eF-site ID 6o0m-A
PDB Code 6o0m
Chain A

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Title crystal structure of BCL-2 F104L mutation with venetoclax
Classification APOPTOSIS
Compound Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2
Source (BCL2_HUMAN)
Sequence A:  GYDNREIVMKYIHYKLSQRGYEWDAGDSEVVHLTLRQAGD
DLSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV
NWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLN
RHLHTWIQDNGGWDAFVELYG
Description


Functional site

1) chain A
residue 12
type
sequence R
description binding site for residue LBM A 301
source : AC1

2) chain A
residue 100
type
sequence A
description binding site for residue LBM A 301
source : AC1

3) chain A
residue 103
type
sequence D
description binding site for residue LBM A 301
source : AC1

4) chain A
residue 104
type
sequence L
description binding site for residue LBM A 301
source : AC1

5) chain A
residue 107
type
sequence R
description binding site for residue LBM A 301
source : AC1

6) chain A
residue 112
type
sequence F
description binding site for residue LBM A 301
source : AC1

7) chain A
residue 115
type
sequence M
description binding site for residue LBM A 301
source : AC1

8) chain A
residue 136
type
sequence E
description binding site for residue LBM A 301
source : AC1

9) chain A
residue 143
type
sequence N
description binding site for residue LBM A 301
source : AC1

10) chain A
residue 144
type
sequence W
description binding site for residue LBM A 301
source : AC1

11) chain A
residue 145
type
sequence G
description binding site for residue LBM A 301
source : AC1

12) chain A
residue 148
type
sequence V
description binding site for residue LBM A 301
source : AC1

13) chain A
residue 149
type
sequence A
description binding site for residue LBM A 301
source : AC1

14) chain A
residue 152
type
sequence E
description binding site for residue LBM A 301
source : AC1

15) chain A
residue 153
type
sequence F
description binding site for residue LBM A 301
source : AC1

16) chain A
residue 156
type
sequence V
description binding site for residue LBM A 301
source : AC1

17) chain A
residue 190
type
sequence Q
description binding site for residue LBM A 301
source : AC1

18) chain A
residue 198
type
sequence F
description binding site for residue LBM A 301
source : AC1

19) chain A
residue 202
type
sequence Y
description binding site for residue LBM A 301
source : AC1

20) chain A
residue 108
type
sequence Y
description binding site for residue PEG A 302
source : AC2

21) chain A
residue 12
type
sequence R
description binding site for residue PEG A 303
source : AC3

22) chain A
residue 16
type
sequence M
description binding site for residue PEG A 303
source : AC3

23) chain A
residue 174
type
sequence A
description binding site for residue PEG A 303
source : AC3

24) chain A
residue 175
type
sequence L
description binding site for residue PEG A 303
source : AC3

25) chain A
residue 178
type
sequence T
description binding site for residue PEG A 303
source : AC3

26) chain A
residue 127
type
sequence R
description binding site for residue PEG A 304
source : AC4

27) chain A
residue 130
type
sequence F
description binding site for residue PEG A 304
source : AC4

28) chain A
residue 163
type
sequence N
description binding site for residue PEG A 304
source : AC4

29) chain A
residue 176
type
sequence W
description binding site for residue PEG A 304
source : AC4

30) chain A
residue 180
type
sequence Y
description binding site for residue PEG A 304
source : AC4

31) chain A
residue 12
type
sequence R
description binding site for residue PEG A 305
source : AC5

32) chain A
residue 191
type
sequence D
description binding site for residue PEG A 305
source : AC5

33) chain A
residue 34
type SITE
sequence D
description Cleavage; by caspase-3
source Swiss-Prot : SWS_FT_FI1

34) chain A
residue 137-155
type prosite
sequence LFRDGVNWGRIVAFFEFGG
description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG
source prosite : PS01080

35) chain A
residue 188-199
type prosite
sequence WIQDNGGWDAFV
description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV
source prosite : PS01258

36) chain A
residue 93-107
type prosite
sequence VHLTLRQAGDDLSRR
description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhltLRqAGDDLSRR
source prosite : PS01259

37) chain A
residue 10-30
type prosite
sequence DNREIVMKYIHYKLSQRGYEW
description BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW
source prosite : PS01260


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