|
Title
|
Splayed open prefusion RSV F captured by CR9501 and motavizumab Fabs |
|
Classification
|
Viral protein/immune system |
|
Compound
|
Fusion glycoprotein F0,Fibritin |
|
Source
|
(6OE5) |
|
|
Sequence
|
A: |
YLSALRTGWYTSVITIELSNIKEIKCAKVKLIKQELDKYK
NAVTELQLLMQSTSAIASGVAVSKVLHLEGEVNKIKSALL
STNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNPNIE
TVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELL
SLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLA
YVVQLPLYGVIDTPCWKLDRGWYCDNAGSVSFTCKVQSNR
VFCDTMITVNKQ
|
| B: |
QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIR
QPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQV
VLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSS
ASTKGPSVFPLAPSTAALGCLVKDYFPEPVTVSWNSGALT
SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNH
KPSNTKVDKKVEP
|
| C: |
DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPG
KAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPD
DFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPS
DEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE
SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGL
SSPVTKSFNRG
|
| H: |
VQLVQSGPGLVKPSQTLALTCTVSGASINSDNYYWTWIRQ
RPGGGLEWIGHISYTGNTYYTPSLKSRLSMSLETSQSQFS
LRLTSVTAADSAVYFCAACGAYVLISNCGWFDSWGQGTQV
TVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL
GTQTYICNVNHKPSNTKVDKRVEPK
|
| L: |
EIVMTQSPSSLSASIGDRVTITCQASQDISTYLNWYQQKP
GQAPRLLIYGASNLETGVPSRFTGSGYGTDFSVTISSLQP
EDIATYYCQQYQYLPYTFAPGTKVEIKRTVAAPSVFIFPP
SDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQ
ESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQG
LSSPVTKSFNRG
|
|
|
Description
|
(1) |
Fusion glycoprotein F0, Motavizumab Fab Heavy Chain, Motavizumab Fab Light Chain, CR9501 Fab Heavy Chain, CR9501 Fab Light Chain
|
