eF-site ID 6nn8-B PDB Code 6nn8 Chain B click to enlarge Title The structure of human liver pyruvate kinase, hLPYK-S531E Classification TRANSFERASE Compound Pyruvate kinase PKLR Source (KPYR_HUMAN) Sequence B:  AFFQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIAT IGPASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIAN VREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGESEV ELVKGSQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGG RIYIDDGLISLVVQKIGPEGLVTQVENGGVLGSRKGVNLP GAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVA AVRAALGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMV ARGDLGIEIPAEKVFLAQKMMIGRCNLAGKPVVCATQMLE SMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPV EAVKMQHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVT AIGAVEAAFKCCAAAIIVLTTTGRSAQLLSRYRPRAAVIA VTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQF GIESGKLRGFLRVGDLVIVVTGWRPGEGYTNIMRVLSI Description Functional site 1) chain B residue 278 type sequence K description binding site for residue EDO B 601 source : AD2 2) chain B residue 451 type sequence Q description binding site for residue EDO B 601 source : AD2 3) chain B residue 24 type sequence F description binding site for residue EDO B 602 source : AD3 4) chain B residue 28 type sequence Q description binding site for residue EDO B 602 source : AD3 5) chain B residue 436 type sequence C description binding site for residue EDO B 602 source : AD3 6) chain B residue 437 type sequence A description binding site for residue EDO B 602 source : AD3 7) chain B residue 85 type sequence R description binding site for residue EDO B 603 source : AD4 8) chain B residue 282 type sequence K description binding site for residue EDO B 603 source : AD4 9) chain B residue 284 type sequence E description binding site for residue EDO B 603 source : AD4 10) chain B residue 305 type sequence A description binding site for residue EDO B 603 source : AD4 11) chain B residue 307 type sequence G description binding site for residue EDO B 603 source : AD4 12) chain B residue 340 type sequence T description binding site for residue EDO B 603 source : AD4 13) chain B residue 28 type sequence Q description binding site for residue EDO B 604 source : AD5 14) chain B residue 51 type sequence P description binding site for residue EDO B 604 source : AD5 15) chain B residue 53 type sequence A description binding site for residue EDO B 604 source : AD5 16) chain B residue 395 type sequence R description binding site for residue EDO B 604 source : AD5 17) chain B residue 399 type sequence A description binding site for residue EDO B 604 source : AD5 18) chain B residue 443 type sequence L description binding site for residue EDO B 605 source : AD6 19) chain B residue 444 type sequence T description binding site for residue EDO B 605 source : AD6 20) chain B residue 445 type sequence T description binding site for residue EDO B 605 source : AD6 21) chain B residue 465 type sequence V description binding site for residue EDO B 605 source : AD6 22) chain B residue 466 type sequence T description binding site for residue EDO B 605 source : AD6 23) chain B residue 467 type sequence R description binding site for residue EDO B 605 source : AD6 24) chain B residue 501 type sequence R description binding site for residue EDO B 605 source : AD6 25) chain B residue 289 type sequence V description binding site for residue EDO B 606 source : AD7 26) chain B residue 290 type sequence K description binding site for residue EDO B 606 source : AD7 27) chain B residue 324 type sequence M description binding site for residue EDO B 606 source : AD7 28) chain B residue 328 type sequence R description binding site for residue EDO B 606 source : AD7 29) chain B residue 132 type sequence R description binding site for residue EDO B 607 source : AD8 30) chain B residue 220 type sequence G description binding site for residue EDO B 607 source : AD8 31) chain B residue 85 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 32) chain B residue 89 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 33) chain B residue 87 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 34) chain B residue 125 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 35) chain B residue 126 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 36) chain B residue 282 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 37) chain B residue 284 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 38) chain B residue 307 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 39) chain B residue 308 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 40) chain B residue 340 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 41) chain B residue 444 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 42) chain B residue 494 type BINDING sequence W description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 43) chain B residue 501 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 44) chain B residue 528 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 45) chain B residue 132 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:P14618 source Swiss-Prot : SWS_FT_FI3 46) chain B residue 219 type BINDING sequence K description BINDING => ECO:0000250|UniProtKB:P14618 source Swiss-Prot : SWS_FT_FI3 47) chain B residue 282 type SITE sequence K description Transition state stabilizer => ECO:0000250|UniProtKB:P00549 source Swiss-Prot : SWS_FT_FI4 48) chain B residue 261 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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