eF-site ID 6o52-B PDB Code 6o52 Chain B click to enlarge Title Room temperature structure of binary complex of native hAChE with BW284c51 Classification HYDROLASE Compound Acetylcholinesterase Source (ACES_HUMAN) Sequence B:  EDAELLVTVRGGRLRGIRLKTPGGPVSAFLGIPFAEPPMG PRRFLPPEPKQPWSGVVDATTFQSVCYQYVDTLYPGFEGT EMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGF YSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPG SREAPGNVGLLDQRLALQWVQENVAAFGGDPTSVTLFGES AGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGE ARRRATQLAHLVGCPPGGTGGNDTELVACLRTRPAQVLVN HEWHVLPQESVFRFSFVPVVDGDFLSDTPEALINAGDFHG LQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAEFLAGV RVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVG DHNVVCPVAQLAGRLAAQGARVYAYVFEHRASTLSWPLWM GVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANF ARTGDPNEPRDPKAPQWPPYTAGAQQYVSLDLRPLEVRRG LRAQACAFWNRFLPKLLSAT Description Functional site 1) chain B residue 76 type sequence L description binding site for residue EBW B 601 source : AC2 2) chain B residue 86 type sequence W description binding site for residue EBW B 601 source : AC2 3) chain B residue 124 type sequence Y description binding site for residue EBW B 601 source : AC2 4) chain B residue 202 type sequence E description binding site for residue EBW B 601 source : AC2 5) chain B residue 203 type sequence S description binding site for residue EBW B 601 source : AC2 6) chain B residue 286 type sequence W description binding site for residue EBW B 601 source : AC2 7) chain B residue 297 type sequence F description binding site for residue EBW B 601 source : AC2 8) chain B residue 337 type sequence Y description binding site for residue EBW B 601 source : AC2 9) chain B residue 338 type sequence F description binding site for residue EBW B 601 source : AC2 10) chain B residue 341 type sequence Y description binding site for residue EBW B 601 source : AC2 11) chain B residue 447 type sequence H description binding site for residue EBW B 601 source : AC2 12) chain B residue 203 type ACT_SITE sequence S description Acyl-ester intermediate source Swiss-Prot : SWS_FT_FI1 13) chain B residue 334 type ACT_SITE sequence E description Charge relay system source Swiss-Prot : SWS_FT_FI2 14) chain B residue 447 type ACT_SITE sequence H description Charge relay system source Swiss-Prot : SWS_FT_FI2 15) chain B residue 86 type BINDING sequence W description BINDING => ECO:0007744|PDB:4EY5 source Swiss-Prot : SWS_FT_FI3 16) chain B residue 133 type BINDING sequence Y description BINDING => ECO:0007744|PDB:4EY5 source Swiss-Prot : SWS_FT_FI3 17) chain B residue 337 type BINDING sequence Y description BINDING => ECO:0007744|PDB:4EY5 source Swiss-Prot : SWS_FT_FI3 18) chain B residue 122 type BINDING sequence G description BINDING => ECO:0007744|PDB:4BDT source Swiss-Prot : SWS_FT_FI4 19) chain B residue 203 type BINDING sequence S description BINDING => ECO:0007744|PDB:4BDT source Swiss-Prot : SWS_FT_FI4 20) chain B residue 439 type BINDING sequence W description BINDING => ECO:0007744|PDB:4BDT source Swiss-Prot : SWS_FT_FI4 21) chain B residue 447 type BINDING sequence H description BINDING => ECO:0007744|PDB:4BDT source Swiss-Prot : SWS_FT_FI4 22) chain B residue 202 type BINDING sequence E description BINDING => ECO:0007744|PDB:4EY6 source Swiss-Prot : SWS_FT_FI5 23) chain B residue 265 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23035744, ECO:0007744|PDB:4EY4, ECO:0007744|PDB:4EY5, ECO:0007744|PDB:4EY6, ECO:0007744|PDB:4EY7 source Swiss-Prot : SWS_FT_FI6 24) chain B residue 464 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23035744, ECO:0007744|PDB:4EY8 source Swiss-Prot : SWS_FT_FI8 25) chain B residue 350 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11053835, ECO:0000269|PubMed:20408548, ECO:0000269|PubMed:23035744, ECO:0000269|PubMed:23679855, ECO:0007744|PDB:1B41, ECO:0007744|PDB:1F8U, ECO:0007744|PDB:2X8B, ECO:0007744|PDB:4BDT, ECO:0007744|PDB:4EY4, ECO:0007744|PDB:4EY5, ECO:0007744|PDB:4EY6, ECO:0007744|PDB:4EY7, ECO:0007744|PDB:4EY8 source Swiss-Prot : SWS_FT_FI7

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