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Title
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In situ structure of rotavirus VP1 RNA-dependent RNA polymerase (TLP_RNA) |
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Classification
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VIRAL PROTEIN/TRANSFERASE |
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Compound
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Inner capsid protein VP2 |
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Source
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ORGANISM_COMMON: RV-A; ORGANISM_SCIENTIFIC: Rotavirus A (strain RVA/Monkey/United States/RRV/1975/G3P5B[3]); |
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Sequence
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A: |
PKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGE
KELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPD
YLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQDEETEG
VVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQH
QLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYI
RPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKEL
VSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCF
KTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMF
IRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIA
EQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRN
GHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNR
LGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLT
SVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERIN
DAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPD
DQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKI
AQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELM
RTGDYAQITNMLLNNQPVALVGALPFITDSSVISLVAKLD
ATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVP
TSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVS
ADTVEPINAVAFDNMRIMNEL
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| B: |
PKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGE
KELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPD
YLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQDEETEG
VVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQH
QLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYI
RPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKEL
VSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCF
KTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMF
IRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIA
EQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRN
GHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNR
LGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLT
SVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERIN
DAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPD
DQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKI
AQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELM
RTGDYAQITNMLLNNQPVALVGALPFITDSSVISLVAKLD
ATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVP
TSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVS
ADTVEPINAVAFDNMRIMNEL
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| C: |
KESILKKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGEK
ELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPDY
LLLKDMAVENKNSRDAGKVVDSETAAICDAIFQDEETEGV
VRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQHQ
LVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYIR
PNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKELV
STEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCFK
TLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMFI
RESLVACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIAE
QQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRNG
HVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRL
GQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLTS
VTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERIND
AVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPDD
QMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKIA
QGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELMR
TGDYAQITNMLLNNQPVALVGALPFITDSSVISLVAKLDA
TVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVPT
STTKVYKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVSA
DTVEPINAVAFDNMRIMNEL
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| D: |
EIKIADEVKKSNKEESKQLLEVLKTKEEHQKEVQYEILQK
TIPTFEPKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPV
YRANGEKELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQV
LTEMPDYLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQ
DEETEGVVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFN
EYFLQHQLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLP
STARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVV
PDLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQ
AANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTV
VPNDMFIRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQ
TPFQIAEQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVL
NDNIRNGHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGI
LLLSNRLGQLVDLTRLLAYNYETLMACITMNMQHVQTLTT
EKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSN
YNERINDAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFD
ISRVPDDQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIE
RASDKIAQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQI
NLEELMRTGDYAQITNMLLNNQPVALVGALPFITDSSVIS
LVAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVA
NYDWVPTSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSD
LLAFVSADTVEPINAVAFDNMRIMNEL
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| E: |
VQYEILQKTIPTFEPKESILKKLEDIKPEQVKKQTKLFRI
FEPRQLPVYRANGEKELRNRWYWKLKRDTLPDGDYDVREY
FLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVVDSETA
AICDAIFQDEETEGVVRRFIAEMRQRVQADRNVVNYPSIL
HPIDHAFNEYFLQHQLVEPLNNDIIFNYIPERIRNDVNYI
LNMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSN
YILARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQ
FLTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLI
SGMWLLTVVPNDMFIRESLVACQLAIINTIIYPAFGMQRM
HYRNGDPQTPFQIAEQQIQNFQVANWLHFVNNNQFRQVVI
DGVLNQVLNDNIRNGHVVNQLMEALMQLSRQQFPTMPVDY
KRSIQRGILLLSNRLGQLVDLTRLLAYNYETLMACITMNM
QHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYN
VNVNFHSNYNERINDAVAIITAANRLNLYQKKMKSIVEDF
LKRLQIFDISRVPDDQMYRLRDRLRLLPVEIRRLDIFNLI
LMNMEQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIAR
NLDGFQQINLEELMRTGDYAQITNMLLNNQPVALVGALPF
ITDSSVISLVAKLDATVFAQIVKLRKVDTLKPILYKINSD
SNDFYLVANYDWVPTSTTKVYKQIPQQFDFRASMHMLTSN
LTFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL
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| F: |
KEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQVKK
QTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTLPDG
DYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGK
VVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQADRNV
VNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIPERI
RNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLW
DTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEAL
TIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFVT
TNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTIIYP
AFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNNN
QFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSRQQF
PTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYETLM
ACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQ
TLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKM
KSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVEIRR
LDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERDEMY
GYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQPVA
LVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTLKPI
LYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDFRAS
MHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMN
EL
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| G: |
KEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQVKK
QTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTLPDG
DYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGK
VVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQADRNV
VNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIPERI
RNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLW
DTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEAL
TIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFVT
TNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTIIYP
AFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNNN
QFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSRQQF
PTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYETLM
ACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQ
TLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKM
KSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVEIRR
LDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERDEMY
GYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQPVA
LVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTLKPI
LYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDFRAS
MHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMN
EL
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| H: |
KEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQVKK
QTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTLPDG
DYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGK
VVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQADRNV
VNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIPERI
RNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLW
DTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEAL
TIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFVT
TNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTIIYP
AFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNNN
QFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSRQQF
PTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYETLM
ACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQ
TLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKM
KSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVEIRR
LDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERDEMY
GYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQPVA
LVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTLKPI
LYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDFRAS
MHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMN
EL
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| I: |
EHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQVKKQT
KLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTLPDGDY
DVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVV
DSETAAICDAIFQDEETEGVVRRFIAEMRQRVQADRNVVN
YPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIPERIRN
DVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDT
ITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEALTI
QSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTN
YMSLISGMWLLTVVPNDMFIRESLVACQLAIINTIIYPAF
GMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNNNQF
RQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSRQQFPT
MPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYETLMAC
ITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTL
FHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKKMKS
IVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVEIRRLD
IFNLILMNMEQIERASDKIAQGVIIAYRDMQLERDEMYGY
VNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQPVALV
GALPFITDSSVISLVAKLDATVFAQIVKLRKVDTLKPILY
KINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDFRASMH
MLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL
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| J: |
NKEESKQLLEVLKTKEEHQKEVQYEILQKTIPTFEPKESI
LKKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGEKELRN
RWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPDYLLLK
DMAVENKNSRDAGKVVDSETAAICDAIFQDEETEGVVRRF
IAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQHQLVEP
LNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYIRPNLL
QDRLNLHDNFESLWDTITTSNYILARSVVPDLKELVSTEA
QIQKMSQDLQLEALTIQSETQFLTGINSQAANDCFKTLIA
AMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMFIRESL
VACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIAEQQIQ
NFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRNGHVVN
QLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLV
DLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLTSVTSL
CMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERINDAVAI
ITAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPDDQMYR
LRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKIAQGVI
IAYRDMQLERDEMYGYVNIARNLDGFQQINLEELMRTGDY
AQITNMLLNNQPVALVGALPFITDSSVISLVAKLDATVFA
QIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVPTSTTK
VYKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVSADTVE
PINAVAFDNMRIMNEL
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| P: |
GKYNLILSEYLSFIYNSQSAVQIPIYYSSNSELENRCIEF
HSKCLENSKNGLSLKKLFVEYSDVIENATLLSILSYSYDK
YNAVERKLVKYAKGKPLEADLTVNELDYENNKITSELFPT
AEEYTDLLMDPAILTSLSSNLNAVMFWLEKHENDVAEKLK
IYKRRLDLFTIVASTVNKYGVPRHNAKYRYEYEVMKDKPY
YLVTWANSSIEMLMSVFSHEDYLIARELIVLSYSNRSTLA
KLVSSPMSILVALVDINGTFITNEELELEFSNKYVRAIVP
DQTFDELKQMLDNMRKAGLTDIPKMIQDWLVDCSIEKFPL
MAKIYSWSFHVGFRKQKMLDAALDQLKTEYTEDVDDEMYR
EYTMLIRDEVVKMLEEPVKHDDHLLQDSELAGLLSMSSAS
NGESRQLKFGRKTIFSTKKNMHVMDDMANGRYTPGIIPPV
NVDKPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKML
IYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNSMVLYTDV
SQWDSSQHNTQPFRKGIIMGLDMLANMTNDARVIQTLNLY
KQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANS
IANLALIKTVLSRISNKYSFATKIIRVDGDDNYAVLQFNT
EVTKQMVQDVSNDVRETYARMNTKVKALVSTVGIEIAKRY
IAGGKIFFRAGINLLNNEKKGQSTQWDQAAVLYSNYIVNR
LRGFETDREFILTKIMQMTSVAITGSLRLFPSERVLTTNS
TFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQKSGIADE
IAASSTFKNYVSRLSEQLLFSKNNIVSRGIALTEKAKLNS
YAPISLEKRRAQISALLTMLQKPVTFKSSKITINDILRDI
KPFFTVNEAHLPIQYQKFMPTLPDNVQYIIQCIGSRTYQI
EDDGSKSAISRLISKYSVYKPSIEELYKVISLHENEIQLY
LISLGIPKIDADTYVGSKIYSQDKYRILESYVYNLLSINY
GCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEV
INHAIKNGSWISLFCNYPKSEMIKLWKKMWNITSLRSPYT
NANFFQ
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Description
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