eF-site ID 6ogz-AEFGHIJKLMN PDB Code 6ogz Chain A, E, F, G, H, I, J, K, L, M, N Title In situ structure of Rotavirus RNA-dependent RNA polymerase at transcript-elongated state Classification viral protein/rna/transferase Compound RNA (5'-R(P*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*AP*UP*A)-3') Source ORGANISM_SCIENTIFIC: Rotavirus A; Sequence A:  GKYNLILSEYLSFIYNSQSAVQIPIYYSSNSELENRCIEF HSKCLENSKNGLSLKKLFVEYSDVIENATLLSILSYSYDK YNAVERKLVKYAKGKPLEADLTVNELDYENNKITSELFPT AEEYTDLLMDPAILTSLSSNLNAVMFWLEKHENDVAEKLK IYKRRLDLFTIVASTVNKYGVPRHNAKYRYEYEVMKDKPY YLVTWANSSIEMLMSVFSHEDYLIARELIVLSYSNRSTLA KLVSSPMSILVALVDINGTFITNEELELEFSNKYVRAIVP DQTFDELKQMLDNMRKAGLTDIPKMIQDWLVDCSIEKFPL MAKIYSWSFHVGFRKQKMLDAALDQLKTEYTEDVDDEMYR EYTMLIRDEVVKMLEEPVKHDDHLLQDSELAGLLSMSSAS NGESRQLKFGRKTIFSTKKNMHVMDDMANGRYTPGIIPPV NVDKPIPLGRRDVPGRRTRIIFILPYEYFIAQHAVVEKML IYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNSMVLYTDV SQWDSSQHNTQPFRKGIIMGLDMLANMTNDARVIQTLNLY KQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQTKAANS IANLALIKTVLSRISNKYSFATKIIRVDGDDNYAVLQFNT EVTKQMVQDVSNDVRETYARMNTKVKALVSTVGIEIAKRY IAGGKIFFRAGINLLNNEKKGQSTQWDQAAVLYSNYIVNR LRGFETDREFILTKIMQMTSVAITGSLRLFPSERVLTTNS TFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQKSGIADE IAASSTFKNYVSRLSEQLLFSKNNIVSRGIALTEKAKLNS YAPISLEKRRAQISALLTMLQKPVTFKSSKITINDILRDI KPFFTVNEAHLPIQYQKFMPTLPDNVQYIIQCIGSRTYQI EDDGSKSAISRLISKYSVYKPSIEELYKVISLHENEIQLY LISLGIPKIDADTYVGSKIYSQDKYRILESYVYNLLSINY GCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHLYAKLEV INHAIKNGSWISLFCNYPKSEMIKLWKKMWNITSLRSPYT NA E:  QYEILQKTIPTFEPKESILKKLEDIKPEQVKKQTKLFRIF EPRQLPVYRANGEKELRNRWYWKLKRDTLPDGDYDVREYF LNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVVDSETAA ICDAIFQDEETEGVVRRFIAEMRQRVQADRNVVNYPSILH PIDHAFNEYFLQHQLVEPLNNDIIFNYIPERIRNDVNYIL NMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNY ILARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQF LTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLIS GMWLLTVVPNDMFIRESLVACQLAIINTIIYPAFGMQRMH YRNGDPQTPFQIAEQQIQNFQVANWLHFVNNNQFRQVVID GVLNQVLNDNIRNGHVVNQLMEALMQLSRQQFPTMPVDYK RSIQRGILLLSNRLGQLVDLTRLLAYNYETLMACITMNMQ HVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNV NVNFHSNYNERINDAVAIITAANRLNLYQKKMKSIVEDFL KRLQIFDISRVPDDQMYRLRDRLRLLPVEIRRLDIFNLIL MNMEQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIARN LDGFQQINLEELMRTGDYAQITNMLLNNQPVALVGALPFI TDSSVISLVAKLDATVFAQIVKLRKVDTLKPILYKINSDS NDFYLVANYDWVPTSTTKVYKQIPQQFDFRASMHMLTSNL TFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL F:  TKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQVK KQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTLPD GDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRDAG KVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQADRN VVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIPER IRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFESL WDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQLEA LTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLDFV TTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTIIY PAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFVNN NQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSRQQ FPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYETL MACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIPSP QTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQKK MKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVEIR RLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERDEM YGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQPV ALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTLKP ILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDFRA SMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMRIM NEL G:  NKEESKQLLEVLKPKESILKKLEDIKPEQVKKQTKLFRIF EPRQLPVYRANGEKELRNRWYWKLKRDTLPDGDYDVREYF LNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVVDSETAA ICDAIFQDEETEGVVRRFIAEMRQRVQADRNVVNYPSILH PIDHAFNEYFLQHQLVEPLNNDIIFNYIPERIRNDVNYIL NMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNY ILARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQF LTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLIS GMWLLTVVPNDMFIRESLVACQLAIINTIIYPAFGMQRMH YRNGDPQTPFQIAEQQIQNFQVANWLHFVNNNQFRQVVID GVLNQVLNDNIRNGHVVNQLMEALMQLSRQQFPTMPVDYK RSIQRGILLLSNRLGQLVDLTRLLAYNYETLMACITMNMQ HVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNV NVNFHSNYNERINDAVAIITAANRLNLYQKKMKSIVEDFL KRLQIFDISRVPDDQMYRLRDRLRLLPVEIRRLDIFNLIL MNMEQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIARN LDGFQQINLEELMRTGDYAQITNMLLNNQPVALVGALPFI TDSSVISLVAKLDATVFAQIVKLRKVDTLKPILYKINSDS NDFYLVANYDWVPTSTTKVYKQIPQQFDFRASMHMLTSNL TFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL H:  LKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQ VKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTL PDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRD AGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQAD RNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIP ERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFE SLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQL EALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLD FVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTI IYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFV NNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSR QQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYE TLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIP SPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQ KKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVE IRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERD EMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQ PVALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTL KPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDF RASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMR IMNEL I:  PKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGE KELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPD YLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQDEETEG VVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQH QLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYI RPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKEL VSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCF KTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMF IRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIA EQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRN GHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNR LGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLT SVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERIN DAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPD DQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKI AQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELM RTGDYAQITNMLLNNQPVALVGALPFITDSSVISLVAKLD ATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVP TSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVS ADTVEPINAVAFDNMRIMNEL J:  LKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQ VKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTL PDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRD AGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQAD RNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIP ERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFE SLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQL EALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLD FVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTI IYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFV NNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSR QQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYE TLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIP SPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQ KKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVE IRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERD EMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQ PVALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTL KPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDF RASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMR IMNEL K:  PKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGE KELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPD YLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQDEETEG VVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQH QLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYI RPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKEL VSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCF KTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMF IRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIA EQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRN GHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNR LGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLT SVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERIN DAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPD DQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKI AQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELM RTGDYAQITNMLLNNQPVALVGALPFITDSSVISLVAKLD ATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVP TSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVS ADTVEPINAVAFDNMRIMNEL L:  LKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQ VKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTL PDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRD AGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQAD RNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIP ERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFE SLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQL EALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLD FVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTI IYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFV NNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSR QQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYE TLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIP SPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQ KKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVE IRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERD EMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQ PVALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTL KPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDF RASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMR IMNEL M:  IKIADEVKKSNKEESKQLLEVLKTKEEHQKEVQYEILQKT IPTFEPKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPVY RANGEKELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVL TEMPDYLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQD EETEGVVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNE YFLQHQLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPS TARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVVP DLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQA ANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVV PNDMFIRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQT PFQIAEQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLN DNIRNGHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGIL LLSNRLGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTE KLQLTSVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNY NERINDAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDI SRVPDDQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIER ASDKIAQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQIN LEELMRTGDYAQITNMLLNNQPVALVGALPFITDSSVISL VAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVAN YDWVPTSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSDL LAFVSADTVEPINAVAFDNMRIMNEL N:  LKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQ VKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTL PDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRD AGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQAD RNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIP ERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFE SLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQL EALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLD FVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTI IYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFV NNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSR QQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYE TLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIP SPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQ KKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVE IRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERD EMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQ PVALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTL KPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDF RASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMR IMNEL Description Functional site 1) chain A residue 452 type sequence R description binding site for residue UTP A 1101 source : AC1 2) chain A residue 457 type sequence R description binding site for residue UTP A 1101 source : AC1 3) chain A residue 460 type sequence R description binding site for residue UTP A 1101 source : AC1 4) chain A residue 520 type sequence D description binding site for residue UTP A 1101 source : AC1 5) chain A residue 521 type sequence V description binding site for residue UTP A 1101 source : AC1 6) chain A residue 522 type sequence S description binding site for residue UTP A 1101 source : AC1 7) chain A residue 523 type sequence Q description binding site for residue UTP A 1101 source : AC1 8) chain A residue 524 type sequence W description binding site for residue UTP A 1101 source : AC1 9) chain A residue 525 type sequence D description binding site for residue UTP A 1101 source : AC1 10) chain A residue 591 type sequence S description binding site for residue UTP A 1101 source : AC1 11) chain A residue 596 type sequence T description binding site for residue UTP A 1101 source : AC1 12) chain A residue 600 type sequence N description binding site for residue UTP A 1101 source : AC1 13) chain A residue 631 type sequence D description binding site for residue UTP A 1101 source : AC1 14) chain A residue 632 type sequence D description binding site for residue UTP A 1101 source : AC1 15) chain A residue 11 type sequence Y description binding site for residue GTP A 1102 source : AC2 16) chain A residue 83 type sequence N description binding site for residue GTP A 1102 source : AC2 17) chain A residue 143 type sequence N description binding site for residue GTP A 1102 source : AC2 18) chain A residue 184 type sequence R description binding site for residue GTP A 1102 source : AC2 19) chain A residue 185 type sequence H description binding site for residue GTP A 1102 source : AC2 20) chain A residue 189 type sequence Y description binding site for residue GTP A 1102 source : AC2 21) chain A residue 749 type sequence R description binding site for residue GTP A 1102 source : AC2

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