eF-site ID 6o8c-B PDB Code 6o8c Chain B click to enlarge Title Crystal structure of STING CTT in complex with TBK1 Classification IMMUNE SYSTEM Compound Serine/threonine-protein kinase TBK1 Source (STING_HUMAN) Sequence B:  LDGICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYA VKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEE TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLT DFGAGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVT FYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ KAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQE KCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIYIHSYN TAAVFHELVYKQTKIVSSNQELIYEGRRLVLELGRLAQHF PKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDG DASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVELV KDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVNL EAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGG LLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQFKKDK AERRLAYNEEQIHKFDKQKLYYHATKAMSHFSEECVRKYE AFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDY TNE Description Functional site 1) chain B residue 15 type sequence L description binding site for residue BX7 B 701 source : AC2 2) chain B residue 18 type sequence G description binding site for residue BX7 B 701 source : AC2 3) chain B residue 23 type sequence V description binding site for residue BX7 B 701 source : AC2 4) chain B residue 36 type sequence A description binding site for residue BX7 B 701 source : AC2 5) chain B residue 86 type sequence M description binding site for residue BX7 B 701 source : AC2 6) chain B residue 87 type sequence E description binding site for residue BX7 B 701 source : AC2 7) chain B residue 88 type sequence F description binding site for residue BX7 B 701 source : AC2 8) chain B residue 89 type sequence C description binding site for residue BX7 B 701 source : AC2 9) chain B residue 90 type sequence P description binding site for residue BX7 B 701 source : AC2 10) chain B residue 92 type sequence G description binding site for residue BX7 B 701 source : AC2 11) chain B residue 93 type sequence S description binding site for residue BX7 B 701 source : AC2 12) chain B residue 95 type sequence Y description binding site for residue BX7 B 701 source : AC2 13) chain B residue 96 type sequence T description binding site for residue BX7 B 701 source : AC2 14) chain B residue 139 type sequence G description binding site for residue BX7 B 701 source : AC2 15) chain B residue 142 type sequence M description binding site for residue BX7 B 701 source : AC2 16) chain B residue 156 type sequence T description binding site for residue BX7 B 701 source : AC2 17) chain B residue 157 type sequence D description binding site for residue BX7 B 701 source : AC2 18) chain B residue 30 type MOD_RES sequence K description Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499 source Swiss-Prot : SWS_FT_FI4 19) chain B residue 401 type MOD_RES sequence K description Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499 source Swiss-Prot : SWS_FT_FI4 20) chain B residue 15 type MOD_RES sequence L description Phosphoserine; by MAP3K7 => ECO:0000269|PubMed:37832545 source Swiss-Prot : SWS_FT_FI2 21) chain B residue 38 type MOD_RES sequence K description Phosphoserine; by MAP3K7 => ECO:0000269|PubMed:37832545 source Swiss-Prot : SWS_FT_FI2

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