eF-site ID 6nn7-F PDB Code 6nn7 Chain F click to enlarge Title The structure of human liver pyruvate kinase, hLPYK-GGG Classification TRANSFERASE Compound Pyruvate kinase PKLR Source (KPYR_HUMAN) Sequence F:  FQQQQLPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIG PASRSVERLKEMIKAGMNIARLNFSHGSHEYHAESIANVR EAVESFASYRPVAIALDTKGPEILSEQDVRDLRFGVEHGV DIVFASFVRKASDVAAVRAALGPEGHGIKIISKIENHEGV KRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGAD CIMLSGETAKGNFPVEAVKMQHAIAREAEAAVYHRQLFEE LRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRS AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREP PEAIWADDVDRRVQFGIESGKLRGFLRVGDLVIVVTTNIM RVLSIS Description Functional site 1) chain F residue 71 type sequence E description binding site for residue EDO C 607 source : AD6 2) chain F residue 333 type sequence G description binding site for residue EDO F 601 source : AE8 3) chain F residue 334 type sequence K description binding site for residue EDO F 601 source : AE8 4) chain F residue 335 type sequence P description binding site for residue EDO F 601 source : AE8 5) chain F residue 369 type sequence D description binding site for residue EDO F 601 source : AE8 6) chain F residue 454 type sequence S description binding site for residue EDO F 601 source : AE8 7) chain F residue 455 type sequence R description binding site for residue EDO F 601 source : AE8 8) chain F residue 457 type sequence R description binding site for residue EDO F 601 source : AE8 9) chain F residue 478 type sequence C description binding site for residue EDO F 601 source : AE8 10) chain F residue 85 type sequence R description binding site for residue GOL F 602 source : AE9 11) chain F residue 282 type sequence K description binding site for residue GOL F 602 source : AE9 12) chain F residue 305 type sequence A description binding site for residue GOL F 602 source : AE9 13) chain F residue 307 type sequence G description binding site for residue GOL F 602 source : AE9 14) chain F residue 308 type sequence D description binding site for residue GOL F 602 source : AE9 15) chain F residue 340 type sequence T description binding site for residue GOL F 602 source : AE9 16) chain F residue 444 type sequence T description binding site for residue GOL F 603 source : AF1 17) chain F residue 445 type sequence T description binding site for residue GOL F 603 source : AF1 18) chain F residue 446 type sequence T description binding site for residue GOL F 603 source : AF1 19) chain F residue 448 type sequence R description binding site for residue GOL F 603 source : AF1 20) chain F residue 534 type sequence T description binding site for residue GOL F 603 source : AF1 21) chain F residue 85 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 22) chain F residue 89 type BINDING sequence S description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGB source Swiss-Prot : SWS_FT_FI1 23) chain F residue 87 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 24) chain F residue 125 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 25) chain F residue 126 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 26) chain F residue 282 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 27) chain F residue 284 type BINDING sequence E description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 28) chain F residue 307 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 29) chain F residue 308 type BINDING sequence D description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 30) chain F residue 340 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 31) chain F residue 444 type BINDING sequence T description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 32) chain F residue 494 type BINDING sequence W description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 33) chain F residue 501 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11960989, ECO:0007744|PDB:2VGF source Swiss-Prot : SWS_FT_FI2 34) chain F residue 282 type SITE sequence K description Transition state stabilizer => ECO:0000250|UniProtKB:P00549 source Swiss-Prot : SWS_FT_FI4 35) chain F residue 261 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI5

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