eF-site ID 6nri-A PDB Code 6nri Chain A click to enlarge Title Crystal Structure of human PARP-1 ART domain bound to inhibitor UTT83 Classification transferase/transferase inhibitor Compound Poly [ADP-ribose] polymerase 1 Source (PARP1_HUMAN) Sequence A:  KSKLPKPVQDLIKMIFGGDPIDVNYEKLKTDIKVVDRDSE EAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYK PFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPEAPVTGY MFGKGIYFADMVSKSANYCHTSQGDPIGLILLGEVALGNM YELKHASHISKLPKGKHSVKGLGKTTPDPSANISLDGVDV PLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLLKLKFNF K Description Functional site 1) chain A residue 862 type sequence H description binding site for residue KYM A 1101 source : AC1 2) chain A residue 863 type sequence G description binding site for residue KYM A 1101 source : AC1 3) chain A residue 865 type sequence R description binding site for residue KYM A 1101 source : AC1 4) chain A residue 868 type sequence N description binding site for residue KYM A 1101 source : AC1 5) chain A residue 888 type sequence G description binding site for residue KYM A 1101 source : AC1 6) chain A residue 889 type sequence Y description binding site for residue KYM A 1101 source : AC1 7) chain A residue 896 type sequence Y description binding site for residue KYM A 1101 source : AC1 8) chain A residue 897 type sequence F description binding site for residue KYM A 1101 source : AC1 9) chain A residue 904 type sequence S description binding site for residue KYM A 1101 source : AC1 10) chain A residue 907 type sequence Y description binding site for residue KYM A 1101 source : AC1 11) chain A residue 766 type sequence K description binding site for residue CIT A 1102 source : AC2 12) chain A residue 826 type sequence H description binding site for residue CIT A 1102 source : AC2 13) chain A residue 903 type sequence K description binding site for residue CIT A 1102 source : AC2 14) chain A residue 907 type sequence Y description binding site for residue CIT A 1102 source : AC2 15) chain A residue 984 type sequence L description binding site for residue CIT A 1102 source : AC2 16) chain A residue 985 type sequence L description binding site for residue CIT A 1102 source : AC2 17) chain A residue 986 type sequence Y description binding site for residue CIT A 1102 source : AC2 18) chain A residue 862 type sequence H description binding site for residue DMS A 1103 source : AC3 19) chain A residue 878 type sequence R description binding site for residue DMS A 1103 source : AC3 20) chain A residue 889 type sequence Y description binding site for residue DMS A 1103 source : AC3 21) chain A residue 894 type sequence G description binding site for residue DMS A 1103 source : AC3 22) chain A residue 895 type sequence I description binding site for residue DMS A 1103 source : AC3 23) chain A residue 896 type sequence Y description binding site for residue DMS A 1103 source : AC3 24) chain A residue 988 type ACT_SITE sequence E description For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 862 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 871 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 878 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 904 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2

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