eF-site ID 6o48-B PDB Code 6o48 Chain B click to enlarge Title Wild-type HIV-1 protease in complex with a substrate analog CA-p2 Classification HYDROLASE, VIRAL PROTEIN Compound HIV-1 protease Source (Q5RZ08_9HIV1) Sequence B:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF Description Functional site 1) chain B residue 41 type sequence R description binding site for residue CL A 502 source : AC2 2) chain B residue 5 type sequence L description binding site for residue FMT A 503 source : AC3 3) chain B residue 41 type sequence R description binding site for residue FMT A 503 source : AC3 4) chain B residue 25 type sequence D description binding site for residue 0Q4 B 201 source : AC4 5) chain B residue 27 type sequence G description binding site for residue 0Q4 B 201 source : AC4 6) chain B residue 28 type sequence A description binding site for residue 0Q4 B 201 source : AC4 7) chain B residue 29 type sequence D description binding site for residue 0Q4 B 201 source : AC4 8) chain B residue 30 type sequence D description binding site for residue 0Q4 B 201 source : AC4 9) chain B residue 45 type sequence K description binding site for residue 0Q4 B 201 source : AC4 10) chain B residue 46 type sequence M description binding site for residue 0Q4 B 201 source : AC4 11) chain B residue 47 type sequence I description binding site for residue 0Q4 B 201 source : AC4 12) chain B residue 48 type sequence G description binding site for residue 0Q4 B 201 source : AC4 13) chain B residue 49 type sequence G description binding site for residue 0Q4 B 201 source : AC4 14) chain B residue 50 type sequence I description binding site for residue 0Q4 B 201 source : AC4 15) chain B residue 82 type sequence V description binding site for residue 0Q4 B 201 source : AC4 16) chain B residue 84 type sequence I description binding site for residue 0Q4 B 201 source : AC4 17) chain B residue 6 type sequence W description binding site for residue CL B 202 source : AC5 18) chain B residue 12 type sequence T description binding site for residue GOL B 203 source : AC6 19) chain B residue 65 type sequence E description binding site for residue GOL B 203 source : AC6 20) chain B residue 66 type sequence I description binding site for residue GOL B 203 source : AC6 21) chain B residue 67 type sequence A description binding site for residue GOL B 203 source : AC6 22) chain B residue 68 type sequence G description binding site for residue GOL B 203 source : AC6 23) chain B residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000269|PubMed:2476069 source Swiss-Prot : SWS_FT_FI2

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