eF-site ID 6o8c-ABDE PDB Code 6o8c Chain A, B, D, E click to enlarge Title Crystal structure of STING CTT in complex with TBK1 Classification IMMUNE SYSTEM Compound Serine/threonine-protein kinase TBK1 Source (STING_HUMAN) Sequence A:  GLDGICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLY AVKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEE ETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIV LRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKL TDFGAATEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGV TFYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGV QKAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQ EKCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIYIHSY NTAAVFHELVYKQTKIVSSNQELIYEGRRLVLELGRLAQH FPKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLD GDASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVEL VKDDYNETVHKKTEVVITLDFCIRNIEKTVKVVNLEAAEL GEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGGLLADT WAHQEGTHPRDRNVEKLQVLLNCITEIYYQFKKDKAERRL AYNEEQIHKFDKQKLYYHATKAMSHFSEECVRKYEAFKDK SEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDYT B:  LDGICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYA VKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEE TTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVL RDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLT DFGAGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVT FYHAATGSLPFRPFEGPRRNKEVMYKIITGKPSGAISGVQ KAENGPIDWSGDMPLSCSLSQGLQALLTPVLANILEADQE KCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIYIHSYN TAAVFHELVYKQTKIVSSNQELIYEGRRLVLELGRLAQHF PKTTEENPIFVTSREQLNTVGLRYEKISLPKIHPRYDLDG DASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVELV KDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVNL EAAELGEISDIHTKLLRLSSSQGTIESSLQDISSRLSPGG LLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQFKKDK AERRLAYNEEQIHKFDKQKLYYHATKAMSHFSEECVRKYE AFKDKSEEWMRKMLHLRKQLLSLTNQCFDIEEEVSKYQDY TNE D:  SGMEKPLPLRTDFS E:  MEKPLPLRTDFS Description Functional site 1) chain A residue 15 type sequence L description binding site for residue BX7 A 701 source : AC1 2) chain A residue 16 type sequence G description binding site for residue BX7 A 701 source : AC1 3) chain A residue 17 type sequence Q description binding site for residue BX7 A 701 source : AC1 4) chain A residue 18 type sequence G description binding site for residue BX7 A 701 source : AC1 5) chain A residue 21 type sequence A description binding site for residue BX7 A 701 source : AC1 6) chain A residue 23 type sequence V description binding site for residue BX7 A 701 source : AC1 7) chain A residue 36 type sequence A description binding site for residue BX7 A 701 source : AC1 8) chain A residue 38 type sequence K description binding site for residue BX7 A 701 source : AC1 9) chain A residue 86 type sequence M description binding site for residue BX7 A 701 source : AC1 10) chain A residue 87 type sequence E description binding site for residue BX7 A 701 source : AC1 11) chain A residue 88 type sequence F description binding site for residue BX7 A 701 source : AC1 12) chain A residue 89 type sequence C description binding site for residue BX7 A 701 source : AC1 13) chain A residue 92 type sequence G description binding site for residue BX7 A 701 source : AC1 14) chain A residue 93 type sequence S description binding site for residue BX7 A 701 source : AC1 15) chain A residue 96 type sequence T description binding site for residue BX7 A 701 source : AC1 16) chain A residue 139 type sequence G description binding site for residue BX7 A 701 source : AC1 17) chain A residue 142 type sequence M description binding site for residue BX7 A 701 source : AC1 18) chain A residue 156 type sequence T description binding site for residue BX7 A 701 source : AC1 19) chain B residue 15 type sequence L description binding site for residue BX7 B 701 source : AC2 20) chain B residue 18 type sequence G description binding site for residue BX7 B 701 source : AC2 21) chain B residue 23 type sequence V description binding site for residue BX7 B 701 source : AC2 22) chain B residue 36 type sequence A description binding site for residue BX7 B 701 source : AC2 23) chain B residue 86 type sequence M description binding site for residue BX7 B 701 source : AC2 24) chain B residue 87 type sequence E description binding site for residue BX7 B 701 source : AC2 25) chain B residue 88 type sequence F description binding site for residue BX7 B 701 source : AC2 26) chain B residue 89 type sequence C description binding site for residue BX7 B 701 source : AC2 27) chain B residue 90 type sequence P description binding site for residue BX7 B 701 source : AC2 28) chain B residue 92 type sequence G description binding site for residue BX7 B 701 source : AC2 29) chain B residue 93 type sequence S description binding site for residue BX7 B 701 source : AC2 30) chain B residue 95 type sequence Y description binding site for residue BX7 B 701 source : AC2 31) chain B residue 96 type sequence T description binding site for residue BX7 B 701 source : AC2 32) chain B residue 139 type sequence G description binding site for residue BX7 B 701 source : AC2 33) chain B residue 142 type sequence M description binding site for residue BX7 B 701 source : AC2 34) chain B residue 156 type sequence T description binding site for residue BX7 B 701 source : AC2 35) chain B residue 157 type sequence D description binding site for residue BX7 B 701 source : AC2 36) chain A residue 15-38 type prosite sequence LGQGATANVFRGRHKKTGDLYAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGATANVFrGrhkktgdl..........YAVK source prosite : PS00107 37) chain D residue 366 type MOD_RES sequence S description Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499 source Swiss-Prot : SWS_FT_FI4 38) chain A residue 401 type MOD_RES sequence K description Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499 source Swiss-Prot : SWS_FT_FI4 39) chain B residue 30 type MOD_RES sequence K description Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 401 type MOD_RES sequence K description Phosphoserine; by TBK1 => ECO:0000269|PubMed:25636800, ECO:0000269|PubMed:27302953, ECO:0000269|PubMed:32753499 source Swiss-Prot : SWS_FT_FI4 41) chain B residue 15 type MOD_RES sequence L description Phosphoserine; by MAP3K7 => ECO:0000269|PubMed:37832545 source Swiss-Prot : SWS_FT_FI2 42) chain B residue 38 type MOD_RES sequence K description Phosphoserine; by MAP3K7 => ECO:0000269|PubMed:37832545 source Swiss-Prot : SWS_FT_FI2

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