eF-site ID 6o9z-ABCDEFGHIJLM PDB Code 6o9z Chain A, B, C, D, E, F, G, H, I, J, L, M click to enlarge Title Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens Classification TRANSLATION Compound Translation initiation factor eIF-2B subunit epsilon Source (IF2A_HUMAN) Sequence A:  PPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTL EFLTATGVQETFVFCCWKAAQIKEHLLKSKWCRPTSLNVV RIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVISNIN ITRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDN VVVAVDSTTNRVLHFQKTQGLRRFAFPLSLFQGSSDGVEV RYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNE EILGNQIHMHVTAKEYGARVSNLHMYSAVCADVIRRWVYP LTPEANFTDSTTQSCTHSRHNIYRGPEVSLGHGSILEENV LLGSGTVIGSNCFITNSVIGPGCHIGDNVVLDQTYLWQGV RVAAGAQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPN ITLPEGSVISLHPPDAEEDEDDGEFS B:  PPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTL EFLTATGVQETFVFCCWKAAQIKEHLLKSKWCRPTSLNVV RIITSELYRSLGDVLRDVDAKALVRSDFLLVYGDVISNIN ITRALEEHRLRRKLEKNVSVMTMIFKESSPSHPTRCHEDN VVVAVDSTTNRVLHFQKTQGLRRFAFPLSLFQGSSDGVEV RYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNE EILGNQIHMHVTAKEYGARVSNLHMYSAVCADVIRRWVYP LTPEANFTDSTTQSCTHSRHNIYRGPEVSLGHGSILEENV LLGSGTVIGSNCFITNSVIGPGCHIGDNVVLDQTYLWQGV RVAAGAQIHQSLLCDNAEVKERVTLKPRSVLTSQVVVGPN ITLPEGSVISLHPPDAEEDEDDGEFS C:  GSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIIT DHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLK IIREEYGRLHGYAQLQSNIIEAINELLVELEGTMENIAAQ ALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAEC APFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVII GTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFKL SPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVFD YVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL D:  GSELSERIESFVETLKRGGGPRSSEEMARETLGLLRQIIT DHRWSNAGELMELIRREGRRMTAAQPSETTVGNMVRRVLK IIREEYGRLHGHYAQLQSNIIEAINELLVELEGTMENIAA QALEHIHSNEVIMTIGFSRTVEAFLKEAARKRKFHVIVAE CAPFCQGHEMAVNLSKAGIETTVMTDAAIFAVMSRVNKVI IGTKTILANGALRAVTGTHTLALAAKHHSTPLIVCAPMFK LSPQFPNEEDSFHKFVAPEEVLPFTEGDILEKVSVHCPVF DYVPPELITLFISNIGGNAPSYIYRLMSELYHPDDHVL E:  QVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHP AMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPN EELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEIT SVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQ KISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRP WLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGA HALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCE RVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLL NLVYDVTPPELVDLVITELGMIPCSSVPVVLRV F:  QVPTRKDYGSKVSLFSHLPQYSRQNSLTQFMSIPSSVIHP AMVRLGLQYSQGLVSGSNARCIALLRALQQVIQDYTTPPN EELSRDLVNKLKPYMSFLTQCRPLSASMHNAIKFLNKEIT SVGSSKREEEAKSELRAAIDRYVQEKIVLAAQAISRFAYQ KISNGDVILVYGCSSLVSRILQEAWTEGRRFRVVVVDSRP WLEGRHTLRSLVHAGVPASYLLIPAASYVLPEVSKVLLGA HALLANGSVMSRVGTAQLALVARAHNVPVLVCCETYKFCE RVQTDAFVSNELDDPDDLQCKRGEHVALANWQNHASLRLL NLVYDVTPPELVDLVITELGMIPCSSVPVVLRV G:  MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGE TIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLAS LEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLS GKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGV VENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP LNQQDVPDKFKYEEHPWVDYTAPSLITLLFTDLGVLTPSA VSDELIKLYL H:  MDDKELIEYFKSQMKEDPDMASAVAAIRTLLEFLKRDKGE TIQGLRANLTSAIETLCGVDSSVAVSSGGELFLRFISLAS LEYSDYSKCKKIMIERGELFLRRISLSRNKIADLCHTFIK DGATILTHAYSRVVLRVLEAAVAAKKRFSVYVTESQPDLS GKKMAKALCHLNVPVTVVLDAAVGYIMEKADLVIVGAEGV VENGGIINKIGTNQMAVCAKAQNKPFYVVAESFKFVRLFP LNQQDVPDKFKYEEHPWVDYTAPSLITLLFTDLGVLTPSA VSDELIKLYL I:  MEFQAVVMAVGLPVGNKPLIWYPLNLLERVGFEEVIVVTT RDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPK LKTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKRD FIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFH TGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQ FSLKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSR J:  MEFQAVVMAVGLPVGNKPLIWYPLNLLERVGFEEVIVVTT RDVQKALCAEFKMKMKPDIVCIPDDADMGTADSLRYIYPK LKTDVLVLSCDLITDVALHEVVDLFRAYDASLAMLMRKRD FIGVDSTGKRLLFMANEADLDEELVIKGSILQKHPRIRFH TGLVDAHLYCLKKYIVDFLMENGSITSIRSELIPYLVRKQ FSLKSLDIYSFIKEANTLNLAPYDACWNACRGDRWEDLSR L:  CRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGM ILLSELXRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDL SKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDE QLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDS LDLNEDEREVLINNIN M:  CRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGM ILLSELXRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDL SKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDE QLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDS LDLNEDEREVLINNIN Description (1)  Translation initiation factor eIF-2B subunit epsilon, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit delta, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit gamma, Eukaryotic translation initiation factor 2 subunit 1 Functional site 1) chain L residue 48 type MOD_RES sequence S description Phosphoserine; by HRI => ECO:0000250|UniProtKB:P83268 source Swiss-Prot : SWS_FT_FI1 2) chain M residue 48 type MOD_RES sequence S description Phosphoserine; by HRI => ECO:0000250|UniProtKB:P83268 source Swiss-Prot : SWS_FT_FI1 3) chain A residue 61 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q64350 source Swiss-Prot : SWS_FT_FI8 4) chain B residue 217 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q64350 source Swiss-Prot : SWS_FT_FI8 5) chain A residue 103 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q64350 source Swiss-Prot : SWS_FT_FI8 6) chain A residue 141 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q64350 source Swiss-Prot : SWS_FT_FI8 7) chain A residue 217 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q64350 source Swiss-Prot : SWS_FT_FI8 8) chain B residue 61 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q64350 source Swiss-Prot : SWS_FT_FI8 9) chain B residue 103 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q64350 source Swiss-Prot : SWS_FT_FI8 10) chain B residue 141 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:Q64350 source Swiss-Prot : SWS_FT_FI8 11) chain L residue 51 type MOD_RES sequence X description Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI2 12) chain M residue 51 type MOD_RES sequence X description Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI2 13) chain L residue 140 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 14) chain M residue 140 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 15) chain B residue 130 type MOD_RES sequence S description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI3 16) chain L residue 157 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 17) chain M residue 157 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 18) chain B residue 466 type MOD_RES sequence S description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI5

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