eF-site ID 6o0k-A PDB Code 6o0k Chain A click to enlarge Title crystal structure of BCL-2 with venetoclax Classification APOPTOSIS Compound Apoptosis regulator Bcl-2 Source (BCL2_HUMAN) Sequence A:  YDNREIVMKYIHYKLSQRGYEWDAGDDSEVVHLTLRQAGD DFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGV NWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLN RHLHTWIQDNGGWDAFVELYG Description Functional site 1) chain A residue 12 type sequence R description binding site for residue LBM A 301 source : AC1 2) chain A residue 100 type sequence A description binding site for residue LBM A 301 source : AC1 3) chain A residue 103 type sequence D description binding site for residue LBM A 301 source : AC1 4) chain A residue 104 type sequence F description binding site for residue LBM A 301 source : AC1 5) chain A residue 107 type sequence R description binding site for residue LBM A 301 source : AC1 6) chain A residue 108 type sequence Y description binding site for residue LBM A 301 source : AC1 7) chain A residue 111 type sequence D description binding site for residue LBM A 301 source : AC1 8) chain A residue 115 type sequence M description binding site for residue LBM A 301 source : AC1 9) chain A residue 137 type sequence L description binding site for residue LBM A 301 source : AC1 10) chain A residue 143 type sequence N description binding site for residue LBM A 301 source : AC1 11) chain A residue 144 type sequence W description binding site for residue LBM A 301 source : AC1 12) chain A residue 145 type sequence G description binding site for residue LBM A 301 source : AC1 13) chain A residue 148 type sequence V description binding site for residue LBM A 301 source : AC1 14) chain A residue 149 type sequence A description binding site for residue LBM A 301 source : AC1 15) chain A residue 152 type sequence E description binding site for residue LBM A 301 source : AC1 16) chain A residue 153 type sequence F description binding site for residue LBM A 301 source : AC1 17) chain A residue 198 type sequence F description binding site for residue LBM A 301 source : AC1 18) chain A residue 202 type sequence Y description binding site for residue LBM A 301 source : AC1 19) chain A residue 12 type sequence R description binding site for residue 2PE A 302 source : AC2 20) chain A residue 108 type sequence Y description binding site for residue 2PE A 302 source : AC2 21) chain A residue 172 type sequence N description binding site for residue 2PE A 302 source : AC2 22) chain A residue 137-155 type prosite sequence LFRDGVNWGRIVAFFEFGG description BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFeFGG source prosite : PS01080 23) chain A residue 188-199 type prosite sequence WIQDNGGWDAFV description BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqdnGGWDaFV source prosite : PS01258 24) chain A residue 93-107 type prosite sequence VHLTLRQAGDDFSRR description BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VhltLRqAGDDFSRR source prosite : PS01259 25) chain A residue 10-30 type prosite sequence DNREIVMKYIHYKLSQRGYEW description BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. DNREIVmKYIHYKLSQRGYeW source prosite : PS01260 26) chain A residue 34 type SITE sequence D description Cleavage; by caspase-3 source Swiss-Prot : SWS_FT_FI1

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