eF-site ID 6o0l-C PDB Code 6o0l Chain C click to enlarge Title crystal structure of BCL-2 G101V mutation with venetoclax Classification APOPTOSIS Compound Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2 Source (BCL2_HUMAN) Sequence C:  GYDNREIVMKYIHYKLSQRGYEWDAGSEVVHLTLRQAVDD FSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVN WGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNR HLHTWIQDNGGWDAFVELYG Description Functional site 1) chain C residue 12 type sequence R description binding site for residue LBM C 301 source : AC5 2) chain C residue 100 type sequence A description binding site for residue LBM C 301 source : AC5 3) chain C residue 103 type sequence D description binding site for residue LBM C 301 source : AC5 4) chain C residue 107 type sequence R description binding site for residue LBM C 301 source : AC5 5) chain C residue 108 type sequence Y description binding site for residue LBM C 301 source : AC5 6) chain C residue 136 type sequence E description binding site for residue LBM C 301 source : AC5 7) chain C residue 137 type sequence L description binding site for residue LBM C 301 source : AC5 8) chain C residue 144 type sequence W description binding site for residue LBM C 301 source : AC5 9) chain C residue 145 type sequence G description binding site for residue LBM C 301 source : AC5 10) chain C residue 148 type sequence V description binding site for residue LBM C 301 source : AC5 11) chain C residue 149 type sequence A description binding site for residue LBM C 301 source : AC5 12) chain C residue 152 type sequence E description binding site for residue LBM C 301 source : AC5 13) chain C residue 153 type sequence F description binding site for residue LBM C 301 source : AC5 14) chain C residue 156 type sequence V description binding site for residue LBM C 301 source : AC5 15) chain C residue 198 type sequence F description binding site for residue LBM C 301 source : AC5 16) chain C residue 202 type sequence Y description binding site for residue LBM C 301 source : AC5 17) chain C residue 12 type sequence R description binding site for residue PEG C 302 source : AC6 18) chain C residue 12 type sequence R description binding site for residue PEG C 303 source : AC7 19) chain C residue 143 type sequence N description binding site for residue PEG C 303 source : AC7 20) chain C residue 146 type sequence R description binding site for residue PEG C 303 source : AC7 21) chain C residue 179 type sequence E description binding site for residue CL C 304 source : AC8 22) chain C residue 182 type sequence N description binding site for residue CL C 304 source : AC8 23) chain C residue 183 type sequence R description binding site for residue CL C 304 source : AC8

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