eF-site ID 6npe-B PDB Code 6npe Chain B click to enlarge Title C-abl Kinase domain with the activator(cmpd6), 2-cyano-N-(4-(3,4-dichlorophenyl)thiazol-2-yl)acetamide Classification TRANSFERASE Compound Tyrosine-protein kinase ABL1 Source (ABL1_HUMAN) Sequence B:  DKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKT LVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFM TYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKN FIHRDLAARNCLVGENHLVKVADFGFPIKWTAPESLAYNK FSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKD YRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFET MFQESSISDEVEKELG Description Functional site 1) chain B residue 313 type sequence K description binding site for residue SO4 B 601 source : AC5 2) chain B residue 474 type sequence D description binding site for residue SO4 B 602 source : AC6 3) chain B residue 476 type sequence R description binding site for residue SO4 B 602 source : AC6 4) chain B residue 492 type sequence R description binding site for residue SO4 B 602 source : AC6 5) chain B residue 495 type sequence W description binding site for residue SO4 B 602 source : AC6 6) chain B residue 267 type sequence L description binding site for residue STI B 603 source : AC7 7) chain B residue 290 type sequence K description binding site for residue STI B 603 source : AC7 8) chain B residue 305 type sequence E description binding site for residue STI B 603 source : AC7 9) chain B residue 309 type sequence M description binding site for residue STI B 603 source : AC7 10) chain B residue 312 type sequence I description binding site for residue STI B 603 source : AC7 11) chain B residue 318 type sequence V description binding site for residue STI B 603 source : AC7 12) chain B residue 332 type sequence I description binding site for residue STI B 603 source : AC7 13) chain B residue 334 type sequence T description binding site for residue STI B 603 source : AC7 14) chain B residue 336 type sequence F description binding site for residue STI B 603 source : AC7 15) chain B residue 337 type sequence M description binding site for residue STI B 603 source : AC7 16) chain B residue 379 type sequence I description binding site for residue STI B 603 source : AC7 17) chain B residue 380 type sequence H description binding site for residue STI B 603 source : AC7 18) chain B residue 399 type sequence A description binding site for residue STI B 603 source : AC7 19) chain B residue 400 type sequence D description binding site for residue STI B 603 source : AC7 20) chain B residue 401 type sequence F description binding site for residue STI B 603 source : AC7 21) chain B residue 356 type sequence A description binding site for residue KWD B 604 source : AC8 22) chain B residue 359 type sequence L description binding site for residue KWD B 604 source : AC8 23) chain B residue 363 type sequence A description binding site for residue KWD B 604 source : AC8 24) chain B residue 448 type sequence L description binding site for residue KWD B 604 source : AC8 25) chain B residue 451 type sequence I description binding site for residue KWD B 604 source : AC8 26) chain B residue 452 type sequence A description binding site for residue KWD B 604 source : AC8 27) chain B residue 454 type sequence Y description binding site for residue KWD B 604 source : AC8 28) chain B residue 481 type sequence E description binding site for residue KWD B 604 source : AC8 29) chain B residue 482 type sequence G description binding site for residue KWD B 604 source : AC8 30) chain B residue 484 type sequence P description binding site for residue KWD B 604 source : AC8 31) chain B residue 512 type sequence F description binding site for residue KWD B 604 source : AC8 32) chain B residue 357 type sequence V description binding site for residue 2PE B 605 source : AC9 33) chain B residue 361 type sequence Y description binding site for residue 2PE B 605 source : AC9 34) chain B residue 432 type sequence Y description binding site for residue 2PE B 605 source : AC9 35) chain B residue 434 type sequence K description binding site for residue 2PE B 605 source : AC9 36) chain B residue 516 type sequence F description binding site for residue 2PE B 605 source : AC9 37) chain B residue 382 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 38) chain B residue 267 type BINDING sequence L description source Swiss-Prot : SWS_FT_FI2 39) chain B residue 290 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI2 40) chain B residue 335 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI2 41) chain B residue 272 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 42) chain B residue 276 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 43) chain B residue 432 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI4 44) chain B residue 465 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P00520 source Swiss-Prot : SWS_FT_FI6

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