 24 type sequence Q description binding site for residue NDP C 601 source : AC9 133) chain C residue 25 type sequence L description binding site for residue NDP C 601 source : AC9 134) chain C residue 55 type sequence G description binding site for residue NDP C 601 source : AC9 135) chain C residue 56 type sequence R description binding site for residue NDP C 601 source : AC9 136) chain C residue 57 type sequence K description binding site for residue NDP C 601 source : AC9 137) chain C residue 58 type sequence T description binding site for residue NDP C 601 source : AC9 138) chain C residue 75 type sequence I description binding site for residue NDP C 601 source : AC9 139) chain C residue 76 type sequence S description binding site for residue NDP C 601 source : AC9 140) chain C residue 77 type sequence S description binding site for residue NDP C 601 source : AC9 141) chain C residue 78 type sequence S description binding site for residue NDP C 601 source : AC9 142) chain C residue 92 type sequence R description binding site for residue NDP C 601 source : AC9 143) chain C residue 113 type sequence C description binding site for residue NDP C 601 source : AC9 144) chain C residue 114 type sequence G description binding site for residue NDP C 601 source : AC9 145) chain C residue 115 type sequence G description binding site for residue NDP C 601 source : AC9 146) chain C residue 116 type sequence E description binding site for residue NDP C 601 source : AC9 147) chain C residue 117 type sequence S description binding site for residue NDP C 601 source : AC9 148) chain C residue 121 type sequence D description binding site for residue NDP C 601 source : AC9 149) chain C residue 145 type sequence T description binding site for residue NDP C 601 source : AC9 150) chain A residue 382 type sequence R description binding site for residue UFP C 602 source : AD1 151) chain A residue 383 type sequence R description binding site for residue UFP C 602 source : AD1 152) chain C residue 257 type sequence R description binding site for residue UFP C 602 source : AD1 153) chain C residue 316 type sequence W description binding site for residue UFP C 602 source : AD1 154) chain C residue 399 type sequence L description binding site for residue UFP C 602 source : AD1 155) chain C residue 402 type sequence C description binding site for residue UFP C 602 source : AD1 156) chain C residue 403 type sequence H description binding site for residue UFP C 602 source : AD1 157) chain C residue 422 type sequence Q description binding site for residue UFP C 602 source : AD1 158) chain C residue 423 type sequence R description binding site for residue UFP C 602 source : AD1 159) chain C residue 424 type sequence S description binding site for residue UFP C 602 source : AD1 160) chain C residue 425 type sequence C description binding site for residue UFP C 602 source : AD1 161) chain C residue 426 type sequence D description binding site for residue UFP C 602 source : AD1 162) chain C residue 434 type sequence N description binding site for residue UFP C 602 source : AD1 163) chain C residue 464 type sequence H description binding site for residue UFP C 602 source : AD1 164) chain C residue 466 type sequence Y description binding site for residue UFP C 602 source : AD1 165) chain C residue 257 type sequence R description binding site for residue D96 C 603 source : AD2 166) chain C residue 284 type sequence K description binding site for residue D96 C 603 source : AD2 167) chain C residue 287 type sequence A description binding site for residue D96 C 603 source : AD2 168) chain C residue 315 type sequence I description binding site for residue D96 C 603 source : AD2 169) chain C residue 319 type sequence N description binding site for residue D96 C 603 source : AD2 170) chain C residue 426 type sequence D description binding site for residue D96 C 603 source : AD2 171) chain C residue 429 type sequence L description binding site for residue D96 C 603 source : AD2 172) chain C residue 430 type sequence G description binding site for residue D96 C 603 source : AD2 173) chain C residue 433 type sequence F description binding site for residue D96 C 603 source : AD2 174) chain C residue 515 type sequence I description binding site for residue D96 C 603 source : AD2 175) chain C residue 520 type sequence A description binding site for residue D96 C 603 source : AD2 176) chain C residue 9 type sequence V description binding site for residue MTX C 604 source : AD3 177) chain C residue 10 type sequence V description binding site for residue MTX C 604 source : AD3 178) chain C residue 11 type sequence A description binding site for residue MTX C 604 source : AD3 179) chain C residue 25 type sequence L description binding site for residue MTX C 604 source : AD3 180) chain C residue 32 type sequence D description binding site for residue MTX C 604 source : AD3 181) chain C residue 33 type sequence L description binding site for residue MTX C 604 source : AD3 182) chain C residue 36 type sequence F description binding site for residue MTX C 604 source : AD3 183) chain C residue 37 type sequence S description binding site for residue MTX C 604 source : AD3 184) chain C residue 58 type sequence T description binding site for residue MTX C 604 source : AD3 185) chain C residue 62 type sequence I description binding site for residue MTX C 604 source : AD3 186) chain C residue 67 type sequence L description binding site for residue MTX C 604 source : AD3 187) chain C residue 70 type sequence R description binding site for residue MTX C 604 source : AD3 188) chain C residue 113 type sequence C description binding site for residue MTX C 604 source : AD3 189) chain C residue 119 type sequence Y description binding site for residue MTX C 604 source : AD3 190) chain C residue 134 type sequence T description binding site for residue MTX C 604 source : AD3 191) chain E residue 11 type sequence A description binding site for residue NDP E 601 source : AD8 192) chain E residue 19 type sequence I description binding site for residue NDP E 601 source : AD8 193) chain E residue 20 type sequence G description binding site for residue NDP E 601 source : AD8 194) chain E residue 21 type sequence I description binding site for residue NDP E 601 source : AD8 195) chain E residue 23 type sequence G description binding site for residue NDP E 601 source : AD8 196) chain E residue 24 type sequence Q description binding site for residue NDP E 601 source : AD8 197) chain E residue 55 type sequence G description binding site for residue NDP E 601 source : AD8 198) chain E residue 56 type sequence R description binding site for residue NDP E 601 source : AD8 199) chain E residue 57 type sequence K description binding site for residue NDP E 601 source : AD8 200) chain E residue 58 type sequence T description binding site for residue NDP E 601 source : AD8 201) chain E residue 75 type sequence I description binding site for residue NDP E 601 source : AD8 202) chain E residue 76 type sequence S description binding site for residue NDP E 601 source : AD8 203) chain E residue 77 type sequence S description binding site for residue NDP E 601 source : AD8 204) chain E residue 78 type sequence S description binding site for residue NDP E 601 source : AD8 205) chain E residue 92 type sequence R description binding site for residue NDP E 601 source : AD8 206) chain E residue 113 type sequence C description binding site for residue NDP E 601 source : AD8 207) chain E residue 114 type sequence G description binding site for residue NDP E 601 source : AD8 208) chain E residue 115 type sequence G description binding site for residue NDP E 601 source : AD8 209) chain E residue 116 type sequence E description binding site for residue NDP E 601 source : AD8 210) chain E residue 117 type sequence S description binding site for residue NDP E 601 source : AD8 211) chain E residue 121 type sequence D description binding site for residue NDP E 601 source : AD8 212) chain E residue 145 type sequence T description binding site for residue NDP E 601 source : AD8 213) chain B residue 382 type sequence R description binding site for residue UFP E 602 source : AD9 214) chain B residue 383 type sequence R description binding site for residue UFP E 602 source : AD9 215) chain E residue 257 type sequence R description binding site for residue UFP E 602 source : AD9 216) chain E residue 316 type sequence W description binding site for residue UFP E 602 source : AD9 217) chain E residue 399 type sequence L description binding site for residue UFP E 602 source : AD9 218) chain E residue 402 type sequence C description binding site for residue UFP E 602 source : AD9 219) chain E residue 422 type sequence Q description binding site for residue UFP E 602 source : AD9 220) chain E residue 423 type sequence R description binding site for residue UFP E 602 source : AD9 221) chain E residue 424 type sequence S description binding site for residue UFP E 602 source : AD9 222) chain E residue 425 type sequence C description binding site for residue UFP E 602 source : AD9 223) chain E residue 426 type sequence D description binding site for residue UFP E 602 source : AD9 224) chain E residue 434 type sequence N description binding site for residue UFP E 602 source : AD9 225) chain E residue 464 type sequence H description binding site for residue UFP E 602 source : AD9 226) chain E residue 466 type sequence Y description binding site for residue UFP E 602 source : AD9 227) chain E residue 284 type sequence K description binding site for residue D96 E 603 source : AE1 228) chain E residue 315 type sequence I description binding site for residue D96 E 603 source : AE1 229) chain E residue 319 type sequence N description binding site for residue D96 E 603 source : AE1 230) chain E residue 399 type sequence L description binding site for residue D96 E 603 source : AE1 231) chain E residue 426 type sequence D description binding site for residue D96 E 603 source : AE1 232) chain E residue 429 type sequence L description binding site for residue D96 E 603 source : AE1 233) chain E residue 430 type sequence G description binding site for residue D96 E 603 source : AE1 234) chain E residue 433 type sequence F description binding site for residue D96 E 603 source : AE1 235) chain E residue 515 type sequence I description binding site for residue D96 E 603 source : AE1 236) chain E residue 520 type sequence A description binding site for residue D96 E 603 source : AE1 237) chain E residue 9 type sequence V description binding site for residue MTX E 604 source : AE2 238) chain E residue 10 type sequence V description binding site for residue MTX E 604 source : AE2 239) chain E residue 11 type sequence A description binding site for residue MTX E 604 source : AE2 240) chain E residue 25 type sequence L description binding site for residue MTX E 604 source : AE2 241) chain E residue 32 type sequence D description binding site for residue MTX E 604 source : AE2 242) chain E residue 36 type sequence F description binding site for residue MTX E 604 source : AE2 243) chain E residue 37 type sequence S description binding site for residue MTX E 604 source : AE2 244) chain E residue 58 type sequence T description binding site for residue MTX E 604 source : AE2 245) chain E residue 62 type sequence I description binding site for residue MTX E 604 source : AE2 246) chain E residue 67 type sequence L description binding site for residue MTX E 604 source : AE2 247) chain E residue 70 type sequence R description binding site for residue MTX E 604 source : AE2 248) chain E residue 113 type sequence C description binding site for residue MTX E 604 source : AE2 249) chain E residue 119 type sequence Y description binding site for residue MTX E 604 source : AE2 250) chain E residue 134 type sequence T description binding site for residue MTX E 604 source : AE2 251) chain A residue 18-40 type prosite sequence GIGINGQLPWSISEDLKFFSKIT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGingqLPWsise.DlkfFskiT source prosite : PS00075 252) chain A residue 382-410 type prosite sequence RRHILTAWNPSALSQMALPPCHVLSQYYV description THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrhIltaWNpsalsqma.....LpPCHvlsQYyV source prosite : PS00091

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