eF-site ID 6nn8-E PDB Code 6nn8 Chain E click to enlarge Title The structure of human liver pyruvate kinase, hLPYK-S531E Classification TRANSFERASE Compound Pyruvate kinase PKLR Source (KPYR_HUMAN) Sequence E:  AFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIAT IGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIAN VREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQVELVK GSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYI DDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLPGAQV DLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRA ALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGD LGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLESMIT KPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVK MQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGA VEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIAVTRS AQAARQVHLCRGVFPLLYREPPWADDVDRRVQFGIESGKL RGFLRVGDLVIVVTGWRPYTNIMRVLSIS Description Functional site 1) chain E residue 333 type sequence G description binding site for residue EDO E 601 source : AF1 2) chain E residue 334 type sequence K description binding site for residue EDO E 601 source : AF1 3) chain E residue 335 type sequence P description binding site for residue EDO E 601 source : AF1 4) chain E residue 369 type sequence D description binding site for residue EDO E 601 source : AF1 5) chain E residue 451 type sequence Q description binding site for residue EDO E 601 source : AF1 6) chain E residue 454 type sequence S description binding site for residue EDO E 601 source : AF1 7) chain E residue 455 type sequence R description binding site for residue EDO E 601 source : AF1 8) chain E residue 457 type sequence R description binding site for residue EDO E 601 source : AF1 9) chain E residue 478 type sequence C description binding site for residue EDO E 601 source : AF1 10) chain E residue 222 type sequence N description binding site for residue EDO E 602 source : AF2 11) chain E residue 223 type sequence L description binding site for residue EDO E 602 source : AF2 12) chain E residue 226 type sequence A description binding site for residue EDO E 602 source : AF2 13) chain E residue 256 type sequence F description binding site for residue EDO E 602 source : AF2 14) chain E residue 285 type sequence N description binding site for residue EDO E 602 source : AF2 15) chain E residue 312 type sequence E description binding site for residue EDO E 602 source : AF2 16) chain E residue 56 type sequence S description binding site for residue EDO E 603 source : AF3 17) chain E residue 58 type sequence S description binding site for residue EDO E 603 source : AF3 18) chain E residue 82 type sequence N description binding site for residue EDO E 603 source : AF3 19) chain E residue 476 type sequence H description binding site for residue EDO E 603 source : AF3 20) chain E residue 481 type sequence V description binding site for residue EDO E 603 source : AF3 21) chain E residue 482 type sequence F description binding site for residue EDO E 603 source : AF3 22) chain E residue 85 type sequence R description binding site for residue EDO E 604 source : AF4 23) chain E residue 282 type sequence K description binding site for residue EDO E 604 source : AF4 24) chain E residue 303 type sequence M description binding site for residue EDO E 604 source : AF4 25) chain E residue 305 type sequence A description binding site for residue EDO E 604 source : AF4 26) chain E residue 307 type sequence G description binding site for residue EDO E 604 source : AF4 27) chain E residue 308 type sequence D description binding site for residue EDO E 604 source : AF4 28) chain E residue 340 type sequence T description binding site for residue EDO E 604 source : AF4 29) chain E residue 278 type sequence K description binding site for residue EDO E 605 source : AF5 30) chain E residue 451 type sequence Q description binding site for residue EDO E 605 source : AF5 31) chain E residue 297 type sequence E description binding site for residue EDO E 606 source : AF6 32) chain E residue 299 type sequence S description binding site for residue EDO E 606 source : AF6 33) chain E residue 334 type sequence K description binding site for residue EDO E 606 source : AF6 34) chain E residue 33 type sequence A description binding site for residue EDO E 607 source : AF7 35) chain E residue 403 type sequence H description binding site for residue EDO E 607 source : AF7 36) chain E residue 404 type sequence R description binding site for residue EDO E 607 source : AF7 37) chain E residue 459 type sequence R description binding site for residue EDO E 607 source : AF7 38) chain E residue 89 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 39) chain E residue 85 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 40) chain E residue 87 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 41) chain E residue 125 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 42) chain E residue 126 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 43) chain E residue 282 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 44) chain E residue 284 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 45) chain E residue 307 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 46) chain E residue 308 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 47) chain E residue 340 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 48) chain E residue 444 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 49) chain E residue 494 type BINDING sequence W description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 50) chain E residue 501 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 51) chain E residue 528 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 52) chain E residue 219 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P14618 source Swiss-Prot : SWS_FT_FI3 53) chain E residue 132 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P14618 source Swiss-Prot : SWS_FT_FI3 54) chain E residue 282 type SITE sequence K description Transition state stabilizer => ECO:0000250|UniProtKB:P00549 source Swiss-Prot : SWS_FT_FI4 55) chain E residue 261 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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