eF-site ID 6o0l-AC PDB Code 6o0l Chain A, C click to enlarge Title crystal structure of BCL-2 G101V mutation with venetoclax Classification APOPTOSIS Compound Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2 Source (BCL2_HUMAN) Sequence A:  YDNREIVMKYIHYKLSQRGYEWDAGSEVVHLTLRQAVDDF SRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNW GRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRH LHTWIQDNGGWDAFVELYG C:  GYDNREIVMKYIHYKLSQRGYEWDAGSEVVHLTLRQAVDD FSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVN WGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR HLHTWIQDNGGWDAFVELYG Description Functional site 1) chain A residue 12 type sequence R description binding site for residue LBM A 301 source : AC1 2) chain A residue 100 type sequence A description binding site for residue LBM A 301 source : AC1 3) chain A residue 103 type sequence D description binding site for residue LBM A 301 source : AC1 4) chain A residue 107 type sequence R description binding site for residue LBM A 301 source : AC1 5) chain A residue 108 type sequence Y description binding site for residue LBM A 301 source : AC1 6) chain A residue 137 type sequence L description binding site for residue LBM A 301 source : AC1 7) chain A residue 144 type sequence W description binding site for residue LBM A 301 source : AC1 8) chain A residue 145 type sequence G description binding site for residue LBM A 301 source : AC1 9) chain A residue 148 type sequence V description binding site for residue LBM A 301 source : AC1 10) chain A residue 149 type sequence A description binding site for residue LBM A 301 source : AC1 11) chain A residue 152 type sequence E description binding site for residue LBM A 301 source : AC1 12) chain A residue 153 type sequence F description binding site for residue LBM A 301 source : AC1 13) chain A residue 156 type sequence V description binding site for residue LBM A 301 source : AC1 14) chain A residue 198 type sequence F description binding site for residue LBM A 301 source : AC1 15) chain A residue 202 type sequence Y description binding site for residue LBM A 301 source : AC1 16) chain A residue 12 type sequence R description binding site for residue PEG A 302 source : AC2 17) chain A residue 16 type sequence M description binding site for residue PEG A 302 source : AC2 18) chain A residue 143 type sequence N description binding site for residue PEG A 303 source : AC3 19) chain A residue 178 type sequence T description binding site for residue PEG A 303 source : AC3 20) chain A residue 179 type sequence E description binding site for residue CL A 304 source : AC4 21) chain A residue 182 type sequence N description binding site for residue CL A 304 source : AC4 22) chain A residue 183 type sequence R description binding site for residue CL A 304 source : AC4 23) chain C residue 12 type sequence R description binding site for residue LBM C 301 source : AC5 24) chain C residue 100 type sequence A description binding site for residue LBM C 301 source : AC5 25) chain C residue 103 type sequence D description binding site for residue LBM C 301 source : AC5 26) chain C residue 107 type sequence R description binding site for residue LBM C 301 source : AC5 27) chain C residue 108 type sequence Y description binding site for residue LBM C 301 source : AC5 28) chain C residue 136 type sequence E description binding site for residue LBM C 301 source : AC5 29) chain C residue 137 type sequence L description binding site for residue LBM C 301 source : AC5 30) chain C residue 144 type sequence W description binding site for residue LBM C 301 source : AC5 31) chain C residue 145 type sequence G description binding site for residue LBM C 301 source : AC5 32) chain C residue 148 type sequence V description binding site for residue LBM C 301 source : AC5 33) chain C residue 149 type sequence A description binding site for residue LBM C 301 source : AC5 34) chain C residue 152 type sequence E description binding site for residue LBM C 301 source : AC5 35) chain C residue 153 type sequence F description binding site for residue LBM C 301 source : AC5 36) chain C residue 156 type sequence V description binding site for residue LBM C 301 source : AC5 37) chain C residue 198 type sequence F description binding site for residue LBM C 301 source : AC5 38) chain C residue 202 type sequence Y description binding site for residue LBM C 301 source : AC5 39) chain C residue 12 type sequence R description binding site for residue PEG C 302 source : AC6 40) chain C residue 12 type sequence R description binding site for residue PEG C 303 source : AC7 41) chain C residue 143 type sequence N description binding site for residue PEG C 303 source : AC7 42) chain C residue 146 type sequence R description binding site for residue PEG C 303 source : AC7 43) chain C residue 179 type sequence E description binding site for residue CL C 304 source : AC8 44) chain C residue 182 type sequence N description binding site for residue CL C 304 source : AC8 45) chain C residue 183 type sequence R description binding site for residue CL C 304 source : AC8 46) chain A residue 137-155 type prosite sequence LFRDGVNWGRIVAFFEFGG description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG source prosite : PS01080 47) chain A residue 188-199 type prosite sequence WIQDNGGWDAFV description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV source prosite : PS01258 48) chain A residue 10-30 type prosite sequence DNREIVMKYIHYKLSQRGYEW description BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW source prosite : PS01260

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