eF-site ID 6o48-AB PDB Code 6o48 Chain A, B click to enlarge Title Wild-type HIV-1 protease in complex with a substrate analog CA-p2 Classification HYDROLASE, VIRAL PROTEIN Compound HIV-1 protease Source (Q5RZ08_9HIV1) Sequence A:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF B:  PQITLWKRPLVTIKIGGQLKEALLDTGADDTVIEEMSLPG RWKPKMIGGIGGFIKVRQYDQIIIEIAGHKAIGTVLVGPT PVNIIGRNLLTQIGATLNF Description Functional site 1) chain A residue 60 type sequence D description binding site for residue NA A 501 source : AC1 2) chain A residue 73 type sequence G description binding site for residue CL A 502 source : AC2 3) chain A residue 74 type sequence T description binding site for residue CL A 502 source : AC2 4) chain A residue 88 type sequence N description binding site for residue CL A 502 source : AC2 5) chain B residue 41 type sequence R description binding site for residue CL A 502 source : AC2 6) chain A residue 87 type sequence R description binding site for residue FMT A 503 source : AC3 7) chain A residue 88 type sequence N description binding site for residue FMT A 503 source : AC3 8) chain A residue 91 type sequence T description binding site for residue FMT A 503 source : AC3 9) chain B residue 5 type sequence L description binding site for residue FMT A 503 source : AC3 10) chain B residue 41 type sequence R description binding site for residue FMT A 503 source : AC3 11) chain A residue 6 type sequence W description binding site for residue 0Q4 B 201 source : AC4 12) chain A residue 8 type sequence R description binding site for residue 0Q4 B 201 source : AC4 13) chain A residue 23 type sequence L description binding site for residue 0Q4 B 201 source : AC4 14) chain A residue 25 type sequence D description binding site for residue 0Q4 B 201 source : AC4 15) chain A residue 27 type sequence G description binding site for residue 0Q4 B 201 source : AC4 16) chain A residue 28 type sequence A description binding site for residue 0Q4 B 201 source : AC4 17) chain A residue 29 type sequence D description binding site for residue 0Q4 B 201 source : AC4 18) chain A residue 48 type sequence G description binding site for residue 0Q4 B 201 source : AC4 19) chain A residue 49 type sequence G description binding site for residue 0Q4 B 201 source : AC4 20) chain A residue 81 type sequence P description binding site for residue 0Q4 B 201 source : AC4 21) chain A residue 82 type sequence V description binding site for residue 0Q4 B 201 source : AC4 22) chain B residue 25 type sequence D description binding site for residue 0Q4 B 201 source : AC4 23) chain B residue 27 type sequence G description binding site for residue 0Q4 B 201 source : AC4 24) chain B residue 28 type sequence A description binding site for residue 0Q4 B 201 source : AC4 25) chain B residue 29 type sequence D description binding site for residue 0Q4 B 201 source : AC4 26) chain B residue 30 type sequence D description binding site for residue 0Q4 B 201 source : AC4 27) chain B residue 45 type sequence K description binding site for residue 0Q4 B 201 source : AC4 28) chain B residue 46 type sequence M description binding site for residue 0Q4 B 201 source : AC4 29) chain B residue 47 type sequence I description binding site for residue 0Q4 B 201 source : AC4 30) chain B residue 48 type sequence G description binding site for residue 0Q4 B 201 source : AC4 31) chain B residue 49 type sequence G description binding site for residue 0Q4 B 201 source : AC4 32) chain B residue 50 type sequence I description binding site for residue 0Q4 B 201 source : AC4 33) chain B residue 82 type sequence V description binding site for residue 0Q4 B 201 source : AC4 34) chain B residue 84 type sequence I description binding site for residue 0Q4 B 201 source : AC4 35) chain B residue 6 type sequence W description binding site for residue CL B 202 source : AC5 36) chain A residue 18 type sequence Q description binding site for residue GOL B 203 source : AC6 37) chain A residue 36 type sequence M description binding site for residue GOL B 203 source : AC6 38) chain A residue 37 type sequence S description binding site for residue GOL B 203 source : AC6 39) chain B residue 12 type sequence T description binding site for residue GOL B 203 source : AC6 40) chain B residue 65 type sequence E description binding site for residue GOL B 203 source : AC6 41) chain B residue 66 type sequence I description binding site for residue GOL B 203 source : AC6 42) chain B residue 67 type sequence A description binding site for residue GOL B 203 source : AC6 43) chain B residue 68 type sequence G description binding site for residue GOL B 203 source : AC6 44) chain A residue 22-33 type prosite sequence ALLDTGADDTVI description ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. ALLDTGADDTVI source prosite : PS00141 45) chain A residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 source Swiss-Prot : SWS_FT_FI1 46) chain B residue 25 type ACT_SITE sequence D description For protease activity; shared with dimeric partner => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:12924029 source Swiss-Prot : SWS_FT_FI1 47) chain A residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000269|PubMed:2476069 source Swiss-Prot : SWS_FT_FI2 48) chain B residue 99 type SITE sequence F description Cleavage; by viral protease => ECO:0000269|PubMed:2476069 source Swiss-Prot : SWS_FT_FI2

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