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Title
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In situ structure of Rotavirus RNA-dependent RNA polymerase at duplex-open state |
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Classification
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viral protein/transferase/rna |
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Compound
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RNA-dependent RNA polymerase of rotavirus A |
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Source
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ORGANISM_SCIENTIFIC: Rotavirus A; |
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Sequence
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A: |
GKYNLILSEYLSFIYNSQSAVQIPIYYSSNSENATLLSIL
SYSYDKYNAVERKLVKYAKGKPLEADLTVNELDYENNKIT
SELFPTAEEYTDLLMDPAILTSLSSNLNAVMFWLEKHEND
VAEKLKIYKRRLDLFTIVASTVNKYGVPRHNAKYRYEYEV
MKDKPYYLVTWANSSIEMLMSVFSHEDYLIARELIVLSYS
NRSTLAKLVSSPMSILVALVDINGTFITNEELELEFSNKY
VRAIVPDQTFDELKQMLDNMRKAGLTDIPKMIQDWLVDCS
IEKFPLMAKIYSWSFHVGFRKQKMLDAALDQLKTEYTEDV
DDEMYREYTMLIRDEVVKMLEEPVKHDDHLLQDSELAGLL
SMSSASNGESRQLKFGRKTIFSTKKNMHVMDDMANGRYTP
GIIPPVNVDKPIPLGRRDVPGRRTRIIFILPYEYFIAQHA
VVEKMLIYAKHTREYAEFYSQSNQLLSYGDVTRFLSNNSM
VLYTDVSQWDSSQHNTQPFRKGIIMGLDMLANMTNDARVI
QTLNLYKQTQINLMDSYVQIPDGNVIKKIQYGAVASGEKQ
TKAANSIANLALIKTVLSRISNKYSFATKIIRVDGDDNYA
VLQFNTEVTKQMVQDVSNDVRETYARMNTKVKALVSTVGI
EIAKRYIAGGKIFFRAGINLLNNEKKGQSTQWDQAAVLYS
NYIVNRLRGFETDREFILTKIMQMTSVAITGSLRLFPSER
VLTTNSTFKVFDSEDFIIEYGTTDDEVYIQRAFMSLSSQK
SGIADEIAASSTFKNYVSRLSEQLLFSKNNIVSRGIALTE
KAKLNSYAPISLEKRRAQISALLTMLQKPVTFKSSKITIN
DILRDIKPFFTVNEAHLPIQYQKFMPTLPDNVQYIIQCIG
SRTYQIEDDGSKSAISRLISKYSVYKPSIEELYKVISLHE
NEIQLYLISLGIPKIDADTYVGSKIYSQDKYRILESYVYN
LLSINYGCYQLFDFNSPDLEKLIRIPFKGKIPAVTFILHL
YAKLEVINHAIKNGSWISLFCNYPKSEMIKLWKKMWNITS
LRSPYTNANFFQD
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| C: |
QYEILQKTIPTFEPKESILKKLEDIKPEQVKKQTKLFRIF
EPRQLPVYRANGEKELRNRWYWKLKRDTLPDGDYDVREYF
LNLYDQVLTEMPDYLLLKDMAVENKNSRDAGKVVDSETAA
ICDAIFQDEETEGVVRRFIAEMRQRVQADRNVVNYPSILH
PIDHAFNEYFLQHQLVEPLNNDIIFNYIPERIRNDVNYIL
NMDRNLPSTARYIRPNLLQDRLNLHDNFESLWDTITTSNY
ILARSVVPDLKELVSTEAQIQKMSQDLQLEALTIQSETQF
LTGINSQAANDCFKTLIAAMLSQRTMSLDFVTTNYMSLIS
GMWLLTVVPNDMFIRESLVACQLAIINTIIYPAFGMQRMH
YRNGDPQTPFQIAEQQIQNFQVANWLHFVNNNQFRQVVID
GVLNQVLNDNIRNGHVVNQLMEALMQLSRQQFPTMPVDYK
RSIQRGILLLSNRLGQLVDLTRLLAYNYETLMACITMNMQ
HVQTLTTEKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNV
NVNFHSNYNERINDAVAIITAANRLNLYQKKMKSIVEDFL
KRLQIFDISRVPDDQMYRLRDRLRLLPVEIRRLDIFNLIL
MNMEQIERASDKIAQGVIIAYRDMQLERDEMYGYVNIARN
LDGFQQINLEELMRTGDYAQITNMLLNNQPVALVGALPFI
TDSSVISLVAKLDATVFAQIVKLRKVDTLKPILYKINSDS
NDFYLVANYDWVPTSTTKVYKQIPQQFDFRASMHMLTSNL
TFTVYSDLLAFVSADTVEPINAVAFDNMRIMNEL
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| D: |
KEESKQLLEVLKTKEEHQKEVQYEILQKTIPTFEPKESIL
KKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGEKELRNR
WYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPDYLLLKD
MAVENKNSRDAGKVVDSETAAICDAIFQDEETEGVVRRFI
AEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQHQLVEPL
NNDIIFNYIPERIRNDVNYILNMDRNLPSTARYIRPNLLQ
DRLNLHDNFESLWDTITTSNYILARSVVPDLKELVSTEAQ
IQKMSQDLQLEALTIQSETQFLTGINSQAANDCFKTLIAA
MLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMFIRESLV
ACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIAEQQIQN
FQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRNGHVVNQ
LMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVD
LTRLLAYNYETLMACITMNMQHVQTLTTEKLQLTSVTSLC
MLIGNATVIPSPQTLFHYYNVNVNFHSNYNERINDAVAII
TAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPDDQMYRL
RDRLRLLPVEIRRLDIFNLILMNMEQIERASDKIAQGVII
AYRDMQLERDEMYGYVNIARNLDGFQQINLEELMRTGDYA
QITNMLLNNQPVALVGALPFITDSSVISLVAKLDATVFAQ
IVKLRKVDTLKPILYKINSDSNDFYLVANYDWVPTSTTKV
YKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVSADTVEP
INAVAFDNMRIMNEL
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| E: |
PKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGE
KELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPD
YLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQDEETEG
VVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQH
QLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYI
RPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKEL
VSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCF
KTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMF
IRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIA
EQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRN
GHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNR
LGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLT
SVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERIN
DAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPD
DQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKI
AQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELM
RTGDYAQITNMLLNNQPVALVGALPFITDSSVISLVAKLD
ATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVP
TSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVS
ADTVEPINAVAFDNMRIMNEL
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| F: |
LKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQ
VKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTL
PDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRD
AGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQAD
RNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIP
ERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFE
SLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQL
EALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLD
FVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTI
IYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFV
NNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSR
QQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYE
TLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIP
SPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQ
KKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVE
IRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERD
EMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQ
PVALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTL
KPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDF
RASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMR
IMNEL
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| G: |
PKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPVYRANGE
KELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQVLTEMPD
YLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQDEETEG
VVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFNEYFLQH
QLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLPSTARYI
RPNLLQDRLNLHDNFESLWDTITTSNYILARSVVPDLKEL
VSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQAANDCF
KTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTVVPNDMF
IRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQTPFQIA
EQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVLNDNIRN
GHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGILLLSNR
LGQLVDLTRLLAYNYETLMACITMNMQHVQTLTTEKLQLT
SVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSNYNERIN
DAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFDISRVPD
DQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIERASDKI
AQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQINLEELM
RTGDYAQITNMLLNNQPVALVGALPFITDSSVISLVAKLD
ATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVANYDWVP
TSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSDLLAFVS
ADTVEPINAVAFDNMRIMNEL
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| H: |
LKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQ
VKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTL
PDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRD
AGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQAD
RNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIP
ERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFE
SLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQL
EALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLD
FVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTI
IYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFV
NNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSR
QQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYE
TLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIP
SPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQ
KKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVE
IRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERD
EMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQ
PVALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTL
KPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDF
RASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMR
IMNEL
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| I: |
QLLEVLKTKEEHQKEVQYEILQKTIPTFEPKESILKKLED
IKPEQVKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKL
KRDTLPDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVEN
KNSRDAGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQ
RVQADRNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDII
FNYIPERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNL
HDNFESLWDTITTSNYILARSVVPDLKELVSTEAQIQKMS
QDLQLEALTIQSETQFLTGINSQAANDCFKTLIAAMLSQR
TMSLDFVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLA
IINTIIYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVAN
WLHFVNNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEAL
MQLSRQQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLL
AYNYETLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGN
ATVIPSPQTLFHYYNVNVNFHSNYNERINDAVAIITAANR
LNLYQKKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLR
LLPVEIRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDM
QLERDEMYGYVNIARNLDGFQQINLEELMRTGDYAQITNM
LLNNQPVALVGALPFITDSSVISLVAKLDATVFAQIVKLR
KVDTLKPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIP
QQFDFRASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVA
FDNMRIMNEL
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| J: |
LKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQ
VKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTL
PDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRD
AGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQAD
RNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIP
ERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFE
SLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQL
EALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLD
FVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTI
IYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFV
NNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSR
QQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYE
TLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIP
SPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQ
KKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVE
IRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERD
EMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQ
PVALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTL
KPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDF
RASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMR
IMNEL
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| K: |
EIKIADEVKKSNKEESKQLLEVLKTKEEHQKEVQYEILQK
TIPTFEPKESILKKLEDIKPEQVKKQTKLFRIFEPRQLPV
YRANGEKELRNRWYWKLKRDTLPDGDYDVREYFLNLYDQV
LTEMPDYLLLKDMAVENKNSRDAGKVVDSETAAICDAIFQ
DEETEGVVRRFIAEMRQRVQADRNVVNYPSILHPIDHAFN
EYFLQHQLVEPLNNDIIFNYIPERIRNDVNYILNMDRNLP
STARYIRPNLLQDRLNLHDNFESLWDTITTSNYILARSVV
PDLKELVSTEAQIQKMSQDLQLEALTIQSETQFLTGINSQ
AANDCFKTLIAAMLSQRTMSLDFVTTNYMSLISGMWLLTV
VPNDMFIRESLVACQLAIINTIIYPAFGMQRMHYRNGDPQ
TPFQIAEQQIQNFQVANWLHFVNNNQFRQVVIDGVLNQVL
NDNIRNGHVVNQLMEALMQLSRQQFPTMPVDYKRSIQRGI
LLLSNRLGQLVDLTRLLAYNYETLMACITMNMQHVQTLTT
EKLQLTSVTSLCMLIGNATVIPSPQTLFHYYNVNVNFHSN
YNERINDAVAIITAANRLNLYQKKMKSIVEDFLKRLQIFD
ISRVPDDQMYRLRDRLRLLPVEIRRLDIFNLILMNMEQIE
RASDKIAQGVIIAYRDMQLERDEMYGYVNIARNLDGFQQI
NLEELMRTGDYAQITNMLLNNQPVALVGALPFITDSSVIS
LVAKLDATVFAQIVKLRKVDTLKPILYKINSDSNDFYLVA
NYDWVPTSTTKVYKQIPQQFDFRASMHMLTSNLTFTVYSD
LLAFVSADTVEPINAVAFDNMRIMNEL
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| L: |
LKTKEEHQKEVQYEILQKTIPTFEPKESILKKLEDIKPEQ
VKKQTKLFRIFEPRQLPVYRANGEKELRNRWYWKLKRDTL
PDGDYDVREYFLNLYDQVLTEMPDYLLLKDMAVENKNSRD
AGKVVDSETAAICDAIFQDEETEGVVRRFIAEMRQRVQAD
RNVVNYPSILHPIDHAFNEYFLQHQLVEPLNNDIIFNYIP
ERIRNDVNYILNMDRNLPSTARYIRPNLLQDRLNLHDNFE
SLWDTITTSNYILARSVVPDLKELVSTEAQIQKMSQDLQL
EALTIQSETQFLTGINSQAANDCFKTLIAAMLSQRTMSLD
FVTTNYMSLISGMWLLTVVPNDMFIRESLVACQLAIINTI
IYPAFGMQRMHYRNGDPQTPFQIAEQQIQNFQVANWLHFV
NNNQFRQVVIDGVLNQVLNDNIRNGHVVNQLMEALMQLSR
QQFPTMPVDYKRSIQRGILLLSNRLGQLVDLTRLLAYNYE
TLMACITMNMQHVQTLTTEKLQLTSVTSLCMLIGNATVIP
SPQTLFHYYNVNVNFHSNYNERINDAVAIITAANRLNLYQ
KKMKSIVEDFLKRLQIFDISRVPDDQMYRLRDRLRLLPVE
IRRLDIFNLILMNMEQIERASDKIAQGVIIAYRDMQLERD
EMYGYVNIARNLDGFQQINLEELMRTGDYAQITNMLLNNQ
PVALVGALPFITDSSVISLVAKLDATVFAQIVKLRKVDTL
KPILYKINSDSNDFYLVANYDWVPTSTTKVYKQIPQQFDF
RASMHMLTSNLTFTVYSDLLAFVSADTVEPINAVAFDNMR
IMNEL
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| N: |
AGCC
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Description
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