eF-site ID 6npe-A
PDB Code 6npe
Chain A

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Title C-abl Kinase domain with the activator(cmpd6), 2-cyano-N-(4-(3,4-dichlorophenyl)thiazol-2-yl)acetamide
Classification TRANSFERASE
Compound Tyrosine-protein kinase ABL1
Source (ABL1_HUMAN)
Sequence A:  YDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVK
TLKVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITE
FMTYGNLLDYLRECNRQEVNAVVLLYMATQISSAMEYLEK
KNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAH
AGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYG
MSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMRACW
QWNPSDRPSFAEIHQAFETMFQES
Description


Functional site

1) chain A
residue 326
type
sequence R
description binding site for residue SO4 A 601
source : AC1

2) chain A
residue 479
type
sequence R
description binding site for residue SO4 A 601
source : AC1

3) chain A
residue 482
type
sequence G
description binding site for residue SO4 A 601
source : AC1

4) chain A
residue 281
type
sequence K
description binding site for residue SO4 A 602
source : AC2

5) chain A
residue 492
type
sequence R
description binding site for residue SO4 A 602
source : AC2

6) chain A
residue 496
type
sequence Q
description binding site for residue SO4 A 602
source : AC2

7) chain A
residue 267
type
sequence L
description binding site for residue STI A 603
source : AC3

8) chain A
residue 288
type
sequence A
description binding site for residue STI A 603
source : AC3

9) chain A
residue 290
type
sequence K
description binding site for residue STI A 603
source : AC3

10) chain A
residue 305
type
sequence E
description binding site for residue STI A 603
source : AC3

11) chain A
residue 309
type
sequence M
description binding site for residue STI A 603
source : AC3

12) chain A
residue 312
type
sequence I
description binding site for residue STI A 603
source : AC3

13) chain A
residue 318
type
sequence V
description binding site for residue STI A 603
source : AC3

14) chain A
residue 332
type
sequence I
description binding site for residue STI A 603
source : AC3

15) chain A
residue 334
type
sequence T
description binding site for residue STI A 603
source : AC3

16) chain A
residue 336
type
sequence F
description binding site for residue STI A 603
source : AC3

17) chain A
residue 337
type
sequence M
description binding site for residue STI A 603
source : AC3

18) chain A
residue 379
type
sequence I
description binding site for residue STI A 603
source : AC3

19) chain A
residue 380
type
sequence H
description binding site for residue STI A 603
source : AC3

20) chain A
residue 399
type
sequence A
description binding site for residue STI A 603
source : AC3

21) chain A
residue 400
type
sequence D
description binding site for residue STI A 603
source : AC3

22) chain A
residue 401
type
sequence F
description binding site for residue STI A 603
source : AC3

23) chain A
residue 351
type
sequence R
description binding site for residue KWD A 604
source : AC4

24) chain A
residue 356
type
sequence A
description binding site for residue KWD A 604
source : AC4

25) chain A
residue 359
type
sequence L
description binding site for residue KWD A 604
source : AC4

26) chain A
residue 363
type
sequence A
description binding site for residue KWD A 604
source : AC4

27) chain A
residue 448
type
sequence L
description binding site for residue KWD A 604
source : AC4

28) chain A
residue 451
type
sequence I
description binding site for residue KWD A 604
source : AC4

29) chain A
residue 452
type
sequence A
description binding site for residue KWD A 604
source : AC4

30) chain A
residue 454
type
sequence Y
description binding site for residue KWD A 604
source : AC4

31) chain A
residue 481
type
sequence E
description binding site for residue KWD A 604
source : AC4

32) chain A
residue 482
type
sequence G
description binding site for residue KWD A 604
source : AC4

33) chain A
residue 484
type
sequence P
description binding site for residue KWD A 604
source : AC4

34) chain A
residue 512
type
sequence F
description binding site for residue KWD A 604
source : AC4

35) chain A
residue 473
type
sequence K
description binding site for residue SO4 B 601
source : AC5

36) chain A
residue 267-290
type prosite
sequence LGGGQYGEVYEGVWKKYSLTVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGGGQYGEVYeGvwkkyslt..........VAVK
source prosite : PS00107

37) chain A
residue 378-390
type prosite
sequence FIHRDLAARNCLV
description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FIHrDLAARNCLV
source prosite : PS00109

38) chain A
residue 382
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

39) chain A
residue 267
type BINDING
sequence L
description
source Swiss-Prot : SWS_FT_FI2

40) chain A
residue 290
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI2

41) chain A
residue 335
type BINDING
sequence E
description
source Swiss-Prot : SWS_FT_FI2

42) chain A
residue 272
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI4

43) chain A
residue 276
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI4

44) chain A
residue 432
type MOD_RES
sequence Y
description Phosphotyrosine => ECO:0007744|PubMed:23186163
source Swiss-Prot : SWS_FT_FI4

45) chain A
residue 412
type MOD_RES
sequence Y
description Phosphotyrosine; by autocatalysis and SRC-type Tyr-kinases => ECO:0000269|PubMed:16912036
source Swiss-Prot : SWS_FT_FI5

46) chain A
residue 465
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P00520
source Swiss-Prot : SWS_FT_FI6


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