eF-site ID 6o8b-ABDE
PDB Code 6o8b
Chain A, B, D, E

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Title Crystal structure of STING CTD in complex with TBK1
Classification IMMUNE SYSTEM
Compound Stimulator of interferon genes protein
Source (TBK1_HUMAN)
Sequence A:  PGLDGICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDL
FAIKVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIE
EETTTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLI
VLRDVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYK
LTDFGAARELEDDEQFVELYGTEEYLHPDMYERAVLRKDH
QKKYGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVM
YKIITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQ
VLLTPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVF
SLQQMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIY
EGRRLVLEPGRLAQHFPKTTEENPIFVVSREPLDTIGLIY
EKISLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLL
YQELMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRN
IEKTVKVYEKLAAELGEISDIHTKLLRLSSSQGTIETSLQ
DIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLNCMT
EIYYQFKKDQAERRLAYNEEQIHKFDKQKLYYHATKAMTH
FTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQCFDI
EEEVSKYQEYTNELQE
B:  DGICQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLFAI
KVFNNISFLRPVDVQMREFEVLKKLNHKNIVKLFAIEEET
TTRHKVLIMEFCPCGSLYTVLEEPSNAYGLPESEFLIVLR
DVVGGMNHLRENGIVHRNIKPGNIMRVIGEDGQSVYKLTD
FGAARELEDDEQFVELYGTEEYLHPDMYERAVLRKDHQKK
YGATVDLWSIGVTFYHAATGSLPFRPFEGPRRNKEVMYKI
ITGKPSGAISGVQKAENGPIDWSGDMPVSCSLSRGLQVLL
TPVLANILEADQEKCWGFDQFFAETSDILHRMVIHVFSLQ
QMTAHKIYIHSYNTATIFHELVYKQTKIISSNQELIYEGR
RLVLEPGRLAQHFPKTTEENPIFVVSREPLDTIGLIYEKI
SLPKVHPRYDLDGDASMAKAITGVVCYACRIASTLLLYQE
LMRKGIRWLIELIKDDYNETVHKKTEVVITLDFCIRNIEK
TVKVYEKLMKINLEAAELGEISDIHTKLLRLSSSQGTIET
SLQDIDSRLSPGGSLADAWAHQEGTHPKDRNVEKLQVLLN
CMTEIYYQFKKDQAERRLAYNEEQIHKFDKQKLYYHATKA
MTHFTDECVKKYEAFLNKSEEWIRKMLHLRKQLLSLTNQC
FDIEEEVSKYQEYTNEL
D:  EKPLPLREDMW
E:  MEKPLPLREDMW
Description


Functional site

1) chain A
residue 15
type
sequence L
description binding site for residue BX7 A 701
source : AC1

2) chain A
residue 17
type
sequence Q
description binding site for residue BX7 A 701
source : AC1

3) chain A
residue 36
type
sequence A
description binding site for residue BX7 A 701
source : AC1

4) chain A
residue 38
type
sequence K
description binding site for residue BX7 A 701
source : AC1

5) chain A
residue 86
type
sequence M
description binding site for residue BX7 A 701
source : AC1

6) chain A
residue 87
type
sequence E
description binding site for residue BX7 A 701
source : AC1

7) chain A
residue 88
type
sequence F
description binding site for residue BX7 A 701
source : AC1

8) chain A
residue 89
type
sequence C
description binding site for residue BX7 A 701
source : AC1

9) chain A
residue 92
type
sequence G
description binding site for residue BX7 A 701
source : AC1

10) chain A
residue 93
type
sequence S
description binding site for residue BX7 A 701
source : AC1

11) chain A
residue 96
type
sequence T
description binding site for residue BX7 A 701
source : AC1

12) chain A
residue 139
type
sequence G
description binding site for residue BX7 A 701
source : AC1

13) chain A
residue 142
type
sequence M
description binding site for residue BX7 A 701
source : AC1

14) chain A
residue 156
type
sequence T
description binding site for residue BX7 A 701
source : AC1

15) chain B
residue 15
type
sequence L
description binding site for residue BX7 B 701
source : AC2

16) chain B
residue 16
type
sequence G
description binding site for residue BX7 B 701
source : AC2

17) chain B
residue 17
type
sequence Q
description binding site for residue BX7 B 701
source : AC2

18) chain B
residue 18
type
sequence G
description binding site for residue BX7 B 701
source : AC2

19) chain B
residue 23
type
sequence V
description binding site for residue BX7 B 701
source : AC2

20) chain B
residue 36
type
sequence A
description binding site for residue BX7 B 701
source : AC2

21) chain B
residue 38
type
sequence K
description binding site for residue BX7 B 701
source : AC2

22) chain B
residue 86
type
sequence M
description binding site for residue BX7 B 701
source : AC2

23) chain B
residue 88
type
sequence F
description binding site for residue BX7 B 701
source : AC2

24) chain B
residue 89
type
sequence C
description binding site for residue BX7 B 701
source : AC2

25) chain B
residue 92
type
sequence G
description binding site for residue BX7 B 701
source : AC2

26) chain B
residue 93
type
sequence S
description binding site for residue BX7 B 701
source : AC2

27) chain B
residue 95
type
sequence Y
description binding site for residue BX7 B 701
source : AC2

28) chain B
residue 139
type
sequence G
description binding site for residue BX7 B 701
source : AC2

29) chain B
residue 142
type
sequence M
description binding site for residue BX7 B 701
source : AC2

30) chain B
residue 156
type
sequence T
description binding site for residue BX7 B 701
source : AC2

31) chain B
residue 157
type
sequence D
description binding site for residue BX7 B 701
source : AC2

32) chain A
residue 135
type ACT_SITE
sequence N
description Proton acceptor => ECO:0000305|PubMed:23453971, ECO:0000305|PubMed:23453972, ECO:0000305|PubMed:30842653
source Swiss-Prot : SWS_FT_FI1

33) chain B
residue 135
type ACT_SITE
sequence N
description Proton acceptor => ECO:0000305|PubMed:23453971, ECO:0000305|PubMed:23453972, ECO:0000305|PubMed:30842653
source Swiss-Prot : SWS_FT_FI1

34) chain A
residue 15
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

35) chain B
residue 15
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

36) chain A
residue 38
type BINDING
sequence K
description BINDING => ECO:0000305
source Swiss-Prot : SWS_FT_FI3

37) chain B
residue 38
type BINDING
sequence K
description BINDING => ECO:0000305
source Swiss-Prot : SWS_FT_FI3

38) chain A
residue 30
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23453971
source Swiss-Prot : SWS_FT_FI5

39) chain A
residue 401
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23453971
source Swiss-Prot : SWS_FT_FI5

40) chain B
residue 30
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23453971
source Swiss-Prot : SWS_FT_FI5

41) chain B
residue 401
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23453971
source Swiss-Prot : SWS_FT_FI5

42) chain A
residue 15-38
type prosite
sequence LGQGATANVFRGRHKKTGDLFAIK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGQGATANVFrGrhkktgdl..........FAIK
source prosite : PS00107

43) chain A
residue 172
type MOD_RES
sequence E
description Phosphoserine; by autocatalysis and IKKB => ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23746807
source Swiss-Prot : SWS_FT_FI4

44) chain B
residue 172
type MOD_RES
sequence E
description Phosphoserine; by autocatalysis and IKKB => ECO:0000269|PubMed:11839743, ECO:0000269|PubMed:22851595, ECO:0000269|PubMed:23746807
source Swiss-Prot : SWS_FT_FI4


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